BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession	NC_012442
Length	1,185,518

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The map label for this gene is xecD [H]

Identifier: 225685899

GI number: 225685899

Start: 27354

End: 27875

Strand: Direct

Name: xecD [H]

Synonym: BMEA_B0033

Alternate gene names: 225685899

Gene position: 27354-27875 (Clockwise)

Preceding gene: 225685898

Following gene: 225685900

Centisome position: 2.31

GC content: 63.41

Gene sequence:

>522_bases
TTGAGCCGTTTTGGCGGTCTTGACGTATTGGTGAACAATGCCGGTGTTGCCGGTCGCGCCGCCTTCGACCAGCCCGAGGC
GGTCGAGGTCTGGGACCGGGTGATCGGCGTCAACCTTGAAGGCGCGTTCAATGTTTCCCATGCGCTCGTGCCTGCGCTGA
AGGCCGCGAAGGGCAATGTGGTGCATCTGTGCTCGGTCGCGGGTTTCGTGTCCGGCGGCTCCACGGCGGGTTATGTCGTC
TCCAAGGGGGCGATCCGTTCGCTGACGCAGGTGATGGCGCGTGATCTGGCCCCGCATGGCATCCGCGTCAATGCGGTTGC
GCCCGGCATCATGATGAGCGAGGTGGCGGTGGCCCAGCTCAACCGTCCGGGTGGCACAGACTGGTTTATGAACCGTGTGA
TGATGAAGCGCATCGGCGAAACCAGCGAAGTCGTCGATCCCGTCGTTTTTCTCGCGTCCCCGATGGCAAGCTATATCACC
GGCACCATCCTGCCGGTGGATGGCGGCTTCCTGGCCGCGTGA

Upstream 100 bases:

>100_bases
GGCCCAGGCCGATGCGCTGACCGCGAAAGGCTTCGTTGCCGAAGGCCATGCGCTCGATGTCACCGACCGCGACGCAGTTG
CGGCACTGGCTGACGATATA

Downstream 100 bases:

>100_bases
CCTTATCCTGCGCATTTGGCAGCGGCCAAATGCAGTGAAAACAAACAGATAGAGCGGCCCAGCCTTCCTTGAACCGCTCT
GGAGAGCCCTTGCTCCTGGA

Product: cyclopentanol dehydrogenase

Products: NA

Alternate protein names: R-HPCDH; Aliphatic epoxide carboxylation component III [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSRFGGLDVLVNNAGVAGRAAFDQPEAVEVWDRVIGVNLEGAFNVSHALVPALKAAKGNVVHLCSVAGFVSGGSTAGYVV
SKGAIRSLTQVMARDLAPHGIRVNAVAPGIMMSEVAVAQLNRPGGTDWFMNRVMMKRIGETSEVVDPVVFLASPMASYIT
GTILPVDGGFLAA

Sequences:

>Translated_173_residues
MSRFGGLDVLVNNAGVAGRAAFDQPEAVEVWDRVIGVNLEGAFNVSHALVPALKAAKGNVVHLCSVAGFVSGGSTAGYVV
SKGAIRSLTQVMARDLAPHGIRVNAVAPGIMMSEVAVAQLNRPGGTDWFMNRVMMKRIGETSEVVDPVVFLASPMASYIT
GTILPVDGGFLAA
>Mature_172_residues
SRFGGLDVLVNNAGVAGRAAFDQPEAVEVWDRVIGVNLEGAFNVSHALVPALKAAKGNVVHLCSVAGFVSGGSTAGYVVS
KGAIRSLTQVMARDLAPHGIRVNAVAPGIMMSEVAVAQLNRPGGTDWFMNRVMMKRIGETSEVVDPVVFLASPMASYITG
TILPVDGGFLAA

Specific function: Catalyzes the oxidation of 2-(R)-hydroxyalkyl thioesters of CoM to 2-oxoalkyl thioesters of CoM. The enzyme highly specific for the R enantiomers [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=171, Percent_Identity=35.672514619883, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI15277342, Length=143, Percent_Identity=36.3636363636364, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=166, Percent_Identity=34.3373493975904, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI59889578, Length=173, Percent_Identity=32.3699421965318, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI5031737, Length=168, Percent_Identity=31.547619047619, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI19923817, Length=181, Percent_Identity=34.2541436464088, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI66933014, Length=170, Percent_Identity=31.1764705882353, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI126723750, Length=144, Percent_Identity=34.0277777777778, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI10190704, Length=178, Percent_Identity=28.6516853932584, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI4758504, Length=121, Percent_Identity=38.0165289256198, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI33667109, Length=114, Percent_Identity=32.4561403508772, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI40254992, Length=171, Percent_Identity=28.6549707602339, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1790717, Length=171, Percent_Identity=37.4269005847953, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI87082160, Length=179, Percent_Identity=31.8435754189944, Blast_Score=105, Evalue=1e-24,
Organism=Escherichia coli, GI1787335, Length=172, Percent_Identity=34.8837209302326, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789208, Length=175, Percent_Identity=33.7142857142857, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI87082100, Length=177, Percent_Identity=35.0282485875706, Blast_Score=88, Evalue=3e-19,
Organism=Escherichia coli, GI1788459, Length=181, Percent_Identity=33.7016574585635, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI2367175, Length=168, Percent_Identity=36.3095238095238, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787905, Length=170, Percent_Identity=32.3529411764706, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789057, Length=178, Percent_Identity=30.3370786516854, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1786812, Length=173, Percent_Identity=32.3699421965318, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI2367365, Length=177, Percent_Identity=33.8983050847458, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=169, Percent_Identity=27.810650887574, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=173, Percent_Identity=32.3699421965318, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=178, Percent_Identity=33.7078651685393, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=178, Percent_Identity=34.8314606741573, Blast_Score=103, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI115534694, Length=163, Percent_Identity=34.3558282208589, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=181, Percent_Identity=30.939226519337, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=173, Percent_Identity=33.5260115606936, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=165, Percent_Identity=35.1515151515151, Blast_Score=88, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=181, Percent_Identity=30.939226519337, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=184, Percent_Identity=31.5217391304348, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=184, Percent_Identity=32.0652173913043, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=181, Percent_Identity=30.3867403314917, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=181, Percent_Identity=29.8342541436464, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI72000259, Length=185, Percent_Identity=30.2702702702703, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=183, Percent_Identity=29.5081967213115, Blast_Score=73, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=187, Percent_Identity=29.9465240641711, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=188, Percent_Identity=31.3829787234043, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=184, Percent_Identity=27.1739130434783, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=188, Percent_Identity=31.3829787234043, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=181, Percent_Identity=29.2817679558011, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=185, Percent_Identity=27.027027027027, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=187, Percent_Identity=28.3422459893048, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=181, Percent_Identity=27.0718232044199, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=174, Percent_Identity=31.0344827586207, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=173, Percent_Identity=26.0115606936416, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=178, Percent_Identity=38.2022471910112, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI23397609, Length=173, Percent_Identity=36.4161849710983, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI28571526, Length=178, Percent_Identity=34.8314606741573, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24644339, Length=178, Percent_Identity=35.9550561797753, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355319, Length=177, Percent_Identity=33.8983050847458, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644337, Length=174, Percent_Identity=36.7816091954023, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24643142, Length=164, Percent_Identity=32.9268292682927, Blast_Score=93, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24639444, Length=169, Percent_Identity=32.5443786982249, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737361, Length=183, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.268 [H]

Molecular weight: Translated: 17952; Mature: 17821

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFGGLDVLVNNAGVAGRAAFDQPEAVEVWDRVIGVNLEGAFNVSHALVPALKAAKGNV
CCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
VHLCSVAGFVSGGSTAGYVVSKGAIRSLTQVMARDLAPHGIRVNAVAPGIMMSEVAVAQL
EEEEHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHC
NRPGGTDWFMNRVMMKRIGETSEVVDPVVFLASPMASYITGTILPVDGGFLAA
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECC
>Mature Secondary Structure 
SRFGGLDVLVNNAGVAGRAAFDQPEAVEVWDRVIGVNLEGAFNVSHALVPALKAAKGNV
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCE
VHLCSVAGFVSGGSTAGYVVSKGAIRSLTQVMARDLAPHGIRVNAVAPGIMMSEVAVAQL
EEEEHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHC
NRPGGTDWFMNRVMMKRIGETSEVVDPVVFLASPMASYITGTILPVDGGFLAA
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704278; 9405410; 12524213 [H]