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The map label for this gene is mvk [H]

Identifier: 226222649

GI number: 226222649

Start: 12917

End: 13885

Strand: Direct

Name: mvk [H]

Synonym: Lm4b_00010

Alternate gene names: 226222649

Gene position: 12917-13885 (Clockwise)

Preceding gene: 226222648

Following gene: 226222650

Centisome position: 0.44

GC content: 38.08

Gene sequence:

>969_bases
TTGGCTACAGGCATTGGGACAGCTAAAATGATATTATGCGGAGAACATGCAGTTGTATACGGAGAACCGGCAATTTCAGT
CCCATTTACACAAGCAGTTGTAACGACAAATGTAGAAAATTCTACAAAAACCAAATTTTCTTCGGCATTTTTTTCAGGTG
ATTTAGATGATATGCCTGATTTCTTAGCAGGAATCAAAGCATTAGTTGTAGATGTTTTAAATGAGATTGGAAAAGGCGAA
TGCGTTTCTATCCATGTAGTTTCAGGTGTTCCAATTGGACGAGGTTTAGGTTCAAGTGCCGCTGTAGCAACAAGTATTGC
GCGTGGTTTATATAAATATTTTAATCAAGAATTAGACTCGAAAAAATTATTAGCCATTGTGAATGCTGCAGAAAAAATTG
CTCATGGCAATGCTAGTGGTGTTGATGCTATCACGGTTGTGAGTGAAAAACCAGTATGGTATGAGCGAGATCGAAAACTA
GAAATTATGCATTTTTCAAAAAAAATCACGTTCGTAGTAGCAGATACTGGAGTTCCAAGTGAAACCAGAGACGCGGTGAA
GGATGTTCAAGCTTTATATAAAGAAAATCAAACAGAAATTGGTAAAATAATTCATCAACTCGGCGATATTTCCCGGGAAA
TAAAGACTCATTTAGAAGGCGATGCAGATACTGTGAAAATAGGTGCTGCAATGAATAAGGCACAATCTTATTTAGAAACT
TTGACAGTAAGTGATAGTAGTTTAGAGAAATTAATAGAAGTAGCTAGAAGTAGTGGTGCAGACGGGGCAAAACTTACAGG
TGGCGGTAGAGGTGGATGTATTATCGCTGTAGCAAAAAATCAAGAAATCGCTGAACAAATAACGAAGGAGCTTCATAATG
CTGGAGCTGCACAAGAATGGATTTTTACGATTGGAGAAGGTAGTTATGAAAGCGACAGCCATCGCACACACGAATGTGGC
GCTAATTAA

Upstream 100 bases:

>100_bases
GGGTCAAAAAAAGTTCTATAATAAGGTTTTAGTGAAAAAATTATGGTATCATGAAGTATTAAAGTTTGTACTATTTTGAT
GGAGAAAGGATTGGCGTACA

Downstream 100 bases:

>100_bases
ATACTGGGGAAAACGCGATGAACACTTGATTCTACCTGCAAACAGTAGTTTATCCTTCACGGTAGATAAATTTTATACAA
AAACAACGGTAGAATGGGAC

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVENSTKTKFSSAFFSGDLDDMPDFLAGIKALVVDVLNEIGKGE
CVSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDSKKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKL
EIMHFSKKITFVVADTGVPSETRDAVKDVQALYKENQTEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLET
LTVSDSSLEKLIEVARSSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKELHNAGAAQEWIFTIGEGSYESDSHRTHECG
AN

Sequences:

>Translated_322_residues
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVENSTKTKFSSAFFSGDLDDMPDFLAGIKALVVDVLNEIGKGE
CVSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDSKKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKL
EIMHFSKKITFVVADTGVPSETRDAVKDVQALYKENQTEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLET
LTVSDSSLEKLIEVARSSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKELHNAGAAQEWIFTIGEGSYESDSHRTHECG
AN
>Mature_321_residues
ATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVENSTKTKFSSAFFSGDLDDMPDFLAGIKALVVDVLNEIGKGEC
VSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDSKKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKLE
IMHFSKKITFVVADTGVPSETRDAVKDVQALYKENQTEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLETL
TVSDSSLEKLIEVARSSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKELHNAGAAQEWIFTIGEGSYESDSHRTHECGA
N

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34227; Mature: 34096

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVENSTKTKFSSAFFSGDLDDMPD
CCCCCCCEEEEEECCCEEEECCCCCCCCCHHEEEEECCCCCHHHHHHHHHHCCCCCHHHH
FLAGIKALVVDVLNEIGKGECVSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDS
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
KKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKLEIMHFSKKITFVVADTGVPS
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEECCCCEEEEEEECCEEEEEEECCCCCH
ETRDAVKDVQALYKENQTEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
LTVSDSSLEKLIEVARSSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKELHNAGAAQEW
HHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCE
IFTIGEGSYESDSHRTHECGAN
EEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVENSTKTKFSSAFFSGDLDDMPD
CCCCCCEEEEEECCCEEEECCCCCCCCCHHEEEEECCCCCHHHHHHHHHHCCCCCHHHH
FLAGIKALVVDVLNEIGKGECVSIHVVSGVPIGRGLGSSAAVATSIARGLYKYFNQELDS
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
KKLLAIVNAAEKIAHGNASGVDAITVVSEKPVWYERDRKLEIMHFSKKITFVVADTGVPS
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEECCCCEEEEEEECCEEEEEEECCCCCH
ETRDAVKDVQALYKENQTEIGKIIHQLGDISREIKTHLEGDADTVKIGAAMNKAQSYLET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHH
LTVSDSSLEKLIEVARSSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKELHNAGAAQEW
HHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCE
IFTIGEGSYESDSHRTHECGAN
EEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]