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The map label for this gene is hisB

Identifier: 221230122

GI number: 221230122

Start: 1504797

End: 1505429

Strand: Direct

Name: hisB

Synonym: MLBr_01259

Alternate gene names: 221230122

Gene position: 1504797-1505429 (Clockwise)

Preceding gene: 221230121

Following gene: 221230123

Centisome position: 46.05

GC content: 57.82

Gene sequence:

>633_bases
GTGACCAACACCGAAGTAGGGAAAACAACGCGTCGTGCGCGTATTGAACGCCGCACCAGCGAATCTGATATCGTCGTTGA
ACTCGACCTGGACGGCACCGGGCAGGTTCACATCGATACCGGTGTCTCGTTCTATGACCATATGCTGACTGCGCTGGGCA
GCCACGCTAGTTTTGATCTGACCGTGTGTACCAAAGGCGACGTGGAGATCGAAGCCCATCACACCATCGAGGACACCGCG
ATTGCGCTGGGTCAGGCGTTTGGGCAGGCGCTGGGAAACAAGAAGGGCATCCGCAGGTTCGGAGACGCCTTCATCCCGAT
GGACGAGACCCTGGTACACGCGGTAGTCGATGTATCAGGTCGTCCTTATTGTGTGCACACCGGGGAACCTGATCACCTGC
AGCACAACATTATTTCCGGAAGTTCGGTGCCCTACTCCACCGTCATCAATCGGCACGTGTTCGAGTCGCTAGCGGCCAAT
GCCCGTATCGCGTTGCATGTGCGCGTCTTGTACGGGCGCGATCCGCATCACATCACTGAAGCGCAATACAAAGCCGTCGC
GCGCGCGTTAAGTGAGGCGGTCAAATTCGACCCTCGGTTTTCGGGCGTGCCGTCCACCAAAGGTGTCCTGTGA

Upstream 100 bases:

>100_bases
GCGCTACCACGGGTTTGGCCGAAGAGAACGACGCGTTCCTTAAAGCCAGCTCCGAGATAGCTGCCACCGAATTGGCCCCA
GCCACCACACTAGGAGCCTC

Downstream 100 bases:

>100_bases
GAAGTAAATCGGTTGTAGTTCTGGATTACGGTTCGGGTAATTTGTGGTCGGTGCAGCGCGCGCTGCAGCGGGTTGGTGCC
GCGGTCGAAGTTACGGCTGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFYDHMLTALGSHASFDLTVCTKGDVEIEAHHTIEDTA
IALGQAFGQALGNKKGIRRFGDAFIPMDETLVHAVVDVSGRPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAAN
ARIALHVRVLYGRDPHHITEAQYKAVARALSEAVKFDPRFSGVPSTKGVL

Sequences:

>Translated_210_residues
MTNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFYDHMLTALGSHASFDLTVCTKGDVEIEAHHTIEDTA
IALGQAFGQALGNKKGIRRFGDAFIPMDETLVHAVVDVSGRPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAAN
ARIALHVRVLYGRDPHHITEAQYKAVARALSEAVKFDPRFSGVPSTKGVL
>Mature_209_residues
TNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFYDHMLTALGSHASFDLTVCTKGDVEIEAHHTIEDTAI
ALGQAFGQALGNKKGIRRFGDAFIPMDETLVHAVVDVSGRPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAANA
RIALHVRVLYGRDPHHITEAQYKAVARALSEAVKFDPRFSGVPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=210, Percent_Identity=37.6190476190476, Blast_Score=141, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324776, Length=226, Percent_Identity=37.6106194690265, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_MYCLB (B8ZRB1)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503538.1
- ProteinModelPortal:   B8ZRB1
- SMR:   B8ZRB1
- EnsemblBacteria:   EBMYCT00000087544
- GeneID:   7324680
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000017533
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22925; Mature: 22794

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFYDHMLTALGSHASFDL
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEE
TVCTKGDVEIEAHHTIEDTAIALGQAFGQALGNKKGIRRFGDAFIPMDETLVHAVVDVSG
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCC
RPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAANARIALHVRVLYGRDPHHITE
CCEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
AQYKAVARALSEAVKFDPRFSGVPSTKGVL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TNTEVGKTTRRARIERRTSESDIVVELDLDGTGQVHIDTGVSFYDHMLTALGSHASFDL
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCCCEEE
TVCTKGDVEIEAHHTIEDTAIALGQAFGQALGNKKGIRRFGDAFIPMDETLVHAVVDVSG
EEEECCCEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCC
RPYCVHTGEPDHLQHNIISGSSVPYSTVINRHVFESLAANARIALHVRVLYGRDPHHITE
CCEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHH
AQYKAVARALSEAVKFDPRFSGVPSTKGVL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA