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The map label for this gene is lon [H]

Identifier: 222523621

GI number: 222523621

Start: 392540

End: 394912

Strand: Reverse

Name: lon [H]

Synonym: Chy400_0327

Alternate gene names: 222523621

Gene position: 394912-392540 (Counterclockwise)

Preceding gene: 222523622

Following gene: 222523620

Centisome position: 7.5

GC content: 59.17

Gene sequence:

>2373_bases
GTGAATGATCCAAACCCAATGCAACGTCCGCCTATGCCGGAGATACCGGATGTCTTGCCGGTATTGCCGATTAACAACGC
GATCCTGTTCCCCGGCATGTTTTTGCCGCTGGTGGTGAGTGGTGAAGCCTGGGTACGGCTGGTTGACGAGGCAGCACTCT
CTACCAAGATCATCGGCGTCTTCCGCCGCATTCAGTCCGGCGCCGAGTTTGAGCCGGAGATGCTGGCCCAGACCGGCACG
GCAGCCTTAATTGTGCGGATGATGCGCCTGCCCCAGGGTGGCGTGCAACTGTTGTTGCAAGGGCAGGCCCGGATCAAGGT
GCAGCGGTGGGTGACCGTCAAGCCATATCCCCAGGCGCACGTTACGGTCGCTCTCGATCCAGTTGATGTTTCGATGGAGA
CCACCGGCCTGGCGCGAGCGGTACTGGCAGGTTTCCAGCAGATCGTTGAGCAAAGTCCGAATTTGCCCGATGAACTGGCG
ATTGCCGCCGCGAACGCTCCCCATCCGGGCATGCTGGCCGATCTGATCGCGGCCAACCTGAATCTGAATCTCGACGATCA
GCAAAAGGTTCTCGACACGTTTGATGTGCATGAGCGGCTGCAACTGGTGTTGCGTCTGCTTGAGCGTGAGCGCGAAATCC
TGTTAATTGGCCGCAAAGCCCAGGAAGAGGTCTCGAAGAACCAGCGCGAATACGTGTTACGGCAACAGCTCGAGGCAATC
AAGCGCGAGCTAGGCGAAACCGATGATCATGCCGCTGAAATTGCCGAGTTGCGGCGGCGCATCGAAGAGGCCAATCTACC
GGCTGAAGCCCGTCAGGAAGCAGAGCGCGAGCTGTTGCGCCTTGAACGGATGCCCCCTGGCGCAGCCGAATACACCGTTG
CCCGCACCTACCTCGACTGGCTGCTCGATCTGCCGTGGCACACCAGCACCGAGGACAATCTCGATATTACCCAGGCCCGC
CAGGTACTTGATGAAGACCACTACGATCTCGAACGCATCAAAGAGCGGATTATCGAGTATCTGGCGGTACGCAAATTACG
CCGGGAAGAAGGTGCTGACAACGAGGCGCGTGGTCCGATCCTCTGCTTCGTCGGTCCGCCCGGCGTGGGCAAGACGAGTC
TGGGCGCGTCAATTGCCCGGGCGTTAGGGCGTAAGTTTGTCCGGGTTGCCCTCGGTGGTGTACGCGATGAGGCCGAAATT
CGTGGTCATCGTCGCACTTACATCGGTGCCCTGCCCGGTCGGATTATCCAGGGGCTGAGTCGGGCCAAGAGTAACAATCC
GGTGCTGCTGCTCGATGAGGTGGATAAGCTCAGCATCGGCTTTCAGGGCGATCCGGCAGCGGCACTACTCGAAGTGCTCG
ATCCTGAACAGAATGTCGCGTTCGTTGATCGTTACCTGGATGTACCGTTTGATCTGAGTAAAGTACTCTTTGTTTGTACG
GCCAACCGGGCTGATACCATCCCGCCGGCGTTGCTCGACCGGATGGAACTGCTGGAACTTGCCGGTTACACCGAACAAGA
AAAGCTGGAAATAGCCCGTCGCTATCTCATCCCGCGCCAGCGCCGTGAACAGGGCATGACAAATCGCGGGCCAGAGTTGA
CCACAGCCGCCTTGCAGCGTCTCATTCGCGAATACACGCATGAAGCCGGCGTTCGTGATCTGGAACGGCGGATTGGGGCG
ATCTATCGCAAGATGGCGACCCGTCTGGCCTCGGAACAGACGCTACCCGATCAGGTTGATGCGGCTGATCTCGACGACCT
GCTAGGGCCGCCGCGCTTCCGCAGCGAGACCATCCTCGGCGACAATGAAGTGGGGGTGGTTACCGGGCTGGCCTGGACAC
CGACCGGCGGTGACGTGCTCTTCGTTGAGGTGAGTGTCATTCCGGGCAATGGTCAGCTCATCCTGACCGGTCAATTGGGT
GATGTGATGAAAGAATCGGCGCGGGCCGCCCTGACCTACGCCCGTTCGCGCGCATCCGCTCTGGGTATCGATCCAGAGGT
CTTCCAGAAGAGTGACATTCACATTCACGTGCCGGCCGGTGCTGTGCCGAAAGATGGCCCATCGGCAGGCATCACCATCG
CCAGTGCGCTCATCTCGGCGCTGACCAGACGCGAAGTTGACAAACGGATCGCGATGACCGGTGAAGTAACCCTCCGTGGC
AAGGTATTGCCTATCGGCGGTGTCAAAGAAAAACTACTTGCCGCGCAGCGGGCCGGTGTGCGCAAAGTTCTGCTCCCTAC
CGAAAACGAGATCGACCTTCGCGACGTACCTGCCGAAACGAAGGAGCAGTTGGAGATTGTGCTGGTCAAGCATATGGACG
AGGTACTGCACGAACTGGGTCTGGAAATTGCCCCGCAACCGGTGAGTGAGTAA

Upstream 100 bases:

>100_bases
CCAGTGCTCGCTCGGTGCATGGGTTGCTTGAGATTCGCCTGCCCTTTGCCGGACGTACACTACGCCAGGTCGTTATTCCA
GTGCTGGAGGGAGAACAATC

Downstream 100 bases:

>100_bases
TCGAGCGACACGCTAGTGGATTGGCGTCGGCGTAGGGGCGACGCATGCGTCGCCCCTACACCTGTCATCGAATTTGATAT
GATGTCCAGCCTGAAGCCCG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 790; Mature: 790

Protein sequence:

>790_residues
MNDPNPMQRPPMPEIPDVLPVLPINNAILFPGMFLPLVVSGEAWVRLVDEAALSTKIIGVFRRIQSGAEFEPEMLAQTGT
AALIVRMMRLPQGGVQLLLQGQARIKVQRWVTVKPYPQAHVTVALDPVDVSMETTGLARAVLAGFQQIVEQSPNLPDELA
IAAANAPHPGMLADLIAANLNLNLDDQQKVLDTFDVHERLQLVLRLLEREREILLIGRKAQEEVSKNQREYVLRQQLEAI
KRELGETDDHAAEIAELRRRIEEANLPAEARQEAERELLRLERMPPGAAEYTVARTYLDWLLDLPWHTSTEDNLDITQAR
QVLDEDHYDLERIKERIIEYLAVRKLRREEGADNEARGPILCFVGPPGVGKTSLGASIARALGRKFVRVALGGVRDEAEI
RGHRRTYIGALPGRIIQGLSRAKSNNPVLLLDEVDKLSIGFQGDPAAALLEVLDPEQNVAFVDRYLDVPFDLSKVLFVCT
ANRADTIPPALLDRMELLELAGYTEQEKLEIARRYLIPRQRREQGMTNRGPELTTAALQRLIREYTHEAGVRDLERRIGA
IYRKMATRLASEQTLPDQVDAADLDDLLGPPRFRSETILGDNEVGVVTGLAWTPTGGDVLFVEVSVIPGNGQLILTGQLG
DVMKESARAALTYARSRASALGIDPEVFQKSDIHIHVPAGAVPKDGPSAGITIASALISALTRREVDKRIAMTGEVTLRG
KVLPIGGVKEKLLAAQRAGVRKVLLPTENEIDLRDVPAETKEQLEIVLVKHMDEVLHELGLEIAPQPVSE

Sequences:

>Translated_790_residues
MNDPNPMQRPPMPEIPDVLPVLPINNAILFPGMFLPLVVSGEAWVRLVDEAALSTKIIGVFRRIQSGAEFEPEMLAQTGT
AALIVRMMRLPQGGVQLLLQGQARIKVQRWVTVKPYPQAHVTVALDPVDVSMETTGLARAVLAGFQQIVEQSPNLPDELA
IAAANAPHPGMLADLIAANLNLNLDDQQKVLDTFDVHERLQLVLRLLEREREILLIGRKAQEEVSKNQREYVLRQQLEAI
KRELGETDDHAAEIAELRRRIEEANLPAEARQEAERELLRLERMPPGAAEYTVARTYLDWLLDLPWHTSTEDNLDITQAR
QVLDEDHYDLERIKERIIEYLAVRKLRREEGADNEARGPILCFVGPPGVGKTSLGASIARALGRKFVRVALGGVRDEAEI
RGHRRTYIGALPGRIIQGLSRAKSNNPVLLLDEVDKLSIGFQGDPAAALLEVLDPEQNVAFVDRYLDVPFDLSKVLFVCT
ANRADTIPPALLDRMELLELAGYTEQEKLEIARRYLIPRQRREQGMTNRGPELTTAALQRLIREYTHEAGVRDLERRIGA
IYRKMATRLASEQTLPDQVDAADLDDLLGPPRFRSETILGDNEVGVVTGLAWTPTGGDVLFVEVSVIPGNGQLILTGQLG
DVMKESARAALTYARSRASALGIDPEVFQKSDIHIHVPAGAVPKDGPSAGITIASALISALTRREVDKRIAMTGEVTLRG
KVLPIGGVKEKLLAAQRAGVRKVLLPTENEIDLRDVPAETKEQLEIVLVKHMDEVLHELGLEIAPQPVSE
>Mature_790_residues
MNDPNPMQRPPMPEIPDVLPVLPINNAILFPGMFLPLVVSGEAWVRLVDEAALSTKIIGVFRRIQSGAEFEPEMLAQTGT
AALIVRMMRLPQGGVQLLLQGQARIKVQRWVTVKPYPQAHVTVALDPVDVSMETTGLARAVLAGFQQIVEQSPNLPDELA
IAAANAPHPGMLADLIAANLNLNLDDQQKVLDTFDVHERLQLVLRLLEREREILLIGRKAQEEVSKNQREYVLRQQLEAI
KRELGETDDHAAEIAELRRRIEEANLPAEARQEAERELLRLERMPPGAAEYTVARTYLDWLLDLPWHTSTEDNLDITQAR
QVLDEDHYDLERIKERIIEYLAVRKLRREEGADNEARGPILCFVGPPGVGKTSLGASIARALGRKFVRVALGGVRDEAEI
RGHRRTYIGALPGRIIQGLSRAKSNNPVLLLDEVDKLSIGFQGDPAAALLEVLDPEQNVAFVDRYLDVPFDLSKVLFVCT
ANRADTIPPALLDRMELLELAGYTEQEKLEIARRYLIPRQRREQGMTNRGPELTTAALQRLIREYTHEAGVRDLERRIGA
IYRKMATRLASEQTLPDQVDAADLDDLLGPPRFRSETILGDNEVGVVTGLAWTPTGGDVLFVEVSVIPGNGQLILTGQLG
DVMKESARAALTYARSRASALGIDPEVFQKSDIHIHVPAGAVPKDGPSAGITIASALISALTRREVDKRIAMTGEVTLRG
KVLPIGGVKEKLLAAQRAGVRKVLLPTENEIDLRDVPAETKEQLEIVLVKHMDEVLHELGLEIAPQPVSE

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=834, Percent_Identity=39.9280575539568, Blast_Score=574, Evalue=1e-163,
Organism=Homo sapiens, GI21396489, Length=623, Percent_Identity=46.0674157303371, Blast_Score=554, Evalue=1e-157,
Organism=Escherichia coli, GI1786643, Length=765, Percent_Identity=46.6666666666667, Blast_Score=671, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=716, Percent_Identity=39.6648044692737, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17556486, Length=539, Percent_Identity=43.2282003710575, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319449, Length=722, Percent_Identity=38.9196675900277, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=624, Percent_Identity=45.6730769230769, Blast_Score=540, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24666867, Length=624, Percent_Identity=45.6730769230769, Blast_Score=540, Evalue=1e-153,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 87458; Mature: 87458

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPNPMQRPPMPEIPDVLPVLPINNAILFPGMFLPLVVSGEAWVRLVDEAALSTKIIGV
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHEECCHHHHHHHHHHHHHHHHHHH
FRRIQSGAEFEPEMLAQTGTAALIVRMMRLPQGGVQLLLQGQARIKVQRWVTVKPYPQAH
HHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCCCHHEEECCCCEEEEEEEEEECCCCCCE
VTVALDPVDVSMETTGLARAVLAGFQQIVEQSPNLPDELAIAAANAPHPGMLADLIAANL
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHCC
NLNLDDQQKVLDTFDVHERLQLVLRLLEREREILLIGRKAQEEVSKNQREYVLRQQLEAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KRELGETDDHAAEIAELRRRIEEANLPAEARQEAERELLRLERMPPGAAEYTVARTYLDW
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLDLPWHTSTEDNLDITQARQVLDEDHYDLERIKERIIEYLAVRKLRREEGADNEARGPI
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
LCFVGPPGVGKTSLGASIARALGRKFVRVALGGVRDEAEIRGHRRTYIGALPGRIIQGLS
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
RAKSNNPVLLLDEVDKLSIGFQGDPAAALLEVLDPEQNVAFVDRYLDVPFDLSKVLFVCT
HCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHEEE
ANRADTIPPALLDRMELLELAGYTEQEKLEIARRYLIPRQRREQGMTNRGPELTTAALQR
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHH
LIREYTHEAGVRDLERRIGAIYRKMATRLASEQTLPDQVDAADLDDLLGPPRFRSETILG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
DNEVGVVTGLAWTPTGGDVLFVEVSVIPGNGQLILTGQLGDVMKESARAALTYARSRASA
CCCCEEEEEEEECCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LGIDPEVFQKSDIHIHVPAGAVPKDGPSAGITIASALISALTRREVDKRIAMTGEVTLRG
CCCCHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECEEEEEE
KVLPIGGVKEKLLAAQRAGVRKVLLPTENEIDLRDVPAETKEQLEIVLVKHMDEVLHELG
EEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
LEIAPQPVSE
CEECCCCCCC
>Mature Secondary Structure
MNDPNPMQRPPMPEIPDVLPVLPINNAILFPGMFLPLVVSGEAWVRLVDEAALSTKIIGV
CCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCHHHHHEECCHHHHHHHHHHHHHHHHHHH
FRRIQSGAEFEPEMLAQTGTAALIVRMMRLPQGGVQLLLQGQARIKVQRWVTVKPYPQAH
HHHHHCCCCCCHHHHHHCCHHHHHHHHHHCCCCCHHEEECCCCEEEEEEEEEECCCCCCE
VTVALDPVDVSMETTGLARAVLAGFQQIVEQSPNLPDELAIAAANAPHPGMLADLIAANL
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHCC
NLNLDDQQKVLDTFDVHERLQLVLRLLEREREILLIGRKAQEEVSKNQREYVLRQQLEAI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
KRELGETDDHAAEIAELRRRIEEANLPAEARQEAERELLRLERMPPGAAEYTVARTYLDW
HHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LLDLPWHTSTEDNLDITQARQVLDEDHYDLERIKERIIEYLAVRKLRREEGADNEARGPI
HHCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
LCFVGPPGVGKTSLGASIARALGRKFVRVALGGVRDEAEIRGHRRTYIGALPGRIIQGLS
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCHHHHHHHHH
RAKSNNPVLLLDEVDKLSIGFQGDPAAALLEVLDPEQNVAFVDRYLDVPFDLSKVLFVCT
HCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHEEE
ANRADTIPPALLDRMELLELAGYTEQEKLEIARRYLIPRQRREQGMTNRGPELTTAALQR
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHH
LIREYTHEAGVRDLERRIGAIYRKMATRLASEQTLPDQVDAADLDDLLGPPRFRSETILG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCC
DNEVGVVTGLAWTPTGGDVLFVEVSVIPGNGQLILTGQLGDVMKESARAALTYARSRASA
CCCCEEEEEEEECCCCCCEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LGIDPEVFQKSDIHIHVPAGAVPKDGPSAGITIASALISALTRREVDKRIAMTGEVTLRG
CCCCHHHHCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECEEEEEE
KVLPIGGVKEKLLAAQRAGVRKVLLPTENEIDLRDVPAETKEQLEIVLVKHMDEVLHELG
EEEECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
LEIAPQPVSE
CEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA