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The map label for this gene is gntP [C]

Identifier: 22127721

GI number: 22127721

Start: 4286984

End: 4288252

Strand: Reverse

Name: gntP [C]

Synonym: y3850

Alternate gene names: 22127721

Gene position: 4288252-4286984 (Counterclockwise)

Preceding gene: 22127722

Following gene: 22127720

Centisome position: 93.21

GC content: 54.37

Gene sequence:

>1269_bases
ATGACCACAGTTTCTGCTCTGGGCGCATTGGTGGCACTGATCGTGTCCATCGTCCTAATTTTACGCAAAGTGCCGCCTGC
TTACGGCATGATCGCGGGAGCGTTAGCGGGCGGCTTAGTCGGCGGTGCCGATCTGATTCAAACCATTAACCTCATGATTA
CGGGCGCTCAAGGCATCACGAACGCTGTGCTACGTATTCTTGCTGCCGGTATTCTGGCGGGCGTACTGATTGAGTCTGGT
GCGGCAAATACCATCGCCGAAACCATTGTACGAAAAGTCGGCGAAAAACGCGCCCTACTGGCACTGGCAGTTGCGACGAT
GCTGCTGACAGCGGTCGGGGTGTTTATCGATGTCGCGGTGATTACCGTTTCCCCAATCGCTCTGGCCATTGCGCACCGTG
CGGATATTTCCAAAATGGCCATCTTACTGGCGATGGTCGGCGGTGGCAAAGCGGGTAACGTGATGTCACCCAACCCGAAC
ACCATCGCCGCGGCAGACAGTTTTCATGTGCCGTTAACCTCACTGATGATTGCCGGTATTGTCCCCGGTTTGTTTGGCTT
GGCGTTGGCCTATTTTATGGCAAAACACCTAAAACATCGTGGTTCCAAAGTCGAAGCGCATGAGCTGGTAGTCAGTAAAA
ATGATACTGCGCTGCCTGCCTTTGGTGCAGCAATGGCGGCACCTCTGGTCGCCATCTTCCTACTGGCATTACGCCCTATA
GCTGGCATTGCCATTGACCCCCTGGTGGCTTTGCCGGTCGGCGGTTTAATTGGTGTCGTTGTCATGGGGCAATGGCGTCA
CACCAACCAATATATGGTTTCTGGCCTGTCACGTATGGCACCTGTGGCTATTATGCTATTAGGTACCGGTACATTGGCAG
GCATCATCGCCAACTCAGGTTTAAAAGATGTTTTGATTAGTGGCTTGAGCGCATCGGGTATGCCTTCTTATCTGCTGGCC
CCCATTTCAGGTGCACTGATGTCAATGGCGACCGCCTCAACCACGGCGGGCACCGCAGTCGCTTCTGCGGTATTTAGCTC
AACGCTTATCGGAATGGGTATCTCAGCGCTGGCCGGAGCCGCGATGGTCCACGCAGGTGCCACGGTGCTCGATCACATGC
CGCACGGCAGCTTCTTCCATGCCACTGGCGGTAGCGTCAACATGCAGGTACATGAACGCCTAAAACTGCTGCCCTATGAG
ACCGCCGTGGGTTTGATGATCGCCTTTGTCTCTACGCTGATGTTTGGCGTGTTTAATTTAGCGGGTTAA

Upstream 100 bases:

>100_bases
CCACCATAATGGCGACGTTGTTCTTGATCGCGACGTACCCTACTGCCGCACAGATCTTCCCCAAGCGGCCAAAATAGAAT
AATGAAAGCGGGAGTCATAT

Downstream 100 bases:

>100_bases
AGAGGTACGCATGAAAATTATTATTGCTCCCGATTCATTCAAAGAAAGCCTCACCGCCATGCAGGTTGCCGAGGCCATTG
AGCAAGGCTTCAGCGAGATT

Product: GntP family permease

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTTVSALGALVALIVSIVLILRKVPPAYGMIAGALAGGLVGGADLIQTINLMITGAQGITNAVLRILAAGILAGVLIESG
AANTIAETIVRKVGEKRALLALAVATMLLTAVGVFIDVAVITVSPIALAIAHRADISKMAILLAMVGGGKAGNVMSPNPN
TIAAADSFHVPLTSLMIAGIVPGLFGLALAYFMAKHLKHRGSKVEAHELVVSKNDTALPAFGAAMAAPLVAIFLLALRPI
AGIAIDPLVALPVGGLIGVVVMGQWRHTNQYMVSGLSRMAPVAIMLLGTGTLAGIIANSGLKDVLISGLSASGMPSYLLA
PISGALMSMATASTTAGTAVASAVFSSTLIGMGISALAGAAMVHAGATVLDHMPHGSFFHATGGSVNMQVHERLKLLPYE
TAVGLMIAFVSTLMFGVFNLAG

Sequences:

>Translated_422_residues
MTTVSALGALVALIVSIVLILRKVPPAYGMIAGALAGGLVGGADLIQTINLMITGAQGITNAVLRILAAGILAGVLIESG
AANTIAETIVRKVGEKRALLALAVATMLLTAVGVFIDVAVITVSPIALAIAHRADISKMAILLAMVGGGKAGNVMSPNPN
TIAAADSFHVPLTSLMIAGIVPGLFGLALAYFMAKHLKHRGSKVEAHELVVSKNDTALPAFGAAMAAPLVAIFLLALRPI
AGIAIDPLVALPVGGLIGVVVMGQWRHTNQYMVSGLSRMAPVAIMLLGTGTLAGIIANSGLKDVLISGLSASGMPSYLLA
PISGALMSMATASTTAGTAVASAVFSSTLIGMGISALAGAAMVHAGATVLDHMPHGSFFHATGGSVNMQVHERLKLLPYE
TAVGLMIAFVSTLMFGVFNLAG
>Mature_421_residues
TTVSALGALVALIVSIVLILRKVPPAYGMIAGALAGGLVGGADLIQTINLMITGAQGITNAVLRILAAGILAGVLIESGA
ANTIAETIVRKVGEKRALLALAVATMLLTAVGVFIDVAVITVSPIALAIAHRADISKMAILLAMVGGGKAGNVMSPNPNT
IAAADSFHVPLTSLMIAGIVPGLFGLALAYFMAKHLKHRGSKVEAHELVVSKNDTALPAFGAAMAAPLVAIFLLALRPIA
GIAIDPLVALPVGGLIGVVVMGQWRHTNQYMVSGLSRMAPVAIMLLGTGTLAGIIANSGLKDVLISGLSASGMPSYLLAP
ISGALMSMATASTTAGTAVASAVFSSTLIGMGISALAGAAMVHAGATVLDHMPHGSFFHATGGSVNMQVHERLKLLPYET
AVGLMIAFVSTLMFGVFNLAG

Specific function: High-Affinity Gluconate Transporter With Fairly Broad Specificity, Including Low Affinity For Glucuronate, Several Disaccharides, And Some Hexoses, But Not Glucose. [C]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Escherichia coli, GI1790776, Length=429, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789097, Length=153, Percent_Identity=33.9869281045752, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 42512; Mature: 42380

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVSALGALVALIVSIVLILRKVPPAYGMIAGALAGGLVGGADLIQTINLMITGAQGIT
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEECCHHHH
NAVLRILAAGILAGVLIESGAANTIAETIVRKVGEKRALLALAVATMLLTAVGVFIDVAV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
ITVSPIALAIAHRADISKMAILLAMVGGGKAGNVMSPNPNTIAAADSFHVPLTSLMIAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
VPGLFGLALAYFMAKHLKHRGSKVEAHELVVSKNDTALPAFGAAMAAPLVAIFLLALRPI
HHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGIAIDPLVALPVGGLIGVVVMGQWRHTNQYMVSGLSRMAPVAIMLLGTGTLAGIIANSG
CCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
LKDVLISGLSASGMPSYLLAPISGALMSMATASTTAGTAVASAVFSSTLIGMGISALAGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHH
AMVHAGATVLDHMPHGSFFHATGGSVNMQVHERLKLLPYETAVGLMIAFVSTLMFGVFNL
HHHHHCHHHHHCCCCCCEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
AG
CC
>Mature Secondary Structure 
TTVSALGALVALIVSIVLILRKVPPAYGMIAGALAGGLVGGADLIQTINLMITGAQGIT
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHEECCHHHH
NAVLRILAAGILAGVLIESGAANTIAETIVRKVGEKRALLALAVATMLLTAVGVFIDVAV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
ITVSPIALAIAHRADISKMAILLAMVGGGKAGNVMSPNPNTIAAADSFHVPLTSLMIAGI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHH
VPGLFGLALAYFMAKHLKHRGSKVEAHELVVSKNDTALPAFGAAMAAPLVAIFLLALRPI
HHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGIAIDPLVALPVGGLIGVVVMGQWRHTNQYMVSGLSRMAPVAIMLLGTGTLAGIIANSG
CCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
LKDVLISGLSASGMPSYLLAPISGALMSMATASTTAGTAVASAVFSSTLIGMGISALAGA
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHH
AMVHAGATVLDHMPHGSFFHATGGSVNMQVHERLKLLPYETAVGLMIAFVSTLMFGVFNL
HHHHHCHHHHHCCCCCCEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHC
AG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]