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The map label for this gene is hemY [H]

Identifier: 226223503

GI number: 226223503

Start: 923517

End: 924896

Strand: Direct

Name: hemY [H]

Synonym: Lm4b_00902

Alternate gene names: 226223503

Gene position: 923517-924896 (Clockwise)

Preceding gene: 226223502

Following gene: 226223504

Centisome position: 31.71

GC content: 41.52

Gene sequence:

>1380_bases
GTGAAACATATAGTCATTATCGGAGGCGGCTTATCAGGGCTTGCAGCAGCGTATGAACTACAAAAAACACATCCGAATTA
TACGTGGGAATTAGTAGAAAAAGACAAAAAACTAGGCGGGAAATTTGAAACGGTTAAACGGGACGGATTTTTAATTGAAA
AAGGACCAGACTCCTTTTTAGCAAGAAAACCAGCTGGTGTAGGCTTAGTGAAGGATTTAGGACTCGAAGATAAACTGATT
GCGAACGCGACAGGAAGATCCTACATTTACCACCAAAAAGCACTTCATCCGATTCCAGAAGGCTCAGTGATGGGAATTCC
AACAGATAAAGAAGCATTGCTAGCTAGTACACTCGTATCCGAAATTGGGAAAGCTCGCGCACTTCAAGAACCAACAATGG
AACGAAATAATCAAGAACAAGATCAAGCACTTGGCGAATTCTTTGAAGCGCGATTCGGTAAAGAATTAGTCAAAACAATT
ATCGAACCACTTTTATCAGGAATTTATGCCGGAGATATATACAAAATGAGTTTACGCGCCACTTTTCCACAATTCGAACA
AGCAGTTAAAAAATATGGGAATTTGATGGATGGCTTAAAAGAAAGTAGCATGCAAACGACAGGGACAAAAGCTACTATTG
GTGCTTTTCGAACATTAGAAGGCGGGCTAGATGCGTTACCAAAAGCCATTGCCGCCGCACTTCCAAAAGAAAATTTGCAT
ACAGCAAAACAAGCAACGAACATTACGAAAAAGAATAGCTCTTACGAAATTTCTTTTGTAGATGGCGATAAAATGGAGGC
AGATGGCGTCATTATCGCTGCCACACATGATGCGCTAATTCATTTATTAGCAGAAAAAACGACAGAACCATTCGCGGGAC
AACCGCTTACGACTCTCGCAACTGTCTCATTAGCATACAATGAACAAGATGTACCGATTTTACCAGATGGAACAGGCTAT
CTAGTTGCCAGAACCGCTCCATATAAAACCACTGCTTGTACATGGGTGCAGAAAAAATGGCCGCATATGGTACCAGAAAA
TAAAATGTTACTACGAGGCTTTGTTGGGAAAGCGGGAGAAACTTGGTTAGAGCAAGCAAGTGATGAAGCAATCGTTTCAG
CTGTTTTGAGAGATTATGCGGAAATGATGGACCTTCACGCCGCGCCACTTTTTTATGAAGTAAGCCGAATGAAATCCGCA
ATGCCTCAATACTTAGTTAATCACCAGGACCGACTAAAACAATTGAAAAAGAACATCAAAGCAGATTACCCAGGGGTTTA
TTTTGCAGGAATGAGCTACGAAGGTGTGGGTATTCCTGATTGCATCGCAGGAGCTCAAACAGCCGCTAAGGAATTAGTAG
ATTACTTGGAAGAGGTGTAA

Upstream 100 bases:

>100_bases
TTTGGAAATGGCTGTTCTTTTATTTTTTGTTCAATTACCCTGAAATCTGGTAAAATAGATAGAATAAACGAAAGAGTAGA
TAGAGAGGATTGGTTAAGTA

Downstream 100 bases:

>100_bases
CATGATTAAAGGAATCGGACTAGATATGATTGATTTAGAACGTGTAAAACAAGTCGTGGAAAAGAATCCACGCTTTATCG
AACGTGTTTTAACAGAAAAA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDKKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLEDKLI
ANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVSEIGKARALQEPTMERNNQEQDQALGEFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQAVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLH
TAKQATNITKKNSSYEISFVDGDKMEADGVIIAATHDALIHLLAEKTTEPFAGQPLTTLATVSLAYNEQDVPILPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGETWLEQASDEAIVSAVLRDYAEMMDLHAAPLFYEVSRMKSA
MPQYLVNHQDRLKQLKKNIKADYPGVYFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV

Sequences:

>Translated_459_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDKKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLEDKLI
ANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVSEIGKARALQEPTMERNNQEQDQALGEFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQAVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLH
TAKQATNITKKNSSYEISFVDGDKMEADGVIIAATHDALIHLLAEKTTEPFAGQPLTTLATVSLAYNEQDVPILPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGETWLEQASDEAIVSAVLRDYAEMMDLHAAPLFYEVSRMKSA
MPQYLVNHQDRLKQLKKNIKADYPGVYFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV
>Mature_459_residues
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDKKLGGKFETVKRDGFLIEKGPDSFLARKPAGVGLVKDLGLEDKLI
ANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVSEIGKARALQEPTMERNNQEQDQALGEFFEARFGKELVKTI
IEPLLSGIYAGDIYKMSLRATFPQFEQAVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLH
TAKQATNITKKNSSYEISFVDGDKMEADGVIIAATHDALIHLLAEKTTEPFAGQPLTTLATVSLAYNEQDVPILPDGTGY
LVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGETWLEQASDEAIVSAVLRDYAEMMDLHAAPLFYEVSRMKSA
MPQYLVNHQDRLKQLKKNIKADYPGVYFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=487, Percent_Identity=25.6673511293634, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4506001, Length=487, Percent_Identity=25.6673511293634, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24649745, Length=453, Percent_Identity=23.6203090507726, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 50289; Mature: 50289

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDKKLGGKFETVKRDGFLIEKGPDSFL
CCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCEEEECCCCHHH
ARKPAGVGLVKDLGLEDKLIANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVS
HCCCCCCCHHHHCCCCCHHEECCCCCCEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHH
EIGKARALQEPTMERNNQEQDQALGEFFEARFGKELVKTIIEPLLSGIYAGDIYKMSLRA
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
TFPQFEQAVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
TAKQATNITKKNSSYEISFVDGDKMEADGVIIAATHDALIHLLAEKTTEPFAGQPLTTLA
HHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHHH
TVSLAYNEQDVPILPDGTGYLVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGE
EEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHH
TWLEQASDEAIVSAVLRDYAEMMDLHAAPLFYEVSRMKSAMPQYLVNHQDRLKQLKKNIK
HHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCC
ADYPGVYFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHIVIIGGGLSGLAAAYELQKTHPNYTWELVEKDKKLGGKFETVKRDGFLIEKGPDSFL
CCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCEEEECCCCHHH
ARKPAGVGLVKDLGLEDKLIANATGRSYIYHQKALHPIPEGSVMGIPTDKEALLASTLVS
HCCCCCCCHHHHCCCCCHHEECCCCCCEEEHHHHCCCCCCCCEECCCCCHHHHHHHHHHH
EIGKARALQEPTMERNNQEQDQALGEFFEARFGKELVKTIIEPLLSGIYAGDIYKMSLRA
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHH
TFPQFEQAVKKYGNLMDGLKESSMQTTGTKATIGAFRTLEGGLDALPKAIAAALPKENLH
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHH
TAKQATNITKKNSSYEISFVDGDKMEADGVIIAATHDALIHLLAEKTTEPFAGQPLTTLA
HHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHCCCCCCCCCHHHHH
TVSLAYNEQDVPILPDGTGYLVARTAPYKTTACTWVQKKWPHMVPENKMLLRGFVGKAGE
EEEEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCHH
TWLEQASDEAIVSAVLRDYAEMMDLHAAPLFYEVSRMKSAMPQYLVNHQDRLKQLKKNIK
HHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCC
ADYPGVYFAGMSYEGVGIPDCIAGAQTAAKELVDYLEEV
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]