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The map label for this gene is hemD [H]

Identifier: 222526047

GI number: 222526047

Start: 3455452

End: 3456204

Strand: Direct

Name: hemD [H]

Synonym: Chy400_2804

Alternate gene names: 222526047

Gene position: 3455452-3456204 (Clockwise)

Preceding gene: 222526046

Following gene: 222526048

Centisome position: 65.58

GC content: 60.56

Gene sequence:

>753_bases
ATGAGTGGACTGGTTGGTCGTCGAATCGCCATCACGCGCCCGGCCGGACGTGGCGATACGCTGGCTGCACGCTTGCAGGC
GCTTGGTGCGATTCCACTTCTGACGCCACTGATTGCCTATATGCCGCCTCCCGATCCGGCACCATTGCAGCAGGCGCTCA
ATCGTCTGGCTACTGGTGCGTATCACTGGCTGGTCGTGACCAGCCGGCAGACGGTGCAGGTGTTAGCTGACACCACAATT
CCTGAATCGACCGCCATTGCAGCGGTTGGCAAAGCGACTGCCAGCGATTGTCGGCGGGCCTGGGGGCGCGAACCTACAGT
TGTTCCTGATACCGAGATCGGCAGTGCCTTGCCGGCGATCATGGGGCAGCTTGCCGGGAAGCGTGTCTTGTTGCCCTGCG
CGGATATTGCTCCGCCAACTCTCACTGAAGCGCTTCGCGCTGCCGGTGCCGACGTTGATCGGGTTACCGCCTATTGCACC
GTGGCCGGCCCTGGCCTTGCCGATTTGCAACGTATGATCGATGACGGTGCGATTGACGCTATCGTGCTCGCCAGTGGTTC
GGCAGTTCGCCAGTTGCAGCAGCTTCACGTACCGACCGGCTTGCCGCCACTGGTCTGCATTGGCCCCAGCACGGCTGCCG
TTTGCGCTGATCTAGGGCTCCCCATTGCGGGTATTGCCGAACGTCCAAACGACGATGCGCTGATTGCTGTGCTTGAACAG
GTTTTTACACCGTATTGTGAAGTGAAGGAGTAA

Upstream 100 bases:

>100_bases
CACAGGCCGAAGCGTTGGGAGTGGCGGTTGCCGAAGAATTGCTGGCTCGCGGCGGTGACGCGATTCTCACCGCTATCCGT
CATCAGTTGGAGGCACGACG

Downstream 100 bases:

>100_bases
GGCTGTGGATGTGCTCTCACGTCATACACCGGCTACGAATGGCACAACGACACAGGTACCAACGCCGGTTCACCGTCCGC
GCCGGTTGCGGATCAGTCCG

Product: Uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Uroporphyrinogen-III synthase; UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGAYHWLVVTSRQTVQVLADTTI
PESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAIMGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCT
VAGPGLADLQRMIDDGAIDAIVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQ
VFTPYCEVKE

Sequences:

>Translated_250_residues
MSGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGAYHWLVVTSRQTVQVLADTTI
PESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAIMGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCT
VAGPGLADLQRMIDDGAIDAIVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQ
VFTPYCEVKE
>Mature_249_residues
SGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGAYHWLVVTSRQTVQVLADTTIP
ESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAIMGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCTV
AGPGLADLQRMIDDGAIDAIVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQV
FTPYCEVKE

Specific function: May catalyze sequential reactions to synthesize uroporphyrinogen III from hydroxymethylbilane (HMB) and then precorrin-2, which are intermediate compounds in both vitamin B12 and siroheme biosyntheses [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR003754
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF02602 HEM4; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =4.2.1.75 [H]

Molecular weight: Translated: 25870; Mature: 25739

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGA
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
YHWLVVTSRQTVQVLADTTIPESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAI
EEEEEEECCHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCTVAGPGLADLQRMIDDGAIDA
HHHHCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHEEEEEECCCCHHHHHHHHCCCCCCE
IVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQ
EEEECCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCHHCCCCCCHHHHHHHHH
VFTPYCEVKE
HHCCCCCCCC
>Mature Secondary Structure 
SGLVGRRIAITRPAGRGDTLAARLQALGAIPLLTPLIAYMPPPDPAPLQQALNRLATGA
CCCCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
YHWLVVTSRQTVQVLADTTIPESTAIAAVGKATASDCRRAWGREPTVVPDTEIGSALPAI
EEEEEEECCHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
MGQLAGKRVLLPCADIAPPTLTEALRAAGADVDRVTAYCTVAGPGLADLQRMIDDGAIDA
HHHHCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHEEEEEECCCCHHHHHHHHCCCCCCE
IVLASGSAVRQLQQLHVPTGLPPLVCIGPSTAAVCADLGLPIAGIAERPNDDALIAVLEQ
EEEECCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHCCCCCHHCCCCCCHHHHHHHHH
VFTPYCEVKE
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7665501 [H]