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The map label for this gene is hemA [H]

Identifier: 222526045

GI number: 222526045

Start: 3453168

End: 3454472

Strand: Direct

Name: hemA [H]

Synonym: Chy400_2802

Alternate gene names: 222526045

Gene position: 3453168-3454472 (Clockwise)

Preceding gene: 222526044

Following gene: 222526046

Centisome position: 65.54

GC content: 58.85

Gene sequence:

>1305_bases
ATGAATCTGTTCCTTGCCGGTCTCGATCATACGACTGCGCCGGTTGAGATTCGCGAACAACTTGCCTTCAGCCAGACTGA
TTTGCCTTCAGCCCTGATGCAATTGACCAGTTCAGAAACCGGCACGCCGCCGCTCTTTGCCGAGGCCGTGATTCTTTCGA
CCTGCAATCGAGTTGAATTGTACGGTGTAACGAACCCTGGAACGACGGCCCAACACGTTGTCGATTTTCTGGCCGCTTTT
CACCGTCGTCCAGCCGCGAGCTTTGTCCACACGCTCTATTTTTACCAGGGTGAAGCCGTTGCCCGTCATTTGTGTGCAAC
TGCCGCCGGGTTACGTTCGCTGGTTTTGGGAGAGGCCCAAATTCAGGGTCAGGTGCGCAATGCCTACGAAGCGGCGCAAC
GGATCGGCAGTGTCGGTTCGATCTTGCACCGTCTGTTTCAGATTGCCCTGGTCGCCGGGAAACGGGTGCGCCACGAAACG
ACTATCGGGAAAGGGGCGGCGAGTGTTTCGCAGGCCGGTGTTGAGCTTGCCCGTCGTCGGCTCGGTGATCTACGGGGCCG
TGAGGTGTTGTTGATCGGCGGCGGTGAGGTGAGCGAGCTTGCCGCCCAGAATCTGATCGCCAACGGTGCTGATCGATTGA
CGATTGTCAATCGCACGTCGGCGCGTGCTGCCGCCCTGGCCGAACGCTACGGTGCTGAGATGCTTGATTTCGGTGCTCTA
CCCCAGGCGTTGGCCCGCGCCGACATTGTCATTAGCTCGACCGCAGCACCGGTACCGATTATTTACCGCCATCACGTGGC
CGAGGCGATTGCCCATAAACAGCGGGCTCGCGCCTGTGGTGAGTGCGATCCGCCGACGATGTTGTTGATCGATCTGGCCG
TGCCCCGCGACATTGCGGCTGATGTCGCCCAGATTCCCGGTGTACACCTCTTCACGGTTGATGATCTGCGTGAGGTTGTG
AGTCATACGATTGAGTTGCGGAGCGCAGTCCTGGAGATTGCCCAACAGATTGTTGAAGAGCAGGTGCAGGAGTTTCTGTC
CTGGATGCGTACCCAGGAGGCCCTGCCGGTACTGACAATGTTGCGCCAGCGGGCTGAGGAGGTACGGAATGAGGAACTGG
CCCGTGCCTTGCGTCGCTTGCACGATCTCTCACCCGAACAGCGGGCAGTCATTGAAGGGCTGTCGCGGAGTATCGTGAAC
AAGCTGTTGCACCCGCCTACCCGTTGCCTGCGCGAAGCCGCCGCGCATGGTCAGGGCAAACGCTATGCTTCCATTCTGGC
CGAACTCTTTAATCTGGAGCATTGA

Upstream 100 bases:

>100_bases
CGGGCGGGCGGGGTTTTTGTCGCCATCCGCCTGTCTGGATACAATGGTTCACCATTCGGTGTCTTGCCGTGAGCATTTTG
CAAAGCAAAGGATCAGGAGT

Downstream 100 bases:

>100_bases
GAGGAGTTATGGCACGTTTATTGCTTGGTACTCGTGGTTCGGCACTTGCCCGTGTTCAGTCCGTGTGGGTTGCCGACGCG
CTCCGCACGGCCTTTCCCTC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MNLFLAGLDHTTAPVEIREQLAFSQTDLPSALMQLTSSETGTPPLFAEAVILSTCNRVELYGVTNPGTTAQHVVDFLAAF
HRRPAASFVHTLYFYQGEAVARHLCATAAGLRSLVLGEAQIQGQVRNAYEAAQRIGSVGSILHRLFQIALVAGKRVRHET
TIGKGAASVSQAGVELARRRLGDLRGREVLLIGGGEVSELAAQNLIANGADRLTIVNRTSARAAALAERYGAEMLDFGAL
PQALARADIVISSTAAPVPIIYRHHVAEAIAHKQRARACGECDPPTMLLIDLAVPRDIAADVAQIPGVHLFTVDDLREVV
SHTIELRSAVLEIAQQIVEEQVQEFLSWMRTQEALPVLTMLRQRAEEVRNEELARALRRLHDLSPEQRAVIEGLSRSIVN
KLLHPPTRCLREAAAHGQGKRYASILAELFNLEH

Sequences:

>Translated_434_residues
MNLFLAGLDHTTAPVEIREQLAFSQTDLPSALMQLTSSETGTPPLFAEAVILSTCNRVELYGVTNPGTTAQHVVDFLAAF
HRRPAASFVHTLYFYQGEAVARHLCATAAGLRSLVLGEAQIQGQVRNAYEAAQRIGSVGSILHRLFQIALVAGKRVRHET
TIGKGAASVSQAGVELARRRLGDLRGREVLLIGGGEVSELAAQNLIANGADRLTIVNRTSARAAALAERYGAEMLDFGAL
PQALARADIVISSTAAPVPIIYRHHVAEAIAHKQRARACGECDPPTMLLIDLAVPRDIAADVAQIPGVHLFTVDDLREVV
SHTIELRSAVLEIAQQIVEEQVQEFLSWMRTQEALPVLTMLRQRAEEVRNEELARALRRLHDLSPEQRAVIEGLSRSIVN
KLLHPPTRCLREAAAHGQGKRYASILAELFNLEH
>Mature_434_residues
MNLFLAGLDHTTAPVEIREQLAFSQTDLPSALMQLTSSETGTPPLFAEAVILSTCNRVELYGVTNPGTTAQHVVDFLAAF
HRRPAASFVHTLYFYQGEAVARHLCATAAGLRSLVLGEAQIQGQVRNAYEAAQRIGSVGSILHRLFQIALVAGKRVRHET
TIGKGAASVSQAGVELARRRLGDLRGREVLLIGGGEVSELAAQNLIANGADRLTIVNRTSARAAALAERYGAEMLDFGAL
PQALARADIVISSTAAPVPIIYRHHVAEAIAHKQRARACGECDPPTMLLIDLAVPRDIAADVAQIPGVHLFTVDDLREVV
SHTIELRSAVLEIAQQIVEEQVQEFLSWMRTQEALPVLTMLRQRAEEVRNEELARALRRLHDLSPEQRAVIEGLSRSIVN
KLLHPPTRCLREAAAHGQGKRYASILAELFNLEH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=434, Percent_Identity=37.5576036866359, Blast_Score=266, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 47297; Mature: 47297

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLFLAGLDHTTAPVEIREQLAFSQTDLPSALMQLTSSETGTPPLFAEAVILSTCNRVEL
CCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
YGVTNPGTTAQHVVDFLAAFHRRPAASFVHTLYFYQGEAVARHLCATAAGLRSLVLGEAQ
EECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGQVRNAYEAAQRIGSVGSILHRLFQIALVAGKRVRHETTIGKGAASVSQAGVELARRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LGDLRGREVLLIGGGEVSELAAQNLIANGADRLTIVNRTSARAAALAERYGAEMLDFGAL
HHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCHHHHHHCCH
PQALARADIVISSTAAPVPIIYRHHVAEAIAHKQRARACGECDPPTMLLIDLAVPRDIAA
HHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHH
DVAQIPGVHLFTVDDLREVVSHTIELRSAVLEIAQQIVEEQVQEFLSWMRTQEALPVLTM
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQRAEEVRNEELARALRRLHDLSPEQRAVIEGLSRSIVNKLLHPPTRCLREAAAHGQGK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
RYASILAELFNLEH
HHHHHHHHHHCCCC
>Mature Secondary Structure
MNLFLAGLDHTTAPVEIREQLAFSQTDLPSALMQLTSSETGTPPLFAEAVILSTCNRVEL
CCEEEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
YGVTNPGTTAQHVVDFLAAFHRRPAASFVHTLYFYQGEAVARHLCATAAGLRSLVLGEAQ
EECCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQGQVRNAYEAAQRIGSVGSILHRLFQIALVAGKRVRHETTIGKGAASVSQAGVELARRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LGDLRGREVLLIGGGEVSELAAQNLIANGADRLTIVNRTSARAAALAERYGAEMLDFGAL
HHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCHHHHHHCCH
PQALARADIVISSTAAPVPIIYRHHVAEAIAHKQRARACGECDPPTMLLIDLAVPRDIAA
HHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHH
DVAQIPGVHLFTVDDLREVVSHTIELRSAVLEIAQQIVEEQVQEFLSWMRTQEALPVLTM
HHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRQRAEEVRNEELARALRRLHDLSPEQRAVIEGLSRSIVNKLLHPPTRCLREAAAHGQGK
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
RYASILAELFNLEH
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA