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The map label for this gene is hemC [H]

Identifier: 221230780

GI number: 221230780

Start: 2896431

End: 2897387

Strand: Reverse

Name: hemC [H]

Synonym: MLBr_02421

Alternate gene names: 221230780

Gene position: 2897387-2896431 (Counterclockwise)

Preceding gene: 221230781

Following gene: 221230779

Centisome position: 88.66

GC content: 64.05

Gene sequence:

>957_bases
TTGGCCCACGTGATCCGGATAGGCACTCGGGGTAGCTTGTTAGCCACCACTCAGGCTGCGCTCGTTAGAGACGCTCTCAT
AGCCAACGGGCATCCTGCGGAGTTGGTGATCGTCAATACCGCGGGCGATCAGTCGTCTGCGTCTATCGACAGTCTAGGTG
TGGGCGTCTTCACCACCGCATTGCGTGCGGCTATCGAAGAGGGCTGCGTCGATGCTGCGGTGCACTCGTACAAGGATTTG
CCAACTGCTGACGATCCGCGGTTCACGGTAGCGGCGATTCCTCCACGAAATGACCCCCGCGACGCAGTGGTAACTCGCGA
TGAGCTGGTTCTTGCTGAATTGCCGGCTGGATCGCTGGTAGGCACGTCATCGCCGCGGCGGGCAGCTCAGCTTAGGGCAT
TGGGTCTCGGTTTGGAAATTCGCCCCCTACGAGGCAACCTAGATACCAGGTTGAACAGGGTAAGCAGTGGCGATCTTGAC
GCCATCGTGGTGGCCCGGGCCGGGTTGGCCCGGCTGGGCCGCCTCGATGAAGTCACCGAGACGTTAGATCCGGTGCAGAT
GGTGCCAGCACCGGCTCAAGGCGCGATCGCGGTCGAATGCCGCGCTGGTGACAGTCGGTTGGTGGCGGTGCTGGCGGCGT
TGGACGATGCCGACACACGTGCGGCGGTCACCGCGGAGCGAGTCCTGCTCGCCGAACTGGAGGCCGGCTGCTCCGCACCG
GTGGGCGCGATCGCTCAAGTGGTCGAGTCTATCGATGGGGAAGGCCGCGTCTTCGAAGAGTTGTCGTTGCGCGGCTGCGT
GGCGGCGTTGGACGGATCCGACGTGATCCGCGCGTCCGGCATCAGCACGTCCGGTCGGGCGAGCGAGCTTGGGCTAGCAG
TTGCCGTGGAGCTGTTTGAGCTGGGTGCCCGGGAGCTGATGTGGGGAGCGCGGTCAGACCGGGCGCGAGGAAGTTGA

Upstream 100 bases:

>100_bases
GCGGGTGAATTACCAGTGATGGTAAGTGGGTTCAGCGATACCACTAGGTACGGCACAAGCCCTGCCCAGAGCAGCTCAAA
ATATCACGCCGAGTAGTTGA

Downstream 100 bases:

>100_bases
ACGGGAGTGGTGGGAGCGACAATGACGACGCGAGGGCGTAAGCTTAGACCAGGTCGCATCACATTTGTGGGCGCCGGTCC
AGGAGCCCCAGGGTTACTAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAAIEEGCVDAAVHSYKDL
PTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLD
AIVVARAGLARLGRLDEVTETLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAP
VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGARELMWGARSDRARGS

Sequences:

>Translated_318_residues
MAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAAIEEGCVDAAVHSYKDL
PTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLD
AIVVARAGLARLGRLDEVTETLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAP
VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGARELMWGARSDRARGS
>Mature_317_residues
AHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTALRAAIEEGCVDAAVHSYKDLP
TADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLVGTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDA
IVVARAGLARLGRLDEVTETLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAPV
GAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFELGARELMWGARSDRARGS

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=288, Percent_Identity=40.625, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI20149500, Length=288, Percent_Identity=40.625, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI48994974, Length=312, Percent_Identity=42.3076923076923, Blast_Score=194, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6319996, Length=286, Percent_Identity=31.1188811188811, Blast_Score=122, Evalue=7e-29,
Organism=Drosophila melanogaster, GI20130425, Length=284, Percent_Identity=39.0845070422535, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32831; Mature: 32699

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA
CCEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCEE
GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEHHHHHHHHCCHHHHHH
TLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAP
HCCCHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE
HHHHHHHHHHCCCCCCCHHHHHHHHEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
LGARELMWGARSDRARGS
CCHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AHVIRIGTRGSLLATTQAALVRDALIANGHPAELVIVNTAGDQSSASIDSLGVGVFTTA
CEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LRAAIEEGCVDAAVHSYKDLPTADDPRFTVAAIPPRNDPRDAVVTRDELVLAELPAGSLV
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEECCCEEEEECCCCCEE
GTSSPRRAAQLRALGLGLEIRPLRGNLDTRLNRVSSGDLDAIVVARAGLARLGRLDEVTE
CCCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCCCEEEEHHHHHHHHCCHHHHHH
TLDPVQMVPAPAQGAIAVECRAGDSRLVAVLAALDDADTRAAVTAERVLLAELEAGCSAP
HCCCHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCC
VGAIAQVVESIDGEGRVFEELSLRGCVAALDGSDVIRASGISTSGRASELGLAVAVELFE
HHHHHHHHHHCCCCCCCHHHHHHHHEEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHH
LGARELMWGARSDRARGS
CCHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]