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The map label for this gene is hemC [H]

Identifier: 222526046

GI number: 222526046

Start: 3454481

End: 3455455

Strand: Direct

Name: hemC [H]

Synonym: Chy400_2803

Alternate gene names: 222526046

Gene position: 3454481-3455455 (Clockwise)

Preceding gene: 222526045

Following gene: 222526047

Centisome position: 65.56

GC content: 61.54

Gene sequence:

>975_bases
ATGGCACGTTTATTGCTTGGTACTCGTGGTTCGGCACTTGCCCGTGTTCAGTCCGTGTGGGTTGCCGACGCGCTCCGCAC
GGCCTTTCCCTCATTAGAGGTTGAGCTGCGGATTATTTCGACCACCGGTGATCGGGTGCTCGATGTGGCCTTGTCGGCGG
TCGGTGATAAAGGTCTGTTCGTGAAAGAACTTGAGCATGCCTTGCTGGCCAGTGAGGTTGATCTGTGCGTACATAGCGCA
AAAGATATGCCGACGGCGACCCCGGATGGTCTGGTGTTGGCGGCGTTTCCGGTGCGCGTTGATCCGCGTGATGTGCTGGT
TGTCCGTCAGGCCGGTTTGGGCACCGATCTCGCTACGTTGCCTGCCGGTGCACGGGTGGGCACGTCAAGCCTGCGGCGAA
CCAGTCAGGTGCGCCATCATCGGCCCGATCTGCAATTGACTGACGTTCGGGGCAATGTTGATACGCGCCTGCGTAAACTG
GCCTCCGGTCAGTACGATGCGCTCATTCTGGCTGCGGCCGGGTTGCGGCGGCTGGGTTTGTGGGATGGCACCCCCGGCGC
ACAGATCGGCGAAGCGGTTGTGTATCCGCTTGAGCCATCGGTGATGCTGCCGGCGGTGGCGCAGGGTATTCTGGCTATCG
AGACCCGCGCCGATGATGAGGCAACGCGCACGCTGGTAGAGTCACTTGACGATCCGGCAGCCAGAGCAGCGGCACTCGCT
GAACGTGCGCTGTTGCGCCGTCTGGAAGGTGGCTGTCAGATTCCGGTGGCAGCTCACGCGGTTATGACCGATACCGGTAT
GCATCTGCGCGGGATGGTTGGTACTCTCGATGGCAGTACGCTGGTGTTTGCCGAGCAGACCGGTGACCCGGCACAGGCCG
AAGCGTTGGGAGTGGCGGTTGCCGAAGAATTGCTGGCTCGCGGCGGTGACGCGATTCTCACCGCTATCCGTCATCAGTTG
GAGGCACGACGATGA

Upstream 100 bases:

>100_bases
CGCCTACCCGTTGCCTGCGCGAAGCCGCCGCGCATGGTCAGGGCAAACGCTATGCTTCCATTCTGGCCGAACTCTTTAAT
CTGGAGCATTGAGAGGAGTT

Downstream 100 bases:

>100_bases
GTGGACTGGTTGGTCGTCGAATCGCCATCACGCGCCCGGCCGGACGTGGCGATACGCTGGCTGCACGCTTGCAGGCGCTT
GGTGCGATTCCACTTCTGAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MARLLLGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLFVKELEHALLASEVDLCVHSA
KDMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATLPAGARVGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKL
ASGQYDALILAAAGLRRLGLWDGTPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALA
ERALLRRLEGGCQIPVAAHAVMTDTGMHLRGMVGTLDGSTLVFAEQTGDPAQAEALGVAVAEELLARGGDAILTAIRHQL
EARR

Sequences:

>Translated_324_residues
MARLLLGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLFVKELEHALLASEVDLCVHSA
KDMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATLPAGARVGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKL
ASGQYDALILAAAGLRRLGLWDGTPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALA
ERALLRRLEGGCQIPVAAHAVMTDTGMHLRGMVGTLDGSTLVFAEQTGDPAQAEALGVAVAEELLARGGDAILTAIRHQL
EARR
>Mature_323_residues
ARLLLGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLFVKELEHALLASEVDLCVHSAK
DMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATLPAGARVGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKLA
SGQYDALILAAAGLRRLGLWDGTPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALAE
RALLRRLEGGCQIPVAAHAVMTDTGMHLRGMVGTLDGSTLVFAEQTGDPAQAEALGVAVAEELLARGGDAILTAIRHQLE
ARR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=348, Percent_Identity=41.6666666666667, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI66933009, Length=342, Percent_Identity=42.1052631578947, Blast_Score=238, Evalue=7e-63,
Organism=Escherichia coli, GI48994974, Length=315, Percent_Identity=46.3492063492063, Blast_Score=246, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6319996, Length=326, Percent_Identity=34.6625766871166, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20130425, Length=285, Percent_Identity=41.4035087719298, Blast_Score=197, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34188; Mature: 34057

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLLLGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLF
CCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCHH
VKELEHALLASEVDLCVHSAKDMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCHHHC
PAGARVGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKLASGQYDALILAAAGLRRLGL
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEHEEHHHHHHCCC
WDGTPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALA
CCCCCCCCCCCEEEECCCCCEEHHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHH
ERALLRRLEGGCQIPVAAHAVMTDTGMHLRGMVGTLDGSTLVFAEQTGDPAQAEALGVAV
HHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
AEELLARGGDAILTAIRHQLEARR
HHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ARLLLGTRGSALARVQSVWVADALRTAFPSLEVELRIISTTGDRVLDVALSAVGDKGLF
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHCCCCCHH
VKELEHALLASEVDLCVHSAKDMPTATPDGLVLAAFPVRVDPRDVLVVRQAGLGTDLATL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCHHHC
PAGARVGTSSLRRTSQVRHHRPDLQLTDVRGNVDTRLRKLASGQYDALILAAAGLRRLGL
CCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCEEHEEHHHHHHCCC
WDGTPGAQIGEAVVYPLEPSVMLPAVAQGILAIETRADDEATRTLVESLDDPAARAAALA
CCCCCCCCCCCEEEECCCCCEEHHHHHCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHH
ERALLRRLEGGCQIPVAAHAVMTDTGMHLRGMVGTLDGSTLVFAEQTGDPAQAEALGVAV
HHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHH
AEELLARGGDAILTAIRHQLEARR
HHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA