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The map label for this gene is mmsB [H]

Identifier: 222109190

GI number: 222109190

Start: 77770

End: 78636

Strand: Reverse

Name: mmsB [H]

Synonym: Avi_9609

Alternate gene names: 222109190

Gene position: 78636-77770 (Counterclockwise)

Preceding gene: 222109191

Following gene: 222109189

Centisome position: 60.29

GC content: 54.56

Gene sequence:

>867_bases
TTGACGGAACGTCCGAGAATTGGATTGGTCGGCGTCGGAAAAATGGGCCGGGCACTTGCGACACGCTTGTTGTCTTGTGG
CGTTGAGGTATTCGGTTGCGATCCCGCAGCCCAGAATCCACCGGACGGCTTGCAGTTTGTCGCAACGCCACGGCAACTGG
CTGACTGCTGCGATGTGGTCATGGGCTGCGTGAGCGGACAAGAGGCATTTCGCGAGGTCACTCTTGGCCCCAATGGAATT
CGAGGCGGCACGCGCGTTCATACCTATGCTAATGTTGGAACAACTGGCCCTTCATTGGTCAAGGAGATTGCACACGGACT
AGCGGAAGTTGACATCCGCACTATTGATGTGCCGATGACAGGAGGCCCTCGCCGCGCGGCAAGAGGTGAGGTCACCGTCA
TCGCAAGTGGCCCTCTTAAAGTGCTCCAAGCGGTCAGTCCGACCCTTGAAAAGTACAGCTCCAAAATCGTTTACGTCGGC
CCGGGCGTCGGTCAGGCACAATATGTTAAGGTGATCAACAACCTCGTGACCGCTGGAAACCTCGCAGTCGCCATTGAGGC
TTTAACGCTGGCAAAGAAGGCGACAATCTCGCGAGAGCTATTGCTCGAAGTGATCAACTCGGGATCTGCAGCAAGCGACG
TCAGTACTTCCAAAATCCCCTCCCATGTTCTGACGCGAACATTTGATTTTGGGGCCTCACTTGCCTTGGTTGATCATGAT
CTATCATGTTGTCTCCACGAGGCACGGTTAATTGATTGCGAAATGCGCGTCTCCAAGGCCGTCCTCGATGTTTATCGGAG
CGCGATTGAGGCTGGGAGTGCTCTCGACGATATTACGACGTTAGCTGTTTATTTGGAGAACCGATAG

Upstream 100 bases:

>100_bases
CGCGAGCTTTAAGCCCGCGGCATGTATTTTTTTGTATCAAGGGCTATTGTAAGCCAAATCTCCGGTCGGCCCTCTAAACG
GCGAAGTGAAAATGACAGGA

Downstream 100 bases:

>100_bases
GTTTGTCTGCTGCAGGCGCCGTGAAATGAATTGACGCGCCTAGAGGATCCCTGCGGTAACGACGGCGTGCAATCGTGAAA
CCAAGAGCCGGAGGTAACAT

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTERPRIGLVGVGKMGRALATRLLSCGVEVFGCDPAAQNPPDGLQFVATPRQLADCCDVVMGCVSGQEAFREVTLGPNGI
RGGTRVHTYANVGTTGPSLVKEIAHGLAEVDIRTIDVPMTGGPRRAARGEVTVIASGPLKVLQAVSPTLEKYSSKIVYVG
PGVGQAQYVKVINNLVTAGNLAVAIEALTLAKKATISRELLLEVINSGSAASDVSTSKIPSHVLTRTFDFGASLALVDHD
LSCCLHEARLIDCEMRVSKAVLDVYRSAIEAGSALDDITTLAVYLENR

Sequences:

>Translated_288_residues
MTERPRIGLVGVGKMGRALATRLLSCGVEVFGCDPAAQNPPDGLQFVATPRQLADCCDVVMGCVSGQEAFREVTLGPNGI
RGGTRVHTYANVGTTGPSLVKEIAHGLAEVDIRTIDVPMTGGPRRAARGEVTVIASGPLKVLQAVSPTLEKYSSKIVYVG
PGVGQAQYVKVINNLVTAGNLAVAIEALTLAKKATISRELLLEVINSGSAASDVSTSKIPSHVLTRTFDFGASLALVDHD
LSCCLHEARLIDCEMRVSKAVLDVYRSAIEAGSALDDITTLAVYLENR
>Mature_287_residues
TERPRIGLVGVGKMGRALATRLLSCGVEVFGCDPAAQNPPDGLQFVATPRQLADCCDVVMGCVSGQEAFREVTLGPNGIR
GGTRVHTYANVGTTGPSLVKEIAHGLAEVDIRTIDVPMTGGPRRAARGEVTVIASGPLKVLQAVSPTLEKYSSKIVYVGP
GVGQAQYVKVINNLVTAGNLAVAIEALTLAKKATISRELLLEVINSGSAASDVSTSKIPSHVLTRTFDFGASLALVDHDL
SCCLHEARLIDCEMRVSKAVLDVYRSAIEAGSALDDITTLAVYLENR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=287, Percent_Identity=26.1324041811847, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=23.3676975945017, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI145693186, Length=287, Percent_Identity=27.1777003484321, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1786719, Length=276, Percent_Identity=26.8115942028986, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1789092, Length=278, Percent_Identity=25.1798561151079, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790315, Length=280, Percent_Identity=23.5714285714286, Blast_Score=68, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=26.8707482993197, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=26.8707482993197, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574115, Length=291, Percent_Identity=22.3367697594502, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30284; Mature: 30153

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERPRIGLVGVGKMGRALATRLLSCGVEVFGCDPAAQNPPDGLQFVATPRQLADCCDVV
CCCCCCCCEEECCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEECHHHHHHHHHHH
MGCVSGQEAFREVTLGPNGIRGGTRVHTYANVGTTGPSLVKEIAHGLAEVDIRTIDVPMT
HHHHCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECC
GGPRRAARGEVTVIASGPLKVLQAVSPTLEKYSSKIVYVGPGVGQAQYVKVINNLVTAGN
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCC
LAVAIEALTLAKKATISRELLLEVINSGSAASDVSTSKIPSHVLTRTFDFGASLALVDHD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHCCCCEEEEEHHH
LSCCLHEARLIDCEMRVSKAVLDVYRSAIEAGSALDDITTLAVYLENR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECC
>Mature Secondary Structure 
TERPRIGLVGVGKMGRALATRLLSCGVEVFGCDPAAQNPPDGLQFVATPRQLADCCDVV
CCCCCCCEEECCHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEECHHHHHHHHHHH
MGCVSGQEAFREVTLGPNGIRGGTRVHTYANVGTTGPSLVKEIAHGLAEVDIRTIDVPMT
HHHHCCHHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEECC
GGPRRAARGEVTVIASGPLKVLQAVSPTLEKYSSKIVYVGPGVGQAQYVKVINNLVTAGN
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCC
LAVAIEALTLAKKATISRELLLEVINSGSAASDVSTSKIPSHVLTRTFDFGASLALVDHD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHCCCCEEEEEHHH
LSCCLHEARLIDCEMRVSKAVLDVYRSAIEAGSALDDITTLAVYLENR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]