BacMap

Definition	Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession	NC_012442
Length	1,185,518

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The map label for this gene is fabG [H]

Identifier: 225685898

GI number: 225685898

Start: 26368

End: 27105

Strand: Direct

Name: fabG [H]

Synonym: BMEA_B0032

Alternate gene names: 225685898

Gene position: 26368-27105 (Clockwise)

Preceding gene: 225685897

Following gene: 225685899

Centisome position: 2.22

GC content: 58.94

Gene sequence:

>738_bases
ATGAAATTCGAGTTTGAAAACCGGACGCTCGTTCTCACTGGCGCAAATGGCGGCATTGGCCGCGCGATTGCCGAACTGTT
CCATGCTTCCGGCGCCAATCTGGTTCTGACTGATCTGGACAGGGAAGGTCTCGACGCTTTCGCCGCATCGCTGGGCAGCC
CGGAACGAATTGCCACCATCAAGGCCGATGCGTCAAGCGCGGACGACGCCGAAAAGACCGTAGCGCTTGCCATGGAGCGT
TTCGGCGGCATCGATTTCCTTGTGCCATCGGTGGGTATCTATCAGGCGAAACCCTTCGCCGAAATGTCGGATGCCGACTG
GCACCGCACGATTTCGATCAATCTGGATGGCGTCTTCTATCTGTGCAAGCGCGCTTTGCCCGCCTTGAAGGAGGATTCCT
CCATCGTCACGCTGGCTTCGCTCGCGGCCTATCGCGGCGCTTATGTGAACGCGCATTACGGCGCGACCAAGGGCGCCATG
GTTTCCATGACCCGTGCGCTCTCGCGTGAGCTTGCGCCGAAAACCCGCGTCAATGGCGTTGCCCCCGGCATCATCGAAAC
CCCGATGACCAGCGAGCTTCTCAAGACGCGCATGGATGAAACCATGACACAGACGCCGCTGAAGCGGCTTGGCAAACCAT
CCGAAATTGCATCCGTCATTGCCTTCCTCTGTTCACCTGCCGCGAGCTTCGTCACGGGAGAAACGATCCAGGTGAATGGC
GGCATCTACATGGCCTGA

Upstream 100 bases:

>100_bases
GCTTGCCTTTTTGCACGACCCCGAAGGCCACATCGTCGAGATCGTCCAATACGACGACATTGCTGCCTATCGTCCCGATC
TGGCTGAGGAGAAATAATCG

Downstream 100 bases:

>100_bases
CCCCAAGGAAACCGAAAATAGAACTTCTGAAAGAAAAGCTCGTCCTCGTCACCGGTGCAGGCCGGGGGCTGGGAGCGGCG
ATTTCTTCCGGCGCGGCAGA

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADASSADDAEKTVALAMER
FGGIDFLVPSVGIYQAKPFAEMSDADWHRTISINLDGVFYLCKRALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAM
VSMTRALSRELAPKTRVNGVAPGIIETPMTSELLKTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQVNG
GIYMA

Sequences:

>Translated_245_residues
MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADASSADDAEKTVALAMER
FGGIDFLVPSVGIYQAKPFAEMSDADWHRTISINLDGVFYLCKRALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAM
VSMTRALSRELAPKTRVNGVAPGIIETPMTSELLKTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQVNG
GIYMA
>Mature_245_residues
MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADASSADDAEKTVALAMER
FGGIDFLVPSVGIYQAKPFAEMSDADWHRTISINLDGVFYLCKRALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAM
VSMTRALSRELAPKTRVNGVAPGIIETPMTSELLKTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQVNG
GIYMA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=35.3658536585366, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=32.2448979591837, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=31.4176245210728, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI19923817, Length=249, Percent_Identity=29.718875502008, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=33.4661354581673, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=30.5785123966942, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=30.7692307692308, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI59889578, Length=224, Percent_Identity=33.9285714285714, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI83715985, Length=250, Percent_Identity=32, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=35.2331606217617, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7705925, Length=252, Percent_Identity=30.1587301587302, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4504505, Length=251, Percent_Identity=27.0916334661355, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=28.2258064516129, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI109715829, Length=242, Percent_Identity=23.5537190082645, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI66933014, Length=247, Percent_Identity=23.8866396761134, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI142976729, Length=228, Percent_Identity=28.5087719298246, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=27.4725274725275, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4503817, Length=220, Percent_Identity=26.8181818181818, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI31542939, Length=208, Percent_Identity=27.4038461538462, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI310128830, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI310115468, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=37.246963562753, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=31.1740890688259, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082100, Length=251, Percent_Identity=32.2709163346614, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=31.9838056680162, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=28.7449392712551, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790717, Length=263, Percent_Identity=29.277566539924, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788459, Length=242, Percent_Identity=29.3388429752066, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=29.5833333333333, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=29.6442687747036, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=32.156862745098, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789057, Length=263, Percent_Identity=27.7566539923954, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788891, Length=244, Percent_Identity=27.4590163934426, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=242, Percent_Identity=33.0578512396694, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=32.4, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=33.7349397590361, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=29.8387096774194, Blast_Score=120, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI72000259, Length=256, Percent_Identity=29.6875, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562910, Length=258, Percent_Identity=30.2325581395349, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=29.8449612403101, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17563726, Length=256, Percent_Identity=28.125, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560332, Length=259, Percent_Identity=30.5019305019305, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=259, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560150, Length=256, Percent_Identity=27.734375, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562990, Length=256, Percent_Identity=27.734375, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=258, Percent_Identity=28.2945736434109, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.615969581749, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17568967, Length=255, Percent_Identity=25.4901960784314, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=26.5873015873016, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=260, Percent_Identity=25.7692307692308, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=27.5303643724696, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=28.0769230769231, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=26.9961977186312, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=26.3565891472868, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=26.2357414448669, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17564282, Length=191, Percent_Identity=27.7486910994764, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=27.5510204081633, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=249, Percent_Identity=27.710843373494, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=242, Percent_Identity=28.5123966942149, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17567345, Length=209, Percent_Identity=24.8803827751196, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508651, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=28.2258064516129, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322861, Length=252, Percent_Identity=28.968253968254, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=35.6846473029046, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=29.9595141700405, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=31.6, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=29.5081967213115, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24644339, Length=249, Percent_Identity=31.3253012048193, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=30.5220883534137, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=29.9610894941634, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=30, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI18859837, Length=237, Percent_Identity=28.2700421940928, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24644337, Length=250, Percent_Identity=33.2, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24665243, Length=226, Percent_Identity=28.3185840707965, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221331218, Length=223, Percent_Identity=28.2511210762332, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665247, Length=177, Percent_Identity=28.2485875706215, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221331216, Length=224, Percent_Identity=28.125, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24663911, Length=216, Percent_Identity=26.3888888888889, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 26070; Mature: 26070

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATI
CCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEE
KADASSADDAEKTVALAMERFGGIDFLVPSVGIYQAKPFAEMSDADWHRTISINLDGVFY
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHH
LCKRALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAMVSMTRALSRELAPKTRVNGV
HHHHHHHCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHCCCC
APGIIETPMTSELLKTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQVNG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCEEEECC
GIYMA
CEEEC
>Mature Secondary Structure
MKFEFENRTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATI
CCEEECCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCEEEE
KADASSADDAEKTVALAMERFGGIDFLVPSVGIYQAKPFAEMSDADWHRTISINLDGVFY
ECCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHH
LCKRALPALKEDSSIVTLASLAAYRGAYVNAHYGATKGAMVSMTRALSRELAPKTRVNGV
HHHHHHHCCCCCCCCHHHHHHHHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCHHCCCC
APGIIETPMTSELLKTRMDETMTQTPLKRLGKPSEIASVIAFLCSPAASFVTGETIQVNG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCEEEECC
GIYMA
CEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]