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The map label for this gene is ilvA [H]

Identifier: 222526037

GI number: 222526037

Start: 3440653

End: 3442170

Strand: Reverse

Name: ilvA [H]

Synonym: Chy400_2794

Alternate gene names: 222526037

Gene position: 3442170-3440653 (Counterclockwise)

Preceding gene: 222526038

Following gene: 222526036

Centisome position: 65.33

GC content: 57.25

Gene sequence:

>1518_bases
ATGCCCAACCCTGATTTTACCTACGTTCAACGCATCCTGACCAGTCGGGTCTATGATGTTGTCAAAGAGACCCCATTGCA
ACATGCGCCTCTTCTCAGCGCCCGCCTGGGAGCACAGATCTTTTTCAAACGTGAGGATCTGTTGCCCATCTTCTCTTTTA
AGCTCCGTGGTGCCTATAACCGCATGGCTCATCTCAGTCCTGCCGAGAAAGAACGCGGCGTCATCACAGCCTCTGCCGGC
AATCACGCCCAGGGAGTCGCCTTTTCTGGCCAGCAGCTCGGCGTGCGCACGCTGATTGTCATGCCGGCAACCACCCCAGA
GATCAAGGTGGCAGCCTGTCGGCGTCGGAATGCAGAAGTTGTCCTGTACGGCGACAGCTATAGTGACGCTGAAGCGCACG
CCTACCGCTTACAGCAAGAATTGGGCTTAACCTTCATCCATCCCTACGACGATCCGCTGGTGATTGCCGGTCAGGGTACG
ATTGGGCTGGAGATTTCCCAACAGATGCGCGCCGAGCGATACCGTGTCTTCGTGCCGGTAGGTGGCGGCGGTCTGATTGC
CGGCATCGCGATCTTCTTGAAGAGCATCAATCCCAATATTGAGATCATTGCCGTCGAGCCAGATGACTCTGATGCGATGT
ACCAGAGCGTCCGGGCCGGCTATCGGGTCACCCTTGATCAGGTCGGAATCTTTGTTGATGGCGTGGCAGTTCGGCGGGTT
GGCGAACACACCTTTGCGATTGTTCAGCGCTACGTCGATGATTTTGTGCGGGTGACAACCGACGAGGTCTGTGCGGCGAT
CAAAGATGTCTTTGAGGACACCCGGGCCATTATGGAGCCAGCCGGCGCGCTGGCCGTCGCCGGGTTAAAGCGCTATATCG
CCGAACACGGGGCCGATCTACCGGCAGTAGCCTTAACGTGTGGCGCTAACATGAACTTTGACCGTCTGCGCCACGTTGCC
GAACGGGCCGAAATTGGCGAACGGCGTGAGGCGTTGTTTGCTGTGACCATCCCTGAACGACCCGGCTCATTCAAGCAATT
TTGTCGCGTGATCGGACCACACAATATCACCGAATTCAACTACCGCTATGCACCGCGCCCCGAAGCCAATGTCTTTGTGG
GTGTACAACTGACCAATGCCAATCAGCGCCACGAGCTGGCCGAACGTATGCGCAACGCCGGTTATACGGTGCTTGACCTG
ACCAACGACGAGCTGGCAATCATTCATCTACGCCACATGGTTGGTGGACGAGCACCCGAAGCAACCGACGAACGGCTCTT
CACCTTCGAGTTCCCGGAGCGACCGGGAGCGCTCTTGCAATTTCTCGAGTCGCTCGATGCCTCGTGGAACATCAGCCTCT
TCCACTACCGCAACCATGGCAGCGCCCATGGGCGGGTACTGGCCGGTATTCAGGTGCCCGATGCCGATCTCGACCGTTTC
TACGCCTCACTGGCTCGCCTGGGATACCCGTATCAGGAGCAGAGTGATAATCCGGCGTACCACCTGTTTTTGAAATGA

Upstream 100 bases:

>100_bases
CCCGATCCATCTTCACTGATTGCCGACGCTGATCGCGCGCTCTACCTGGCCAAACAACAGGGGCGCAATCGCGTCTGCGG
TGTACAGGAGCTGACCAACG

Downstream 100 bases:

>100_bases
GCAACGCCCCCGGTAGAGCCGGGTGGCGGAGCGATTGAGCGCCACGATTGAACAGAATGCCCGTCGCACCAGATGGTGTG
ACGGGCAGTGCAGAGTTTAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MPNPDFTYVQRILTSRVYDVVKETPLQHAPLLSARLGAQIFFKREDLLPIFSFKLRGAYNRMAHLSPAEKERGVITASAG
NHAQGVAFSGQQLGVRTLIVMPATTPEIKVAACRRRNAEVVLYGDSYSDAEAHAYRLQQELGLTFIHPYDDPLVIAGQGT
IGLEISQQMRAERYRVFVPVGGGGLIAGIAIFLKSINPNIEIIAVEPDDSDAMYQSVRAGYRVTLDQVGIFVDGVAVRRV
GEHTFAIVQRYVDDFVRVTTDEVCAAIKDVFEDTRAIMEPAGALAVAGLKRYIAEHGADLPAVALTCGANMNFDRLRHVA
ERAEIGERREALFAVTIPERPGSFKQFCRVIGPHNITEFNYRYAPRPEANVFVGVQLTNANQRHELAERMRNAGYTVLDL
TNDELAIIHLRHMVGGRAPEATDERLFTFEFPERPGALLQFLESLDASWNISLFHYRNHGSAHGRVLAGIQVPDADLDRF
YASLARLGYPYQEQSDNPAYHLFLK

Sequences:

>Translated_505_residues
MPNPDFTYVQRILTSRVYDVVKETPLQHAPLLSARLGAQIFFKREDLLPIFSFKLRGAYNRMAHLSPAEKERGVITASAG
NHAQGVAFSGQQLGVRTLIVMPATTPEIKVAACRRRNAEVVLYGDSYSDAEAHAYRLQQELGLTFIHPYDDPLVIAGQGT
IGLEISQQMRAERYRVFVPVGGGGLIAGIAIFLKSINPNIEIIAVEPDDSDAMYQSVRAGYRVTLDQVGIFVDGVAVRRV
GEHTFAIVQRYVDDFVRVTTDEVCAAIKDVFEDTRAIMEPAGALAVAGLKRYIAEHGADLPAVALTCGANMNFDRLRHVA
ERAEIGERREALFAVTIPERPGSFKQFCRVIGPHNITEFNYRYAPRPEANVFVGVQLTNANQRHELAERMRNAGYTVLDL
TNDELAIIHLRHMVGGRAPEATDERLFTFEFPERPGALLQFLESLDASWNISLFHYRNHGSAHGRVLAGIQVPDADLDRF
YASLARLGYPYQEQSDNPAYHLFLK
>Mature_504_residues
PNPDFTYVQRILTSRVYDVVKETPLQHAPLLSARLGAQIFFKREDLLPIFSFKLRGAYNRMAHLSPAEKERGVITASAGN
HAQGVAFSGQQLGVRTLIVMPATTPEIKVAACRRRNAEVVLYGDSYSDAEAHAYRLQQELGLTFIHPYDDPLVIAGQGTI
GLEISQQMRAERYRVFVPVGGGGLIAGIAIFLKSINPNIEIIAVEPDDSDAMYQSVRAGYRVTLDQVGIFVDGVAVRRVG
EHTFAIVQRYVDDFVRVTTDEVCAAIKDVFEDTRAIMEPAGALAVAGLKRYIAEHGADLPAVALTCGANMNFDRLRHVAE
RAEIGERREALFAVTIPERPGSFKQFCRVIGPHNITEFNYRYAPRPEANVFVGVQLTNANQRHELAERMRNAGYTVLDLT
NDELAIIHLRHMVGGRAPEATDERLFTFEFPERPGALLQFLESLDASWNISLFHYRNHGSAHGRVLAGIQVPDADLDRFY
ASLARLGYPYQEQSDNPAYHLFLK

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=278, Percent_Identity=35.9712230215827, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=27.1028037383178, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI19923959, Length=316, Percent_Identity=27.2151898734177, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790207, Length=499, Percent_Identity=51.7034068136273, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=38.6292834890966, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=331, Percent_Identity=32.9305135951662, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=279, Percent_Identity=30.8243727598566, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17537387, Length=337, Percent_Identity=30.5637982195846, Blast_Score=133, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320930, Length=519, Percent_Identity=47.3988439306358, Blast_Score=463, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=275, Percent_Identity=37.8181818181818, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=319, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355833, Length=315, Percent_Identity=33.3333333333333, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645328, Length=251, Percent_Identity=32.2709163346614, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56269; Mature: 56138

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPDFTYVQRILTSRVYDVVKETPLQHAPLLSARLGAQIFFKREDLLPIFSFKLRGAYN
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHCCHHH
RMAHLSPAEKERGVITASAGNHAQGVAFSGQQLGVRTLIVMPATTPEIKVAACRRRNAEV
HHHCCCCCHHHCCEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCEEHHHHHCCCCEE
VLYGDSYSDAEAHAYRLQQELGLTFIHPYDDPLVIAGQGTIGLEISQQMRAERYRVFVPV
EEECCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHHHCCCCEEEEEEE
GGGGLIAGIAIFLKSINPNIEIIAVEPDDSDAMYQSVRAGYRVTLDQVGIFVDGVAVRRV
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHHCEEECCHHHHHH
GEHTFAIVQRYVDDFVRVTTDEVCAAIKDVFEDTRAIMEPAGALAVAGLKRYIAEHGADL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PAVALTCGANMNFDRLRHVAERAEIGERREALFAVTIPERPGSFKQFCRVIGPHNITEFN
CEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEECC
YRYAPRPEANVFVGVQLTNANQRHELAERMRNAGYTVLDLTNDELAIIHLRHMVGGRAPE
EEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHCCCCCC
ATDERLFTFEFPERPGALLQFLESLDASWNISLFHYRNHGSAHGRVLAGIQVPDADLDRF
CCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCCHHHHH
YASLARLGYPYQEQSDNPAYHLFLK
HHHHHHHCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
PNPDFTYVQRILTSRVYDVVKETPLQHAPLLSARLGAQIFFKREDLLPIFSFKLRGAYN
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEEECCCCCHHHHHHHCCHHH
RMAHLSPAEKERGVITASAGNHAQGVAFSGQQLGVRTLIVMPATTPEIKVAACRRRNAEV
HHHCCCCCHHHCCEEEECCCCCCCCEEECCCCCCEEEEEEECCCCCCEEHHHHHCCCCEE
VLYGDSYSDAEAHAYRLQQELGLTFIHPYDDPLVIAGQGTIGLEISQQMRAERYRVFVPV
EEECCCCCCHHHHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEHHHHCCCCEEEEEEE
GGGGLIAGIAIFLKSINPNIEIIAVEPDDSDAMYQSVRAGYRVTLDQVGIFVDGVAVRRV
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCEEEHHHHCEEECCHHHHHH
GEHTFAIVQRYVDDFVRVTTDEVCAAIKDVFEDTRAIMEPAGALAVAGLKRYIAEHGADL
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
PAVALTCGANMNFDRLRHVAERAEIGERREALFAVTIPERPGSFKQFCRVIGPHNITEFN
CEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEECC
YRYAPRPEANVFVGVQLTNANQRHELAERMRNAGYTVLDLTNDELAIIHLRHMVGGRAPE
EEECCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHCCCCCC
ATDERLFTFEFPERPGALLQFLESLDASWNISLFHYRNHGSAHGRVLAGIQVPDADLDRF
CCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEECCCCHHHHH
YASLARLGYPYQEQSDNPAYHLFLK
HHHHHHHCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA