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The map label for this gene is rsbU

Identifier: 226223511

GI number: 226223511

Start: 929093

End: 930097

Strand: Direct

Name: rsbU

Synonym: Lm4b_00910

Alternate gene names: 226223511

Gene position: 929093-930097 (Clockwise)

Preceding gene: 226223510

Following gene: 226223512

Centisome position: 31.9

GC content: 36.32

Gene sequence:

>1005_bases
ATGGAAAAAGCTTTTGAGGGAAAATACCGTGATATTCTTATTCAGTATTTAGAACATCAAGATGAAGAAATTCTTTATAC
TTGCGAAAAATTATCCAGAGAAGCTATGGAAGAGCGAGTATCACCAGAAGAAATTGTCCATTTACATCGCTCGGTTCTTG
AACTATACGGAAAAGAGTTGCCGGATTTTGTACGATTATCATTTGATGTACTACTAGAAATAATGGTAGGCTACGGCTTA
GCTTATATGGAGCATCTTAGTCTAAGAACCGAGCAAAAAGAATTACGTAGTGAAATCGCTCAAGCAGAAGATATGCAAAA
AACGTTAATGAAAACAGAGGTACCGGAACACGATGAACTTGATTTTGGAGTTATTAGCGTCGCAGCTAGACAAATGAGCG
GTGACTACTATAGCTTTACAGAAGAAGGTGACAAACAAATTGGTATCGCGCTTGCTGATGTTATTGGTAAAGGAATTCCA
GCCGCATTTAGTATTTCCATGATAAAATACGCACTAGCTGGAATGACTGGGGACGACAGAAAACCATCTATCGTACTCGA
ATCATTAAACCAAGTAGCAGAAGAAAATATTAACGACAATATGTTTATCACGATGTTTTACGGGCTTTATCACGAAGATA
CACATTTGTTTGAATATGGTTCAGCCGGACATGAACTGGGCTTATATTACCAACATAAAGAAAACAGCTTTTCTGATTTA
TACGCCAAAGGTTTACCACTGGGTGTAGATAAAAATGCTGTCTACCGTCAATTTGATAAGAAAATTGAAGTGGGGGACGC
TATATTTATTATGTCAGATGGTGTAACAGAAACAAGAACAGCCAATGGTTTTCTTGAACGTGAAGAGTTAACAGAAATTA
TAGCAGCGCATATTTCATTATCTGCTGAAAAAATGGTTCATGCGATTTATGATCAATTAGTTAAAATGCAAAACTTTGAG
TTGCATGATGACTTTACGCTTATTTGTATTAAGCGAACTAAATAA

Upstream 100 bases:

>100_bases
TTAATGGACAGTTTTGATATTGAATCCAGTATTGAAGGCGATTCTAAAGGAACGGTAATTACAACAACGAAATGGGTTCG
GTAAGGAGAGCTAGAAAAAA

Downstream 100 bases:

>100_bases
GAAGAAGTGAAGACGTACCTCATTCTTTAGAGAGCATTTACTGGTGAGTAAACGTATTTAAAGAGTGGAGCGTTTTTATT
TTTGAATGTTTTAATTTTAT

Product: serine phosphatase RsbU

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MEKAFEGKYRDILIQYLEHQDEEILYTCEKLSREAMEERVSPEEIVHLHRSVLELYGKELPDFVRLSFDVLLEIMVGYGL
AYMEHLSLRTEQKELRSEIAQAEDMQKTLMKTEVPEHDELDFGVISVAARQMSGDYYSFTEEGDKQIGIALADVIGKGIP
AAFSISMIKYALAGMTGDDRKPSIVLESLNQVAEENINDNMFITMFYGLYHEDTHLFEYGSAGHELGLYYQHKENSFSDL
YAKGLPLGVDKNAVYRQFDKKIEVGDAIFIMSDGVTETRTANGFLEREELTEIIAAHISLSAEKMVHAIYDQLVKMQNFE
LHDDFTLICIKRTK

Sequences:

>Translated_334_residues
MEKAFEGKYRDILIQYLEHQDEEILYTCEKLSREAMEERVSPEEIVHLHRSVLELYGKELPDFVRLSFDVLLEIMVGYGL
AYMEHLSLRTEQKELRSEIAQAEDMQKTLMKTEVPEHDELDFGVISVAARQMSGDYYSFTEEGDKQIGIALADVIGKGIP
AAFSISMIKYALAGMTGDDRKPSIVLESLNQVAEENINDNMFITMFYGLYHEDTHLFEYGSAGHELGLYYQHKENSFSDL
YAKGLPLGVDKNAVYRQFDKKIEVGDAIFIMSDGVTETRTANGFLEREELTEIIAAHISLSAEKMVHAIYDQLVKMQNFE
LHDDFTLICIKRTK
>Mature_334_residues
MEKAFEGKYRDILIQYLEHQDEEILYTCEKLSREAMEERVSPEEIVHLHRSVLELYGKELPDFVRLSFDVLLEIMVGYGL
AYMEHLSLRTEQKELRSEIAQAEDMQKTLMKTEVPEHDELDFGVISVAARQMSGDYYSFTEEGDKQIGIALADVIGKGIP
AAFSISMIKYALAGMTGDDRKPSIVLESLNQVAEENINDNMFITMFYGLYHEDTHLFEYGSAGHELGLYYQHKENSFSDL
YAKGLPLGVDKNAVYRQFDKKIEVGDAIFIMSDGVTETRTANGFLEREELTEIIAAHISLSAEKMVHAIYDQLVKMQNFE
LHDDFTLICIKRTK

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 38247; Mature: 38247

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKAFEGKYRDILIQYLEHQDEEILYTCEKLSREAMEERVSPEEIVHLHRSVLELYGKEL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PDFVRLSFDVLLEIMVGYGLAYMEHLSLRTEQKELRSEIAQAEDMQKTLMKTEVPEHDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFGVISVAARQMSGDYYSFTEEGDKQIGIALADVIGKGIPAAFSISMIKYALAGMTGDDR
CHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPSIVLESLNQVAEENINDNMFITMFYGLYHEDTHLFEYGSAGHELGLYYQHKENSFSDL
CHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCHHEECCCCCCEECEEEEECCCCHHHH
YAKGLPLGVDKNAVYRQFDKKIEVGDAIFIMSDGVTETRTANGFLEREELTEIIAAHISL
HHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHH
SAEKMVHAIYDQLVKMQNFELHDDFTLICIKRTK
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MEKAFEGKYRDILIQYLEHQDEEILYTCEKLSREAMEERVSPEEIVHLHRSVLELYGKEL
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
PDFVRLSFDVLLEIMVGYGLAYMEHLSLRTEQKELRSEIAQAEDMQKTLMKTEVPEHDEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DFGVISVAARQMSGDYYSFTEEGDKQIGIALADVIGKGIPAAFSISMIKYALAGMTGDDR
CHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
KPSIVLESLNQVAEENINDNMFITMFYGLYHEDTHLFEYGSAGHELGLYYQHKENSFSDL
CHHHHHHHHHHHHHCCCCCCEEEEEEEHHHCCCCHHEECCCCCCEECEEEEECCCCHHHH
YAKGLPLGVDKNAVYRQFDKKIEVGDAIFIMSDGVTETRTANGFLEREELTEIIAAHISL
HHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHCCCCHHHHHHHHHHHHHHHH
SAEKMVHAIYDQLVKMQNFELHDDFTLICIKRTK
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]