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The map label for this gene is pepA [H]

Identifier: 222526826

GI number: 222526826

Start: 4481858

End: 4483315

Strand: Direct

Name: pepA [H]

Synonym: Chy400_3601

Alternate gene names: 222526826

Gene position: 4481858-4483315 (Clockwise)

Preceding gene: 222526813

Following gene: 222526829

Centisome position: 85.06

GC content: 58.92

Gene sequence:

>1458_bases
ATGCAGTGCGAAGTACAGACCGGTGATCTGTTGGGGGTTACAGCGGATCTGGCGGTGTTGCTCTACGCTGAGGATGAGAC
TCTACCATCAGCGGTTGCAGCGCTATGTGAGCCTGAAGATACCACCGGACGCTGGCAGAGTCAGACACTTATCTATCCGC
GAGGAGCATTGCCGGCCCGTCGGTTGTTGTTGATCGGGATGGGGAAGCGTTCGGCCATTACGGCTGACACAGTCCGTCAG
GCGGCGGCGCTGGCTGTTCGCTATGCCCAGGATGCGAAGGTGGCAACATTCCATATCGGCTACAACGGCAATCTACCACT
GACACCGGCGGTGTTCGGGCAGGCATTTGCCGAGGGAAGTGTTCTGGGTGCGTATCGTTACACCCGCTACAAGAGTGACG
CCAAAGAGCAACCGACGCAGAAAGCCGTTTTGCAGGCCGCTACTGACGCTGATGCAGCGGCAGCCGGAGTACGCCGTGGT
CAGATCATCGCTCAGGCCACAGCGTTTGCCCGCGATCTGGCCAATGGCCCCGGTAATGATGTCACTCCAGCGTTCCTTGG
TCAAACCGCTCTTGCCTTGGGCGAGCGGTACGGCTTGAAGACAATGGTGCTCGATAAGGCGCAGTTGATCGAACAGGGCT
TCGGTGGCATCCTCGCCGTCGGTCAGGGTTCGGCCAATGAACCGCGCTTTATTGTGATGGAGTATGGCTCACCCGATCAA
GGGCCACCGATCTGCCTGGTCGGTAAAGGCATTACCTTCGACACCGGTGGGATCAGTATCAAACCGGCAGAGAAGATGGA
CGACATGAAGATGGATATGAGCGGTGCGGCTGCGGTGTTCGGCGCGATGCAGGCCGTCGCCGAATTGCAACTGCCGCTCT
ATGTCGTCGGTATTGTTTGTGCTGCCGAGAATATGCCGAGCGCGACGGCGTATCGCCCCGGCGACATTATCCGTACCCTC
AGCGGTAAGACGGTTGAAGTGCTGAATACGGATGCTGAAGGGCGGATCGTGCTGGCCGATGGTCTCTTCTACGCGCAGCG
CTACCAACCCGCTGCGATTGTCGATCTGGCGACGCTCACCGGTGCGATTATGATCGCCCTTGGCCCCCACGCGATTGGGA
TGATGGGGAACAATCAAGAGCTGGCCAATCGGCTGATTGCTGCCGGTGAAGCAACCGCCGAGCGCGTCTGGCAGTTGCCG
CTTTGGGACGAGTATCGCGATGCGATGAAGAGCGAGATCGCCGATCTCAAGAATACCGGTGGCCGCTATGGTGGTGCGAT
TACCGCAGCCGGTTTTCTGGCCGCGTTTGTCGGTGATTATCCGTGGGCGCACCTCGATATTGCCGGTACTGCCTGGGTAG
AAAAGCCGAACCGAACCTATCAGTCACGGGGGGCAACCGGGGTTGGTGTCCGGCTGTTGGTTGAGCTACTGCAAGGGTAC
GTGGGTCAGCAGTCATAA

Upstream 100 bases:

>100_bases
TGTCTGGCAGCCTGATCGGTTGCACGGATTTGACGGTCTGCCGCGCTCGACGTACAATGAAGAACCGGAAAAGATGACTT
GTCACCTATTTGAGGTTCCT

Downstream 100 bases:

>100_bases
CCTGAATAACGGCGGGGCAGGTTGTACATCTGCCCCGCTGGAGCGGACTCCAGGGGTGACGCAGGCGTCGCCCCTGGTTC
ATTTCTGGCGGGTAACGAAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MQCEVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPARRLLLIGMGKRSAITADTVRQ
AAALAVRYAQDAKVATFHIGYNGNLPLTPAVFGQAFAEGSVLGAYRYTRYKSDAKEQPTQKAVLQAATDADAAAAGVRRG
QIIAQATAFARDLANGPGNDVTPAFLGQTALALGERYGLKTMVLDKAQLIEQGFGGILAVGQGSANEPRFIVMEYGSPDQ
GPPICLVGKGITFDTGGISIKPAEKMDDMKMDMSGAAAVFGAMQAVAELQLPLYVVGIVCAAENMPSATAYRPGDIIRTL
SGKTVEVLNTDAEGRIVLADGLFYAQRYQPAAIVDLATLTGAIMIALGPHAIGMMGNNQELANRLIAAGEATAERVWQLP
LWDEYRDAMKSEIADLKNTGGRYGGAITAAGFLAAFVGDYPWAHLDIAGTAWVEKPNRTYQSRGATGVGVRLLVELLQGY
VGQQS

Sequences:

>Translated_485_residues
MQCEVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPARRLLLIGMGKRSAITADTVRQ
AAALAVRYAQDAKVATFHIGYNGNLPLTPAVFGQAFAEGSVLGAYRYTRYKSDAKEQPTQKAVLQAATDADAAAAGVRRG
QIIAQATAFARDLANGPGNDVTPAFLGQTALALGERYGLKTMVLDKAQLIEQGFGGILAVGQGSANEPRFIVMEYGSPDQ
GPPICLVGKGITFDTGGISIKPAEKMDDMKMDMSGAAAVFGAMQAVAELQLPLYVVGIVCAAENMPSATAYRPGDIIRTL
SGKTVEVLNTDAEGRIVLADGLFYAQRYQPAAIVDLATLTGAIMIALGPHAIGMMGNNQELANRLIAAGEATAERVWQLP
LWDEYRDAMKSEIADLKNTGGRYGGAITAAGFLAAFVGDYPWAHLDIAGTAWVEKPNRTYQSRGATGVGVRLLVELLQGY
VGQQS
>Mature_485_residues
MQCEVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPARRLLLIGMGKRSAITADTVRQ
AAALAVRYAQDAKVATFHIGYNGNLPLTPAVFGQAFAEGSVLGAYRYTRYKSDAKEQPTQKAVLQAATDADAAAAGVRRG
QIIAQATAFARDLANGPGNDVTPAFLGQTALALGERYGLKTMVLDKAQLIEQGFGGILAVGQGSANEPRFIVMEYGSPDQ
GPPICLVGKGITFDTGGISIKPAEKMDDMKMDMSGAAAVFGAMQAVAELQLPLYVVGIVCAAENMPSATAYRPGDIIRTL
SGKTVEVLNTDAEGRIVLADGLFYAQRYQPAAIVDLATLTGAIMIALGPHAIGMMGNNQELANRLIAAGEATAERVWQLP
LWDEYRDAMKSEIADLKNTGGRYGGAITAAGFLAAFVGDYPWAHLDIAGTAWVEKPNRTYQSRGATGVGVRLLVELLQGY
VGQQS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=431, Percent_Identity=39.2111368909513, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI47155554, Length=381, Percent_Identity=34.3832020997375, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1790710, Length=467, Percent_Identity=42.3982869379015, Blast_Score=338, Evalue=5e-94,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=42.3676012461059, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=316, Percent_Identity=38.9240506329114, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17565172, Length=354, Percent_Identity=27.683615819209, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355725, Length=406, Percent_Identity=32.2660098522167, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24661038, Length=367, Percent_Identity=32.9700272479564, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662227, Length=384, Percent_Identity=32.2916666666667, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129969, Length=373, Percent_Identity=32.9758713136729, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355645, Length=378, Percent_Identity=30.6878306878307, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24662223, Length=378, Percent_Identity=30.6878306878307, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI19922386, Length=383, Percent_Identity=30.8093994778068, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI161077148, Length=366, Percent_Identity=31.1475409836066, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20130057, Length=366, Percent_Identity=31.1475409836066, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129963, Length=344, Percent_Identity=31.6860465116279, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=36.1904761904762, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=36.1904761904762, Blast_Score=168, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=36.1904761904762, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24646701, Length=345, Percent_Identity=29.5652173913043, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24646703, Length=345, Percent_Identity=29.5652173913043, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21358201, Length=345, Percent_Identity=29.5652173913043, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51238; Mature: 51238

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQCEVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPAR
CCCCCCCCCEEEEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCC
RLLLIGMGKRSAITADTVRQAAALAVRYAQDAKVATFHIGYNGNLPLTPAVFGQAFAEGS
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCC
VLGAYRYTRYKSDAKEQPTQKAVLQAATDADAAAAGVRRGQIIAQATAFARDLANGPGND
EEEHHHHHHHCCCHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
VTPAFLGQTALALGERYGLKTMVLDKAQLIEQGFGGILAVGQGSANEPRFIVMEYGSPDQ
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCC
GPPICLVGKGITFDTGGISIKPAEKMDDMKMDMSGAAAVFGAMQAVAELQLPLYVVGIVC
CCCEEEEECCEEECCCCEEECCHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AAENMPSATAYRPGDIIRTLSGKTVEVLNTDAEGRIVLADGLFYAQRYQPAAIVDLATLT
HCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECCEEHHHHCCCHHHHHHHHHH
GAIMIALGPHAIGMMGNNQELANRLIAAGEATAERVWQLPLWDEYRDAMKSEIADLKNTG
HEEEEEECCCEEEECCCCHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHCC
GRYGGAITAAGFLAAFVGDYPWAHLDIAGTAWVEKPNRTYQSRGATGVGVRLLVELLQGY
CCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHH
VGQQS
CCCCC
>Mature Secondary Structure
MQCEVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPAR
CCCCCCCCCEEEEEEEEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCC
RLLLIGMGKRSAITADTVRQAAALAVRYAQDAKVATFHIGYNGNLPLTPAVFGQAFAEGS
EEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCC
VLGAYRYTRYKSDAKEQPTQKAVLQAATDADAAAAGVRRGQIIAQATAFARDLANGPGND
EEEHHHHHHHCCCHHCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCC
VTPAFLGQTALALGERYGLKTMVLDKAQLIEQGFGGILAVGQGSANEPRFIVMEYGSPDQ
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCC
GPPICLVGKGITFDTGGISIKPAEKMDDMKMDMSGAAAVFGAMQAVAELQLPLYVVGIVC
CCCEEEEECCEEECCCCEEECCHHHHCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
AAENMPSATAYRPGDIIRTLSGKTVEVLNTDAEGRIVLADGLFYAQRYQPAAIVDLATLT
HCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECCEEHHHHCCCHHHHHHHHHH
GAIMIALGPHAIGMMGNNQELANRLIAAGEATAERVWQLPLWDEYRDAMKSEIADLKNTG
HEEEEEECCCEEEECCCCHHHHHHHHHCCCHHHHHEECCCCHHHHHHHHHHHHHHHHHCC
GRYGGAITAAGFLAAFVGDYPWAHLDIAGTAWVEKPNRTYQSRGATGVGVRLLVELLQGY
CCCCCHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCHHHHCCCCCHHHHHHHHHHHHH
VGQQS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA