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The map label for this gene is hemB [H]

Identifier: 222526048

GI number: 222526048

Start: 3456209

End: 3457267

Strand: Direct

Name: hemB [H]

Synonym: Chy400_2805

Alternate gene names: 222526048

Gene position: 3456209-3457267 (Clockwise)

Preceding gene: 222526047

Following gene: 222526049

Centisome position: 65.6

GC content: 60.15

Gene sequence:

>1059_bases
GTGGATGTGCTCTCACGTCATACACCGGCTACGAATGGCACAACGACACAGGTACCAACGCCGGTTCACCGTCCGCGCCG
GTTGCGGATCAGTCCGGCCATGCGCGATCTGGTGCGCGAAACTCGCCTGACACCGGCCCAGTTGATTGCCCCGATCTTTG
TCCGTCACGGCCATAACCTGCGCAATCCGATTGCCTCGATGCCCGGTCAGTACCAGATGTCACCCGACCAGGCTGCCCGC
GAAGCACGCGAGCTGGCGGCGCTCGGGATTCGGGCCGTGCTCCTGTTTGGGATTCCGGCCCACAAGGATCCGTGTGGTAG
CGAGAATGCCGACCCGGCGGGGATTGTACCCCAGGCCATCCAGGCCATCAAAGCTGAAGTGCCGGGAATGGTGGTTATTA
GCGATATGTGCTTCTGCGAGTACACCGATCACGGTCACTGTGGTGTGCTCAACACACCGACCCGCGATGATTTTCAACCG
CAGTTGGGTGAAGGGTACCTGCTTAATGATCCAACCCTGGCGCTGCTGGCCGAAGCATCGATAGTGCATGCCCGTGCCGG
AGCCGATATTATTGCCCCTTCTGGCATGATCGATGGCATGGTGGCGGCGATTCGCTCGGCGCTGGACGCTGCGGGGCTGA
GCCATACCGCGATCATGAGCTATGCCGCAAAGTATGCCAGCGGTTTTTATGGCCCCTTCCGCGATGCTGCCGAAAGTCCG
CCTCAGTTCGGTGATCGGAGCCAGTACCAGATGGATCCGGCCAATGCGCGTGAAGCACTGCGTGAAGTCGATCTCGATGT
GGCGGAGGGAGCAGATATCTTGATGGTCAAACCGGCACTCGCCTACCTCGACATTATCCGGCAGGTGCGCGACCGCCATA
CATTGCCGCTGGCAGCGTATCAGGTGAGCGGCGAGTACAGTATGGTGAAGGCCGCAGCATTACAGGGCTGGCTCGACGAG
CAGCGGATTGCGTTGGAGATGCTGACCGCTATTCGACGTGCCGGCGCTGACATGATTATCACCTATTGGGCCAGAGAAGC
CGCCGAATGGCTTGGATGA

Upstream 100 bases:

>100_bases
CTCCCCATTGCGGGTATTGCCGAACGTCCAAACGACGATGCGCTGATTGCTGTGCTTGAACAGGTTTTTACACCGTATTG
TGAAGTGAAGGAGTAAGGCT

Downstream 100 bases:

>100_bases
CTGGTGCTGAGCGAGGTCTTCAATCCGCGCTCAGCAGCGTCAACGCGGGGGAAGGGATTGCACCACCGAGGTACCAAGGA
TACAGAGATGAGATGATGAA

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MDVLSRHTPATNGTTTQVPTPVHRPRRLRISPAMRDLVRETRLTPAQLIAPIFVRHGHNLRNPIASMPGQYQMSPDQAAR
EARELAALGIRAVLLFGIPAHKDPCGSENADPAGIVPQAIQAIKAEVPGMVVISDMCFCEYTDHGHCGVLNTPTRDDFQP
QLGEGYLLNDPTLALLAEASIVHARAGADIIAPSGMIDGMVAAIRSALDAAGLSHTAIMSYAAKYASGFYGPFRDAAESP
PQFGDRSQYQMDPANAREALREVDLDVAEGADILMVKPALAYLDIIRQVRDRHTLPLAAYQVSGEYSMVKAAALQGWLDE
QRIALEMLTAIRRAGADMIITYWAREAAEWLG

Sequences:

>Translated_352_residues
MDVLSRHTPATNGTTTQVPTPVHRPRRLRISPAMRDLVRETRLTPAQLIAPIFVRHGHNLRNPIASMPGQYQMSPDQAAR
EARELAALGIRAVLLFGIPAHKDPCGSENADPAGIVPQAIQAIKAEVPGMVVISDMCFCEYTDHGHCGVLNTPTRDDFQP
QLGEGYLLNDPTLALLAEASIVHARAGADIIAPSGMIDGMVAAIRSALDAAGLSHTAIMSYAAKYASGFYGPFRDAAESP
PQFGDRSQYQMDPANAREALREVDLDVAEGADILMVKPALAYLDIIRQVRDRHTLPLAAYQVSGEYSMVKAAALQGWLDE
QRIALEMLTAIRRAGADMIITYWAREAAEWLG
>Mature_352_residues
MDVLSRHTPATNGTTTQVPTPVHRPRRLRISPAMRDLVRETRLTPAQLIAPIFVRHGHNLRNPIASMPGQYQMSPDQAAR
EARELAALGIRAVLLFGIPAHKDPCGSENADPAGIVPQAIQAIKAEVPGMVVISDMCFCEYTDHGHCGVLNTPTRDDFQP
QLGEGYLLNDPTLALLAEASIVHARAGADIIAPSGMIDGMVAAIRSALDAAGLSHTAIMSYAAKYASGFYGPFRDAAESP
PQFGDRSQYQMDPANAREALREVDLDVAEGADILMVKPALAYLDIIRQVRDRHTLPLAAYQVSGEYSMVKAAALQGWLDE
QRIALEMLTAIRRAGADMIITYWAREAAEWLG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=315, Percent_Identity=44.4444444444444, Blast_Score=252, Evalue=3e-67,
Organism=Escherichia coli, GI87081728, Length=328, Percent_Identity=51.5243902439024, Blast_Score=313, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6321398, Length=325, Percent_Identity=41.8461538461538, Blast_Score=239, Evalue=7e-64,
Organism=Drosophila melanogaster, GI21358291, Length=307, Percent_Identity=41.3680781758958, Blast_Score=228, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 38212; Mature: 38212

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVLSRHTPATNGTTTQVPTPVHRPRRLRISPAMRDLVRETRLTPAQLIAPIFVRHGHNL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
RNPIASMPGQYQMSPDQAAREARELAALGIRAVLLFGIPAHKDPCGSENADPAGIVPQAI
HCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
QAIKAEVPGMVVISDMCFCEYTDHGHCGVLNTPTRDDFQPQLGEGYLLNDPTLALLAEAS
HHHHHCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHH
IVHARAGADIIAPSGMIDGMVAAIRSALDAAGLSHTAIMSYAAKYASGFYGPFRDAAESP
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
PQFGDRSQYQMDPANAREALREVDLDVAEGADILMVKPALAYLDIIRQVRDRHTLPLAAY
CCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCEEEE
QVSGEYSMVKAAALQGWLDEQRIALEMLTAIRRAGADMIITYWAREAAEWLG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MDVLSRHTPATNGTTTQVPTPVHRPRRLRISPAMRDLVRETRLTPAQLIAPIFVRHGHNL
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
RNPIASMPGQYQMSPDQAAREARELAALGIRAVLLFGIPAHKDPCGSENADPAGIVPQAI
HCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
QAIKAEVPGMVVISDMCFCEYTDHGHCGVLNTPTRDDFQPQLGEGYLLNDPTLALLAEAS
HHHHHCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHH
IVHARAGADIIAPSGMIDGMVAAIRSALDAAGLSHTAIMSYAAKYASGFYGPFRDAAESP
HHHHHCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHCCC
PQFGDRSQYQMDPANAREALREVDLDVAEGADILMVKPALAYLDIIRQVRDRHTLPLAAY
CCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCEEEECHHHHHHHHHHHHHHCCCCCEEEE
QVSGEYSMVKAAALQGWLDEQRIALEMLTAIRRAGADMIITYWAREAAEWLG
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]