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The map label for this gene is hisA [H]

Identifier: 221230124

GI number: 221230124

Start: 1506056

End: 1506793

Strand: Direct

Name: hisA [H]

Synonym: MLBr_01261

Alternate gene names: 221230124

Gene position: 1506056-1506793 (Clockwise)

Preceding gene: 221230123

Following gene: 221230125

Centisome position: 46.08

GC content: 58.81

Gene sequence:

>738_bases
TTGATGTCGCTGATACTTTTACCGGCTGTCGACGTGGTCGAGGGGCGCGCCGTGCGCCTGGTTCAAGGAAAGGCCGGTAG
CGAAAACGATTACGGTTCAGCATTGGACGCCGCGTTGTGCTGGCAACGCGACGGCGCCGACTGGATTCACCTAGTGGATC
TGGACGCAGCGTTTGGTCGCGGTTCCAACCGCGAACTGCTTTCTGAGATGGTGGGCAAGCTTGATGTGCAGGTCGAGCTA
TCCGGAGGTATTCGTGACGACGACTCTTTGAATGCTGCGCTAGCTACCGGCTGTGCACGGGTCAACCTAGGTACGGCCGC
ATGTGAGAACCCGCACTGGTGCGCACAGGTGATTGCCGAGCACGGTGACAAGATCGCCGTCGGTTTGGACGTCCAGATCG
TCGACGGCCAGCATCGGCTGCGTGGACGCGGCTGGGAAACCGACGGAGGAGACCTGTGGGATGTGTTAGAAAATCTTGAT
AGACAAGGATGTTCACGGTTCATTGTTACCGATGTCACTAAGGACGGTACGTTGGACGGTCCCAACCTTGACCTGCTGGC
AAGTGTCTCCGATCGCACCAACGTCCCGGTGATCGCGTCCGGTGGCGTTTCCAGTCTGGATGACTTGCGTGCTATCGCTA
AATTCACCGAGCGCGGGATCGAGGGTGCTATTGTGGGCAAAGCCCTCTATGCCGAACGGTTCACCTTGCCGCAGGCACTG
GCCGTGGTGCGGATGTAG

Upstream 100 bases:

>100_bases
AGAAGGACCACTGGTTGCCACCCAGTTCCATCCGGAGAAGAGTGGGGACGCTGGAGCAACCTTGCTGAGCAATTGGCTTG
GGGAACTTTAAAGGATGCTG

Downstream 100 bases:

>100_bases
CCCCACAATGGATCTGTACGCGTTGATGGCCGAGGAGTCGGCAATCCTTGATGCTGCGAGTTCGTTCCTGGCTGGCCATC
GCACCGATCCGGCGGCCGGC

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVEL
SGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLD
RQGCSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQAL
AVVRM

Sequences:

>Translated_245_residues
MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVEL
SGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLD
RQGCSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQAL
AVVRM
>Mature_245_residues
MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGRGSNRELLSEMVGKLDVQVEL
SGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAEHGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLD
RQGCSRFIVTDVTKDGTLDGPNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQAL
AVVRM

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways [H]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=32.5102880658436, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788336, Length=246, Percent_Identity=22.3577235772358, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16; =5.3.1.24 [H]

Molecular weight: Translated: 26135; Mature: 26135

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGR
CCEEEEECCHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCHHHCC
GSNRELLSEMVGKLDVQVELSGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAE
CCCHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHCCCEEECCCCCCCCCHHHHHHHHH
HGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLDRQGCSRFIVTDVTKDGTLDG
CCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
PNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQAL
CCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHH
AVVRM
HHHCC
>Mature Secondary Structure
MMSLILLPAVDVVEGRAVRLVQGKAGSENDYGSALDAALCWQRDGADWIHLVDLDAAFGR
CCEEEEECCHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCHHHCC
GSNRELLSEMVGKLDVQVELSGGIRDDDSLNAALATGCARVNLGTAACENPHWCAQVIAE
CCCHHHHHHHHHCEEEEEEECCCCCCCCCCHHHHHHCCCEEECCCCCCCCCHHHHHHHHH
HGDKIAVGLDVQIVDGQHRLRGRGWETDGGDLWDVLENLDRQGCSRFIVTDVTKDGTLDG
CCCEEEEEEEEEEECCCHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
PNLDLLASVSDRTNVPVIASGGVSSLDDLRAIAKFTERGIEGAIVGKALYAERFTLPQAL
CCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHH
AVVRM
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]