Click here to switch to the map view.

The map label for this gene is ilvC

Identifier: 222523471

GI number: 222523471

Start: 204104

End: 205126

Strand: Direct

Name: ilvC

Synonym: Chy400_0177

Alternate gene names: 222523471

Gene position: 204104-205126 (Clockwise)

Preceding gene: 222523470

Following gene: 222523472

Centisome position: 3.87

GC content: 59.63

Gene sequence:

>1023_bases
ATGGCAGAACTGTACTACGACAATCAGGCCGATCTCAACCGCTTGAAGAACAAGCCGATTGCCATCATCGGCTTCGGCAG
CCAGGGTCACGCCCATGCCCGTAACCTCGCCGACAGCGGCCTCGATGTGCGCGTCGGTCTTTACCCCGGCTCGAAGAGCT
GGGCCAAGGTCGAAGCTGCCGGGTTGAAAGTGATGACGGTAGCCGAGGCTGCCCGCGAAGCGCAGATCGTGATGATCCTG
ACCCCTGACATCGGCCAGGCCGACCTCTACCGCGAGCATATTGCACCGGCAATGGAACCCGGTAAAACGCTTATGTTCGC
GCACGGGTTCAATATTCGCTTTGGTCAGATCATCCCGCCCCAGGGTATCGATGTCAGCATGGTCGCGCCGAAAGCGCCCG
GTCATCGAGTACGCGAGGTCTTCGTGCAGGGTGGTGGCGTTCCGGCACTGATTGCGGTTGAGCAAGATGCGACTGGAGGA
GCATTTGAAGATGCGCTCGCCTACGCCAAAGGACTTGGCTGCACCCGTGCCGGGGTGTTGCGCACAACCTTTGCCGAAGA
GACCGAGACCGACCTCTTCGGCGAACAGGTTGTCTTGTGCGGTGGCGTGAGTGCGCTGGTCAAGGCCGCCTTCGAGACCC
TGGTCGAGGCCGGCTATCAGCCAGAAGTTGCCTACTTCGAGTGTATGCACGAGCTGAAGCTGATCGTTGACCTCTTCTAC
CAGGGTGGTCTCAACTACATGCGCTACTCGGTCAGCGATACCGCTGAGTGGGGCGATTACACAGCGGGGCCGAAGATCAT
TACCGATCAGACCCGTGCCGCTATGCGCCAGATTCTGGCCGACATCCAGAGCGGTGCCTTTGCCGAAGACTGGATCGATG
AGAATCACAATGGCCGACCGCGCTTCAACGCCTACCGACAGGCTGATATTAACCATCCGATTGAGCAGATTGGTCGTGAG
CTGCGCCGCATGATGCCTTTCGTCAACCCGCGCGAAGTCAAGCCGGGTGAAGGTGGCGCCTGA

Upstream 100 bases:

>100_bases
TAATCGTTAGCTACTGAGACGCCCGCTTTGGGCGTCTCAGTGGTTCTTACATCGTGCGCGATGCAGCGGGCATCGCATGA
GAGTGAGGAATTAGAGAATC

Downstream 100 bases:

>100_bases
GAGTAGATTGCATAGATCGTGGCCGGTAGTTGCTCCGGCCACGACACACCACCACATCACAGGAGGTACCCATGAGCAAC
ACGACTGAACCGAGTGTAGA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAAGLKVMTVAEAAREAQIVMIL
TPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPPQGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGG
AFEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFY
QGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRPRFNAYRQADINHPIEQIGRE
LRRMMPFVNPREVKPGEGGA

Sequences:

>Translated_340_residues
MAELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAAGLKVMTVAEAAREAQIVMIL
TPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPPQGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGG
AFEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFY
QGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRPRFNAYRQADINHPIEQIGRE
LRRMMPFVNPREVKPGEGGA
>Mature_339_residues
AELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAAGLKVMTVAEAAREAQIVMILT
PDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPPQGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGA
FEDALAYAKGLGCTRAGVLRTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFYQ
GGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRPRFNAYRQADINHPIEQIGREL
RRMMPFVNPREVKPGEGGA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=305, Percent_Identity=35.4098360655738, Blast_Score=149, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=325, Percent_Identity=32.6153846153846, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CHLAA (A9WC26)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001633808.1
- ProteinModelPortal:   A9WC26
- SMR:   A9WC26
- GeneID:   5824739
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0165
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37087; Mature: 36955

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAA
CCCEEECCHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHC
GLKVMTVAEAAREAQIVMILTPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPP
CEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCC
QGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGAFEDALAYAKGLGCTRAGVL
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
RTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFY
HHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRP
HCCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
RFNAYRQADINHPIEQIGRELRRMMPFVNPREVKPGEGGA
CCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AELYYDNQADLNRLKNKPIAIIGFGSQGHAHARNLADSGLDVRVGLYPGSKSWAKVEAA
CCEEECCHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHC
GLKVMTVAEAAREAQIVMILTPDIGQADLYREHIAPAMEPGKTLMFAHGFNIRFGQIIPP
CEEEEHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCC
QGIDVSMVAPKAPGHRVREVFVQGGGVPALIAVEQDATGGAFEDALAYAKGLGCTRAGVL
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHH
RTTFAEETETDLFGEQVVLCGGVSALVKAAFETLVEAGYQPEVAYFECMHELKLIVDLFY
HHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QGGLNYMRYSVSDTAEWGDYTAGPKIITDQTRAAMRQILADIQSGAFAEDWIDENHNGRP
HCCCCCEEEECCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCC
RFNAYRQADINHPIEQIGRELRRMMPFVNPREVKPGEGGA
CCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA