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The map label for this gene is hisC [H]

Identifier: 222109188

GI number: 222109188

Start: 75240

End: 76346

Strand: Reverse

Name: hisC [H]

Synonym: Avi_9607

Alternate gene names: 222109188

Gene position: 76346-75240 (Counterclockwise)

Preceding gene: 222109189

Following gene: 222109187

Centisome position: 58.53

GC content: 50.59

Gene sequence:

>1107_bases
ATGAGCAATTCATGCCAACTCGTTTTTCCATCTCACATTGAAAGGTTGCCGCGTTATAGGCCAGCAGCAGATTTAGCTGT
AGTCTCCGAGACCTCAGCTGAACCTTTGGTCAACCTGGCATCAAACGAAAATCCTTATGGTACGAACCCGGGGTTTGCTG
ATGCCTTAAATGAAATCACGCGTTTTAACCTCGCGGAGTACCCTGACCCCGATGCGCTCCGTCTGAAGACCGCTATCGCG
GCGAAAAACCATGTTTCGATCGATCAGCTAATTATCGCGAACGGCTCCGATGAACTAATTGACTTGTCAGCTCGGACGCT
GCTGGCGCCAGGAACGAACGCGATCTTCGATGAGTATTCCTTTGTAGCCTATCGTAAGGCGACTTACCTCGCAGGAGCTA
CCGGTGTCAGTGTCCGACCTTCAGGCTGGAATGCAGATCTCAATGAGATGCTTCGTGTCATTGACACCAATACTCGGATG
ATATTTTTAGCAAATCCGAGCAATCCGACTCCAGGTTTTATTTCAACGGCAGAATTTGACAGCTTCATCAGCAGGGTTCC
TGCTACCGTCCTTGTAGTGCTCGATGAAGCCTATATCGATTTTGTTGAGCCGAACGAGCGGATCGATTGTAAGCTGCTGC
TCCAATCAAGAAGCAATGTCTTTATAACGCGCACCTTCTCCAAGGCATACGGACTTGCAGGTGTGCGGGTCGGCTATGGC
ATCGGTTCGCCGACACTTATTAACATGATGAACAGGATCAGGCAGCCCTTCTCCGTTGGCGTGTTGCCACAACTGGCCGC
GGTAAACGCGCTGGCCAATGAAGGCTTCGTGAACGAAACTAGAGCAAAAAACATCGAGCAGAAGGCCAGACTATCAGAAG
GATTGAGCGACCTTGGAATTGAGCACGCGGCATCCAAAGGAAATTTCATCATTGTAAAGTTGCGTGCTCCATCAGCAGCG
CACGAGGCGCTGCAGGCGAAGCGAATCCTTGTGCGCCGCTTGGCTTCCTATGGCCTGAGCGACTGGCTGCGTTTGACAAT
TGGCACAGAATCTCAAAACCGGATTGTACTTGACGCATTTCGAACCCTGACACAACAAGCAAACTGA

Upstream 100 bases:

>100_bases
CCGCCGCCGCGAAGGATCACCTTAGGATCTCTCGATGAACAAACCTCACGTTAGCACTGATCACACGACGTTTCATATCA
CATGAGGGTTAGGGTTTGAT

Downstream 100 bases:

>100_bases
GAGTCATGGTTGTGACTGCTACTATGCGTCTGAGTATCTAGAAGTGAGGGTCCCTCGTGAAAAGACTATTTTGGCTCCAC
ATCAAAAAGAGCGGAGGAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MSNSCQLVFPSHIERLPRYRPAADLAVVSETSAEPLVNLASNENPYGTNPGFADALNEITRFNLAEYPDPDALRLKTAIA
AKNHVSIDQLIIANGSDELIDLSARTLLAPGTNAIFDEYSFVAYRKATYLAGATGVSVRPSGWNADLNEMLRVIDTNTRM
IFLANPSNPTPGFISTAEFDSFISRVPATVLVVLDEAYIDFVEPNERIDCKLLLQSRSNVFITRTFSKAYGLAGVRVGYG
IGSPTLINMMNRIRQPFSVGVLPQLAAVNALANEGFVNETRAKNIEQKARLSEGLSDLGIEHAASKGNFIIVKLRAPSAA
HEALQAKRILVRRLASYGLSDWLRLTIGTESQNRIVLDAFRTLTQQAN

Sequences:

>Translated_368_residues
MSNSCQLVFPSHIERLPRYRPAADLAVVSETSAEPLVNLASNENPYGTNPGFADALNEITRFNLAEYPDPDALRLKTAIA
AKNHVSIDQLIIANGSDELIDLSARTLLAPGTNAIFDEYSFVAYRKATYLAGATGVSVRPSGWNADLNEMLRVIDTNTRM
IFLANPSNPTPGFISTAEFDSFISRVPATVLVVLDEAYIDFVEPNERIDCKLLLQSRSNVFITRTFSKAYGLAGVRVGYG
IGSPTLINMMNRIRQPFSVGVLPQLAAVNALANEGFVNETRAKNIEQKARLSEGLSDLGIEHAASKGNFIIVKLRAPSAA
HEALQAKRILVRRLASYGLSDWLRLTIGTESQNRIVLDAFRTLTQQAN
>Mature_367_residues
SNSCQLVFPSHIERLPRYRPAADLAVVSETSAEPLVNLASNENPYGTNPGFADALNEITRFNLAEYPDPDALRLKTAIAA
KNHVSIDQLIIANGSDELIDLSARTLLAPGTNAIFDEYSFVAYRKATYLAGATGVSVRPSGWNADLNEMLRVIDTNTRMI
FLANPSNPTPGFISTAEFDSFISRVPATVLVVLDEAYIDFVEPNERIDCKLLLQSRSNVFITRTFSKAYGLAGVRVGYGI
GSPTLINMMNRIRQPFSVGVLPQLAAVNALANEGFVNETRAKNIEQKARLSEGLSDLGIEHAASKGNFIIVKLRAPSAAH
EALQAKRILVRRLASYGLSDWLRLTIGTESQNRIVLDAFRTLTQQAN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=329, Percent_Identity=28.2674772036474, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1788722, Length=348, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=27.3972602739726, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40256; Mature: 40125

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSCQLVFPSHIERLPRYRPAADLAVVSETSAEPLVNLASNENPYGTNPGFADALNEIT
CCCCCEEECHHHHHHCCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
RFNLAEYPDPDALRLKTAIAAKNHVSIDQLIIANGSDELIDLSARTLLAPGTNAIFDEYS
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCEEECCCCCHHHHCHH
FVAYRKATYLAGATGVSVRPSGWNADLNEMLRVIDTNTRMIFLANPSNPTPGFISTAEFD
HHHHHHHHHEECCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHH
SFISRVPATVLVVLDEAYIDFVEPNERIDCKLLLQSRSNVFITRTFSKAYGLAGVRVGYG
HHHHHCCCEEEEEEEHHHHEECCCCCCCCEEEEEECCCCEEEEEEHHHHHCCCCEEEECC
IGSPTLINMMNRIRQPFSVGVLPQLAAVNALANEGFVNETRAKNIEQKARLSEGLSDLGI
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHCH
EHAASKGNFIIVKLRAPSAAHEALQAKRILVRRLASYGLSDWLRLTIGTESQNRIVLDAF
HHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
RTLTQQAN
HHHHHCCC
>Mature Secondary Structure 
SNSCQLVFPSHIERLPRYRPAADLAVVSETSAEPLVNLASNENPYGTNPGFADALNEIT
CCCCEEECHHHHHHCCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCHHHHHHHHH
RFNLAEYPDPDALRLKTAIAAKNHVSIDQLIIANGSDELIDLSARTLLAPGTNAIFDEYS
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCEEEECCCEEECCCCCHHHHCHH
FVAYRKATYLAGATGVSVRPSGWNADLNEMLRVIDTNTRMIFLANPSNPTPGFISTAEFD
HHHHHHHHHEECCCCCEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEHHHHH
SFISRVPATVLVVLDEAYIDFVEPNERIDCKLLLQSRSNVFITRTFSKAYGLAGVRVGYG
HHHHHCCCEEEEEEEHHHHEECCCCCCCCEEEEEECCCCEEEEEEHHHHHCCCCEEEECC
IGSPTLINMMNRIRQPFSVGVLPQLAAVNALANEGFVNETRAKNIEQKARLSEGLSDLGI
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHCH
EHAASKGNFIIVKLRAPSAAHEALQAKRILVRRLASYGLSDWLRLTIGTESQNRIVLDAF
HHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHH
RTLTQQAN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA