BacMap

Definition	Chloroflexus sp. Y-400-fl chromosome, complete genome.
Accession	NC_012032
Length	5,268,950

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The map label for this gene is ppiB [H]

Identifier: 222523557

GI number: 222523557

Start: 316233

End: 316982

Strand: Direct

Name: ppiB [H]

Synonym: Chy400_0263

Alternate gene names: 222523557

Gene position: 316233-316982 (Clockwise)

Preceding gene: 222523556

Following gene: 222523558

Centisome position: 6.0

GC content: 56.4

Gene sequence:

>750_bases
GTGAGTAACGAGCGACCATCTACAACATCAAACCCGCTGGCCGGTCTTGTTGCTATTGCCATTTTGCTCATTGTGTTAGG
GTTTGTGGCCGGCCTCTTGATTAGCCGATCTGGAACACCAATAGTCGTACCAACCGCAGCACCTGCTCCTACCAACCCAC
CAGCACCAACAGAGCCTGCATCGGTTCCCACACCGATCACCGGCAGTATGCCCATACTGCCTACAGCCACCACCTATCAG
TACAGCAGTCCACCGCCAATGAGCATTGATCCGGCTAAAAAGTATACCGCTACTATCTACACCCCACGCGGTGAGATTGT
GATTGAACTGCTACCCGATATTGCGCCCCAGACGGTGAACAACTTCGTCTTCCTGGCCCGCCAGAACTTCTACAATGGCC
TGACCTGGCATCGGGTACTGCCCAACTTTATGGCTCAGGGTGGCGACCCACGCGGCGATGGCACCGGTGGCCCCGGCTAT
ACCATCCCGGCAGAGTTCACCGACAAGATTTTGTTCGACCAACCCGGTATCGTAGCTATGGCACGCTCGTCGGACCCAAA
CAGTGCCGGTTCGCAATTCTTCATCACCACGGCGCCGGCACCCCGGCTGAACGAGCAGTACACGATCTTCGGCAGAGTTA
TTCAGGGTCAGGAGATTGTTGACGGGATACCGCTGCGCGACCCGAGCAATCCTGCCGATCTGGCGACCCCCGGCGAGATG
ATTCTGGGTATTGCCATTAACGAAGAGTAG

Upstream 100 bases:

>100_bases
AGCTTTTATGAGACAACTGCCAGAAGAGCGGCGTATACGCACATCCTTGCGCGGTTTGATATAATGCCAGCGGAAAAATA
TCATACTACCGAGGTGATCT

Downstream 100 bases:

>100_bases
TTCAATATCTTTGTATTTTAAATGAGGAATGGCAACGTCATAGTGTTGCCATTCCTCATCACATTGTGGCACGTTGGGCG
TAGAAGTCTTCCTCTTCCAC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPASVPTPITGSMPILPTATTYQ
YSSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVNNFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGY
TIPAEFTDKILFDQPGIVAMARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEM
ILGIAINEE

Sequences:

>Translated_249_residues
MSNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPASVPTPITGSMPILPTATTYQ
YSSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVNNFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGY
TIPAEFTDKILFDQPGIVAMARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEM
ILGIAINEE
>Mature_248_residues
SNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPASVPTPITGSMPILPTATTYQY
SSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVNNFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGYT
IPAEFTDKILFDQPGIVAMARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEMI
LGIAINEE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=131, Percent_Identity=42.7480916030534, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI19557636, Length=129, Percent_Identity=41.0852713178295, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI7706339, Length=144, Percent_Identity=43.0555555555556, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI64276486, Length=118, Percent_Identity=41.5254237288136, Blast_Score=97, Evalue=9e-21,
Organism=Homo sapiens, GI4758950, Length=154, Percent_Identity=38.3116883116883, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI5031987, Length=130, Percent_Identity=41.5384615384615, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI10863927, Length=131, Percent_Identity=40.4580152671756, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4505991, Length=130, Percent_Identity=43.0769230769231, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4826932, Length=161, Percent_Identity=34.7826086956522, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22547215, Length=132, Percent_Identity=40.1515151515151, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI5454154, Length=154, Percent_Identity=35.7142857142857, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI22547212, Length=132, Percent_Identity=40.1515151515151, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI7657473, Length=132, Percent_Identity=40.1515151515151, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI42560244, Length=139, Percent_Identity=38.1294964028777, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI6631100, Length=138, Percent_Identity=39.1304347826087, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI45439316, Length=135, Percent_Identity=34.8148148148148, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI310110104, Length=146, Percent_Identity=34.9315068493151, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI5174637, Length=152, Percent_Identity=32.8947368421053, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI169163387, Length=129, Percent_Identity=35.6589147286822, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI310129267, Length=131, Percent_Identity=36.6412213740458, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310120620, Length=131, Percent_Identity=36.6412213740458, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI303305009, Length=131, Percent_Identity=35.1145038167939, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI169164185, Length=129, Percent_Identity=35.6589147286822, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI169163623, Length=129, Percent_Identity=35.6589147286822, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI310127646, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI310114371, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI310119221, Length=129, Percent_Identity=34.8837209302326, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=39.84375, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=39.84375, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=39.84375, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI209417936, Length=131, Percent_Identity=38.1679389312977, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI30102944, Length=131, Percent_Identity=38.1679389312977, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI219842199, Length=131, Percent_Identity=38.1679389312977, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI239751853, Length=136, Percent_Identity=34.5588235294118, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI113428306, Length=136, Percent_Identity=34.5588235294118, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI169214050, Length=136, Percent_Identity=34.5588235294118, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI178057341, Length=131, Percent_Identity=38.1679389312977, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI150418007, Length=129, Percent_Identity=35.6589147286822, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789763, Length=139, Percent_Identity=37.410071942446, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1786736, Length=139, Percent_Identity=37.410071942446, Blast_Score=81, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=130, Percent_Identity=45.3846153846154, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17539496, Length=133, Percent_Identity=42.1052631578947, Blast_Score=110, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=40.1515151515151, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=40.1515151515151, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=122, Percent_Identity=42.6229508196721, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17552780, Length=127, Percent_Identity=44.0944881889764, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17532641, Length=178, Percent_Identity=30.3370786516854, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17552782, Length=157, Percent_Identity=36.3057324840764, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17559074, Length=136, Percent_Identity=38.2352941176471, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17566266, Length=137, Percent_Identity=39.4160583941606, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539498, Length=149, Percent_Identity=38.255033557047, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17552784, Length=161, Percent_Identity=36.0248447204969, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17506307, Length=151, Percent_Identity=39.0728476821192, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17551284, Length=160, Percent_Identity=36.875, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17551282, Length=160, Percent_Identity=36.875, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=191, Percent_Identity=31.413612565445, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17532643, Length=139, Percent_Identity=39.568345323741, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=136, Percent_Identity=33.8235294117647, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320359, Length=151, Percent_Identity=41.7218543046358, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323246, Length=135, Percent_Identity=39.2592592592593, Blast_Score=90, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323562, Length=130, Percent_Identity=38.4615384615385, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321848, Length=154, Percent_Identity=40.2597402597403, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320510, Length=130, Percent_Identity=40.7692307692308, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322492, Length=173, Percent_Identity=33.5260115606936, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17986117, Length=135, Percent_Identity=43.7037037037037, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357249, Length=132, Percent_Identity=39.3939393939394, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=36.8794326241135, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24650807, Length=159, Percent_Identity=39.622641509434, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45549139, Length=153, Percent_Identity=37.9084967320261, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19922376, Length=128, Percent_Identity=36.71875, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922912, Length=128, Percent_Identity=43.75, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647301, Length=192, Percent_Identity=32.2916666666667, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=38.28125, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=38.28125, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586038, Length=159, Percent_Identity=35.8490566037736, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130249, Length=127, Percent_Identity=38.5826771653543, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24661775, Length=169, Percent_Identity=31.3609467455621, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355237, Length=169, Percent_Identity=31.3609467455621, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24661771, Length=169, Percent_Identity=31.3609467455621, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26322; Mature: 26191

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCC
SVPTPITGSMPILPTATTYQYSSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVN
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHH
NFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGYTIPAEFTDKILFDQPGIVAM
HEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHCCEEECCCCEEEE
ARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEM
EECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCE
ILGIAINEE
EEEEEECCC
>Mature Secondary Structure 
SNERPSTTSNPLAGLVAIAILLIVLGFVAGLLISRSGTPIVVPTAAPAPTNPPAPTEPA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCC
SVPTPITGSMPILPTATTYQYSSPPPMSIDPAKKYTATIYTPRGEIVIELLPDIAPQTVN
CCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCCHHHHH
NFVFLARQNFYNGLTWHRVLPNFMAQGGDPRGDGTGGPGYTIPAEFTDKILFDQPGIVAM
HEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEECHHHHCCEEECCCCEEEE
ARSSDPNSAGSQFFITTAPAPRLNEQYTIFGRVIQGQEIVDGIPLRDPSNPADLATPGEM
EECCCCCCCCCEEEEEECCCCCCCCCEEEEEEEECCCHHHCCCCCCCCCCCCCCCCCCCE
ILGIAINEE
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]