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The map label for this gene is lon

Identifier: 222524147

GI number: 222524147

Start: 1090254

End: 1092737

Strand: Reverse

Name: lon

Synonym: Chy400_0863

Alternate gene names: 222524147

Gene position: 1092737-1090254 (Counterclockwise)

Preceding gene: 222524148

Following gene: 222524144

Centisome position: 20.74

GC content: 60.35

Gene sequence:

>2484_bases
ATGAATGATGAAACATTGCGGGAACAGACGACTGCGGAGTCTGAAGAGACATCACCAACGACACCTTCACCCGAACCAGA
GGTGGTTGAGACGCTGCCCCTCATTCCGTTAGAGGGAGCGGTCGTTTTTCCTTATATTGTGGTCAGCCTGACGCTCGATG
AGTTGGGGTCGGCGTCAGCCGAAGCCGCAGCGCGCGAGGGGCGTCAGGTGTTGCTGGCTGCCCGGCGGCCCGATGCGCCT
GCCGATGCGCCGATTACCGACCAGCTCTTCAATGTAGGGGTAGTGGCCCGGATCGAGCAGCTCGGTACCTTGCCGAATGG
TGCCAGCGGGGTGGTCGTGCGGGGGCTGGTGCGTGCTGTGCTGGGTGAAGCCGTCCAAACCACGCCGTATCTGCGTTTTC
GCTTTACCCGCCGACCCGATGTCTTCGAGCGCACTCCGGAGCTTGAGCAGTTAATGGTCGAGGTTCACGCCGCGATTGAC
GCGGTGCTCGAATTGCGCCCCGGCGTGACGCAAGAGATTCGCAATTTTGTCCGCTCCATCGACGATCCCGGTCATCTGGC
CGACAACACCGGCTATTCGCCCGATTACACCTTCGCCGAGCGCCAGGAATTGCTCGAAACCTTCGACGTAAGCGAGCGGT
TGCGCAAGGTGCTGATGTTTTACCGCAAACAGTTCGCCCTACTCGAAGTTCAGGCCAAACTGCGGCAAGAGGTGCAGGAG
AGTGCGGCCCGGCAGCAACGCGAATTCTACCTGCGCCAGCAATTGCGCGCTATTCAGAAAGAGCTTGGCGAAGATACGAG
TGAAGCCGCGGAACTTGACGATCTCCGGCAGAAGCTGGCCGCTGCCGATCTGCCTGAAGTTGCCCGTAAAGAGGCCGACC
GTGAGCTGAGTCGTCTGGCCCGGATCAATGCCAGCTCACCGGAATATCAGATGGTACGTACCTACCTGGAGTGGCTGGCT
GAGCTGCCGTGGAATAAGTATACCGGCCAGCCAATTGATATTGCCTTTGCCCGCCAGGTGCTTGATGAAGATCATCACGG
CCTCCAGAAGGTCAAAGAGCGGATTCTGGAATATCTGGCAGTGAAGCAACGTCGGGCAGCGTTGGGTGAAGAGAACCTGC
GTGCCAATCGCGAGCCAATTCTCGCCTTTGTTGGGCCACCCGGCGTGGGCAAGACCAGTCTGGGGCAGAGTATTGCCCGT
GCGCTTGGCCGGAGCTTCGTCCGTATGAGCCTCGGTGGTGTACGTGATGAGGCCGAGCTGCGTGGTTTCCGCCGAACGTA
CATTGGTTCGCAGCCGGGGCGGATCATCCAGGAGCTGCGCCGTGCCGGTACTGCCGACCCGGTGATCTTGCTGGATGAAA
TCGATAAGCTGGGGATCGATTATCGCGGTGATCCGGCAGCCGCACTGCTTGAGGTGCTTGATCCCGAACAAAATCACACC
TTCACCGATCACTATCTCAATCTGCCGTTCGATCTCTCACGTGTCCTCTTCCTGGCAACGGCCAACACGTGGGATACGGT
ACCGCCGGCGTTACGTGACCGGATGGAGGTGATTGAGCTATCGGGGTATATCGAAGACGAGAAGGTGCAGATTGCCCAGA
TTCATCTGGTGCCGCGCCAGTTGCGGGCCAACGGCTTGCGCCCGGAAGAGGCTGTCGTCACCGAAGACGCCATTCGCTGC
ATCATTAATGAGTACACACGCGAAGCCGGTGTCCGGAATCTGGAGCGTTCGATTGGTGCGGTGCTGCGCAAGGTGGCCCG
TCGCCTGAGCGAAGGCGAGATCGATCCGGCCAATACGCCGTTTGTGGTCGATGCTGCGTTTGTGCGCGCCGCGCTGGGGC
GGCCACGCTTCACCAATGAAACCCGCGAACGGATCGATCAGCCCGGTGTGGCGATTGGCCTGGTATGGACACCGGTCGGC
GGCGATATTATCTTTGTGGAGGCCAGTGCGGTTGAAGGGAAGAAAGAACTTACAATCACCGGCCAACTGGGTGAGGTCAT
GCGCGAGAGTGCCGAAGCGGCGCTGACCTACGTCCGTTCGCGCGCCCGTTCGCTGGGCATCGAGCCGGATTTCTTCGAGA
CCCACGCCATTCACATTCACGTGCCGGCTGGTGCGGTGCCCAAAGATGGCCCCTCAGCCGGTATTACGATGGCAACCGCC
CTGGCGTCGGCGGCAACCGGTCGGCTGGTGCGTGACGATATTGCCATGACCGGCGAAATCTCACTGCGTGGGCGGGTGTT
GCCGATTGGCGGCATCAAAGAGAAGGCACTCGGCGCTCACCGGGCCGGTATCCGCACTGTGATCCTGCCCAGGCGGAATC
TGATCGATCTCGACGACCTGCCGCCGGCGGTTAGCGCCGAAATGACCTTCATTCCGGTAGACACCCTTGATGAGGTATTG
AGCATCGCCCTTCTGCCGCCGGCGACGACCACAGATACGCTCACTGTGGCGCAGCGGAGTGATGTGCTCACCCCGGCATC
CTGA

Upstream 100 bases:

>100_bases
ACACTAGAACTTTTGTCCCATCATTGACACGCTCCACTATGAGTTTCAAAATATACATAGTGCGGAAGTCTTGTTCCGCG
GATCAATGTGGAGACGTGCT

Downstream 100 bases:

>100_bases
GTTTAGGGATGGACAGACTATTTGAATGCATCTTTCAGTGCATCAGGAAGCTATAAACAAAGCCTCTGAACGCCCCTCTC
CCGCGCTGCGCGGGAGAGGG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASAEAAAREGRQVLLAARRPDAP
ADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAVLGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAID
AVLELRPGVTQEIRNFVRSIDDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQE
SAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLARINASSPEYQMVRTYLEWLA
ELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLAVKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIAR
ALGRSFVRMSLGGVRDEAELRGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHT
FTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQLRANGLRPEEAVVTEDAIRC
IINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTPFVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVG
GDIIFVEASAVEGKKELTITGQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATA
LASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDLPPAVSAEMTFIPVDTLDEVL
SIALLPPATTTDTLTVAQRSDVLTPAS

Sequences:

>Translated_827_residues
MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASAEAAAREGRQVLLAARRPDAP
ADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAVLGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAID
AVLELRPGVTQEIRNFVRSIDDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQE
SAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLARINASSPEYQMVRTYLEWLA
ELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLAVKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIAR
ALGRSFVRMSLGGVRDEAELRGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHT
FTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQLRANGLRPEEAVVTEDAIRC
IINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTPFVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVG
GDIIFVEASAVEGKKELTITGQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATA
LASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDLPPAVSAEMTFIPVDTLDEVL
SIALLPPATTTDTLTVAQRSDVLTPAS
>Mature_827_residues
MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASAEAAAREGRQVLLAARRPDAP
ADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAVLGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAID
AVLELRPGVTQEIRNFVRSIDDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQE
SAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLARINASSPEYQMVRTYLEWLA
ELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLAVKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIAR
ALGRSFVRMSLGGVRDEAELRGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHT
FTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQLRANGLRPEEAVVTEDAIRC
IINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTPFVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVG
GDIIFVEASAVEGKKELTITGQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATA
LASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDLPPAVSAEMTFIPVDTLDEVL
SIALLPPATTTDTLTVAQRSDVLTPAS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=784, Percent_Identity=41.3265306122449, Blast_Score=577, Evalue=1e-164,
Organism=Homo sapiens, GI21396489, Length=678, Percent_Identity=42.7728613569322, Blast_Score=548, Evalue=1e-155,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=46.1340206185567, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=664, Percent_Identity=39.1566265060241, Blast_Score=476, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=544, Percent_Identity=43.1985294117647, Blast_Score=444, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319449, Length=721, Percent_Identity=37.7253814147018, Blast_Score=502, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=689, Percent_Identity=41.6545718432511, Blast_Score=529, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24666867, Length=689, Percent_Identity=41.6545718432511, Blast_Score=529, Evalue=1e-150,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_CHLAA (A9WGB5)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001634425.1
- ProteinModelPortal:   A9WGB5
- GeneID:   5824830
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0798
- HOGENOM:   HBG566281
- OMA:   HYTLLVT
- ProtClustDB:   CLSK973577
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91353; Mature: 91353

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 712-712 ACT_SITE 755-755

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASA
CCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
EAAAREGRQVLLAARRPDAPADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAV
HHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAIDAVLELRPGVTQEIRNFVRSI
HHHHHHCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RINASSPEYQMVRTYLEWLAELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLA
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIARALGRSFVRMSLGGVRDEAEL
HHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHT
HHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCCC
FTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQ
CCHHEECCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHH
LRANGLRPEEAVVTEDAIRCIINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVGGDIIFVEASAVEGKKELTIT
EEEHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEE
GQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
LASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDL
HHHHHHCCHHHHHHCEECEEEECCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCCCC
PPAVSAEMTFIPVDTLDEVLSIALLPPATTTDTLTVAQRSDVLTPAS
CCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MNDETLREQTTAESEETSPTTPSPEPEVVETLPLIPLEGAVVFPYIVVSLTLDELGSASA
CCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHH
EAAAREGRQVLLAARRPDAPADAPITDQLFNVGVVARIEQLGTLPNGASGVVVRGLVRAV
HHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LGEAVQTTPYLRFRFTRRPDVFERTPELEQLMVEVHAAIDAVLELRPGVTQEIRNFVRSI
HHHHHHCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
DDPGHLADNTGYSPDYTFAERQELLETFDVSERLRKVLMFYRKQFALLEVQAKLRQEVQE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAARQQREFYLRQQLRAIQKELGEDTSEAAELDDLRQKLAAADLPEVARKEADRELSRLA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RINASSPEYQMVRTYLEWLAELPWNKYTGQPIDIAFARQVLDEDHHGLQKVKERILEYLA
HCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
VKQRRAALGEENLRANREPILAFVGPPGVGKTSLGQSIARALGRSFVRMSLGGVRDEAEL
HHHHHHHCCHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
RGFRRTYIGSQPGRIIQELRRAGTADPVILLDEIDKLGIDYRGDPAAALLEVLDPEQNHT
HHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECHHHCCCCCCCCHHHHHHHHHCCCCCCC
FTDHYLNLPFDLSRVLFLATANTWDTVPPALRDRMEVIELSGYIEDEKVQIAQIHLVPRQ
CCHHEECCCHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHH
LRANGLRPEEAVVTEDAIRCIINEYTREAGVRNLERSIGAVLRKVARRLSEGEIDPANTP
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
FVVDAAFVRAALGRPRFTNETRERIDQPGVAIGLVWTPVGGDIIFVEASAVEGKKELTIT
EEEHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEEEECCCCCEEEEEECCCCCCCEEEEE
GQLGEVMRESAEAALTYVRSRARSLGIEPDFFETHAIHIHVPAGAVPKDGPSAGITMATA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCCCHHHHHH
LASAATGRLVRDDIAMTGEISLRGRVLPIGGIKEKALGAHRAGIRTVILPRRNLIDLDDL
HHHHHHCCHHHHHHCEECEEEECCEEEECCCCHHHHHHHHHCCCEEEEECCCCCCCCCCC
PPAVSAEMTFIPVDTLDEVLSIALLPPATTTDTLTVAQRSDVLTPAS
CCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA