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The map label for this gene is polX [H]

Identifier: 226223831

GI number: 226223831

Start: 1236035

End: 1237747

Strand: Direct

Name: polX [H]

Synonym: Lm4b_01236

Alternate gene names: 226223831

Gene position: 1236035-1237747 (Clockwise)

Preceding gene: 226223830

Following gene: 226223832

Centisome position: 42.44

GC content: 39.4

Gene sequence:

>1713_bases
ATGGCTACTAATAAAAAAGAAATTATTCGTTTACTCGGAGAAATTGCCACTTATATGGAATTAAAAGGAGAAAATAGCTT
TAAAATATCTGCTTTCCGCAAAGCTGCACAAGCAATTGAATTAGATAGTAGAAGTTTATCTGAAATTGATGATTTTACGA
AGATTAGTGGCATCGGAAAAACAACGGGCGAAATTATCCAACGTTATTTAGATAGCGGAGAATGTCCAGAACTTGAGGCG
CTTAAAAAAGAAGTACCAGCTGGTCTCGTTCCACTTTTAGATGTGCCAGGGCTAGGAGGCAAGAAATTATCGCGTCTTTA
TCATGAGCTTGGTGTGGTGGATAAAGATACATTACTCCAAGAAGCAGAAAATGGCCATATCGAAGCATTGAAAGGTTTTG
GTAAAAAGTCTGCTGAAAAAATGGCCGAAGCAGTGCGCGAAATGGGTGAGCGCCCTGATAGATATCCGCTAAATGATGTT
TTACCAATCATTCAAAAAGTAGAAGCTTATCTTGCGGATATTGCTCCAATCGAAACTTTTGCTAAAGCTGGAAGTCTACG
CAGATTGCGGGAAACGGTGAAAGATTTAGATTATGTTATTGCGACGGAAAAACCAGAAGAAGTTCAAAAAGCATTACTGG
CATTTCCATTAATTACGGACGTTATTGGAGCTGGTGAAACAAAAGTATCAGCAGTATTAGAAGATAATATTACCATTTCC
GTGGATTTCCGTTTAGTAGAAAAGAAAGCTTTTGCAACGACACTACATCATTTTACGGGTTCTAAAGATCACAACATCAA
AATGCGCCAATTAGCTAAACAATCCAATGAAAAAATAAGTGAGTATGGAGTCGAGCAAGAAGATGGAAGTGTTCGTCACT
TTGAATCGGAAAAAGCATTTTTCGAGCATTTTAAGATTCCGTTTCTCCCACCTGAAGTTCGCCGAGATGGTACAGAAATT
GAGCGCGTGACGAAAGATACAAAATTCCTTGAGTTAAGCGATATTCGCGGGGACTTGCACATGCATACAACTTGGTCGGA
CGGAGCCTACGCGATTCCAGAAATGATTGAAGCATGTATCGCAAAAGGATATGAATACATGGTTATTACAGATCACGGGA
AATTTTTGCGAGTAGCTAATGGTCTGGACGAAAAAAGATTATTGGAGCAGCAAGCAGAAATTAAAAAAATAGCAGCTAAT
TATCCGGAAATTGATGTTTATTCCGGCGTTGAAATGGATATTCTGGCAGATGGGTCGCTTGATTTTGATGATGAGACTTT
GAAGCAGTTGGATTTTGTTATCGCATCCATCCATTCCAGTTTCCAACAATCAGAAGAAGAAATTATGAAGCGATTAAAAA
CGGCCTGTGAAAATCCATATGTGCGTCTGATTGCGCATCCGACAGGTAGAATTGTCGTGAAAAGAAAGCCATATCATGTT
AATATGAAAGAACTAATCCAGTTAGCGAAAAATACAGGAACTGCCCTAGAATTAAATGCCAATCCGCAACGTCTTGATTT
AAACCGTGAGCATTTAGAAATGGCACACGCTGCCGGGGTACCGATTGCGATTAACACAGATGCGCACGACACGAAGCACC
TTGATTTCATGTCTATTGGCGTTCGAGCTGCTACAAAAGCCTGGCTCGACAAATCGGCCATTCTAAATACGAAAACAGCA
GCTGAATTTAAACATTTTTTACAGAATAAATAA

Upstream 100 bases:

>100_bases
CCAAAATAAAAGAAACATTCGATACCAGATGTATACTCTTAGCCAATTTTGGATAGGATTTCTCTGGTATTTTTTAATGA
TTTTACAGGGAGGAATAAAG

Downstream 100 bases:

>100_bases
CTTTTAAAAAGAAGGATGACTAATGGAAAAAAAAGTAGAAGCCATTTTAGAATTTGATAAAATAAAAAAACAACTCACCG
AATTTGCTTCTTCGTCACTG

Product: hypothetical protein

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MATNKKEIIRLLGEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGKTTGEIIQRYLDSGECPELEA
LKKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQEAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDV
LPIIQKVEAYLADIAPIETFAKAGSLRRLRETVKDLDYVIATEKPEEVQKALLAFPLITDVIGAGETKVSAVLEDNITIS
VDFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGSVRHFESEKAFFEHFKIPFLPPEVRRDGTEI
ERVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACIAKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAAN
YPEIDVYSGVEMDILADGSLDFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHV
NMKELIQLAKNTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIGVRAATKAWLDKSAILNTKTA
AEFKHFLQNK

Sequences:

>Translated_570_residues
MATNKKEIIRLLGEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGKTTGEIIQRYLDSGECPELEA
LKKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQEAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDV
LPIIQKVEAYLADIAPIETFAKAGSLRRLRETVKDLDYVIATEKPEEVQKALLAFPLITDVIGAGETKVSAVLEDNITIS
VDFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGSVRHFESEKAFFEHFKIPFLPPEVRRDGTEI
ERVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACIAKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAAN
YPEIDVYSGVEMDILADGSLDFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHV
NMKELIQLAKNTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIGVRAATKAWLDKSAILNTKTA
AEFKHFLQNK
>Mature_569_residues
ATNKKEIIRLLGEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGKTTGEIIQRYLDSGECPELEAL
KKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQEAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDVL
PIIQKVEAYLADIAPIETFAKAGSLRRLRETVKDLDYVIATEKPEEVQKALLAFPLITDVIGAGETKVSAVLEDNITISV
DFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGSVRHFESEKAFFEHFKIPFLPPEVRRDGTEIE
RVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACIAKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAANY
PEIDVYSGVEMDILADGSLDFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHVN
MKELIQLAKNTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIGVRAATKAWLDKSAILNTKTAA
EFKHFLQNK

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1796

COG function: function code L; DNA polymerase IV (family X)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI4505931, Length=335, Percent_Identity=24.7761194029851, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 63983; Mature: 63852

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNKKEIIRLLGEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGK
CCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
TTGEIIQRYLDSGECPELEALKKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQ
CHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
EAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDVLPIIQKVEAYLADIAPIETF
HHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAGSLRRLRETVKDLDYVIATEKPEEVQKALLAFPLITDVIGAGETKVSAVLEDNITIS
HHCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCEEEE
VDFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGSVRHFESEKAF
EEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
FEHFKIPFLPPEVRRDGTEIERVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACI
HHHCCCCCCCHHHHCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHH
AKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAANYPEIDVYSGVEMDILADGSL
HCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCC
DFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
NMKELIQLAKNTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIG
CHHHHHHHHHCCCCEEEECCCCCEECCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
VRAATKAWLDKSAILNTKTAAEFKHFLQNK
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ATNKKEIIRLLGEIATYMELKGENSFKISAFRKAAQAIELDSRSLSEIDDFTKISGIGK
CCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
TTGEIIQRYLDSGECPELEALKKEVPAGLVPLLDVPGLGGKKLSRLYHELGVVDKDTLLQ
CHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHH
EAENGHIEALKGFGKKSAEKMAEAVREMGERPDRYPLNDVLPIIQKVEAYLADIAPIETF
HHCCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AKAGSLRRLRETVKDLDYVIATEKPEEVQKALLAFPLITDVIGAGETKVSAVLEDNITIS
HHCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHEEEECCEEEE
VDFRLVEKKAFATTLHHFTGSKDHNIKMRQLAKQSNEKISEYGVEQEDGSVRHFESEKAF
EEEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
FEHFKIPFLPPEVRRDGTEIERVTKDTKFLELSDIRGDLHMHTTWSDGAYAIPEMIEACI
HHHCCCCCCCHHHHCCCHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHH
AKGYEYMVITDHGKFLRVANGLDEKRLLEQQAEIKKIAANYPEIDVYSGVEMDILADGSL
HCCCEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCC
DFDDETLKQLDFVIASIHSSFQQSEEEIMKRLKTACENPYVRLIAHPTGRIVVKRKPYHV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEECCCCCC
NMKELIQLAKNTGTALELNANPQRLDLNREHLEMAHAAGVPIAINTDAHDTKHLDFMSIG
CHHHHHHHHHCCCCEEEECCCCCEECCCHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHH
VRAATKAWLDKSAILNTKTAAEFKHFLQNK
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]