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The map label for this gene is apaH [H]

Identifier: 22127559

GI number: 22127559

Start: 4096046

End: 4096915

Strand: Direct

Name: apaH [H]

Synonym: y3685

Alternate gene names: 22127559

Gene position: 4096046-4096915 (Clockwise)

Preceding gene: 22127558

Following gene: 22127565

Centisome position: 89.03

GC content: 48.16

Gene sequence:

>870_bases
ATGTCTACTTATCTTATTGGTGATATTCATGGCTGCCTCGATGAATTACTTGCGCTTTTAGCCCAGGTGAATTTCGATCC
ACAGCAGGATACTTTATGGCTGACGGGCGATTTAGTTGCCCGTGGTCCCGCTTCATTGGATGTTTTACGTTATGTACGTT
CGTTAGGACCCGCAGTTCGTATGGTGCTGGGTAACCATGACCTGCATTTACTGGCAGTCTACGCGGGCATCAGCCGTAAT
AAACCAAAAGATCGTATTACCCCGCTGCTGGATGCACCCGATGCTGATGAGCTAATTAATTGGCTACGTCGCCAACCCGT
TTTGCAGGTTGATGACCAGCTTAAATTGATTATGGCCCACGCAGGCATCACACCACAGTGGGATATTGAAACGGCCAAAA
TGTGTGCGCGAGAAGTTGAAGCGGTATTGAGCAGCGATAGTTATCCGCTATTTTTGGATGCGATGTACGGTGATATGCCA
AACAACTGGTCACCAGAGCTTACCGGGCTGGCGCGTTTGCGCTTTAGTACCAATGCACTTACGCGGATGCGCTTTTGCTT
CCCGAATGGCCAACTTGATATGATCTGCAAAGACACGCCAGAAAACGCGCCAGCCCCTCTCAAACCTTGGTTTGACCTAC
CAAGGCTCGTTGACCCTGAATATTCAATTATTTTTGGTCATTGGGCATCATTGGAAGGTAAAGGTGTACCAGAGGGGATA
TATGGACTGGACACTGGCTGTTGCTGGGGAGGGGATTTAACCCTACTTCGTTGGGACGATAAACGTTATTTCACACAGCG
CGCTTTCAAAGCCGAGGCTGAAATTAATAATAACAATGGATTTGCAGCGGGCGAAGCAGTACAACACTAA

Upstream 100 bases:

>100_bases
TATGAAATGATTGATCACCTTGGACAGGCCTTCCGTACTGTAATTCCGGTATTCCGCTTAGCGATCCCAGCCCTGATCCA
CTAACCCTGACTCATTAACT

Downstream 100 bases:

>100_bases
TTGGTGTGATGCCAAATTAATCTTGTAAAGACGCTAATTAAAGACGCATGAGCTTATGCGTCTTTAGATTTCACCTATAA
TTAACAGCATCACTGTCTAT

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSTYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRN
KPKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAHAGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMP
NNWSPELTGLARLRFSTNALTRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGI
YGLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH

Sequences:

>Translated_289_residues
MSTYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRN
KPKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAHAGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMP
NNWSPELTGLARLRFSTNALTRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGI
YGLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH
>Mature_288_residues
STYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRNK
PKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAHAGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMPN
NWSPELTGLARLRFSTNALTRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGIY
GLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP [H]

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1786234, Length=266, Percent_Identity=80.0751879699248, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004617
- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.6.1.41 [H]

Molecular weight: Translated: 32341; Mature: 32210

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVR
CCCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHCHHHH
MVLGNHDLHLLAVYAGISRNKPKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAH
HHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCEECCCHHEEEEEC
AGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMPNNWSPELTGLARLRFSTNAL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHEEECCCHH
TRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGI
HEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
YGLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH
CCCCCCCEECCCEEEEEECCHHHHHHHHHHHHEEEECCCCEECCHHCCC
>Mature Secondary Structure 
STYLIGDIHGCLDELLALLAQVNFDPQQDTLWLTGDLVARGPASLDVLRYVRSLGPAVR
CCEEEEHHHHHHHHHHHHHHHCCCCCCCCEEEEECCEEECCCCHHHHHHHHHHHCHHHH
MVLGNHDLHLLAVYAGISRNKPKDRITPLLDAPDADELINWLRRQPVLQVDDQLKLIMAH
HHHCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCEECCCHHEEEEEC
AGITPQWDIETAKMCAREVEAVLSSDSYPLFLDAMYGDMPNNWSPELTGLARLRFSTNAL
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHEEECCCHH
TRMRFCFPNGQLDMICKDTPENAPAPLKPWFDLPRLVDPEYSIIFGHWASLEGKGVPEGI
HEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
YGLDTGCCWGGDLTLLRWDDKRYFTQRAFKAEAEINNNNGFAAGEAVQH
CCCCCCCEECCCEEEEEECCHHHHHHHHHHHHEEEECCCCEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA