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The map label for this gene is nadA

Identifier: 221230101

GI number: 221230101

Start: 1446740

End: 1447798

Strand: Direct

Name: nadA

Synonym: MLBr_01225

Alternate gene names: 221230101

Gene position: 1446740-1447798 (Clockwise)

Preceding gene: 221230099

Following gene: 221230102

Centisome position: 44.27

GC content: 61.85

Gene sequence:

>1059_bases
GTGACGGTGCTGAATGGCATGGAGCCGCTCGCCGGCGACATGACTGTCGTGATTGCTGGCATTACCGATTCACCGGTCGG
CTACGCCGGCGTGGACGGTGACGAGCAGTGGGCTACTGAGATTCGTCGGTTGACGCGATTGCGTGGCGCCACTGTGCTTG
CGCACAACTATCAGTTGCCCGCCATCCAGGACATCGCTGACTACGTGGGGGACTCGCTGGCGCTGTCGCGGATCGCTGCC
GAGGTGCCCGAGGAGACTATCGTGTTCTGCGGTGTGCACTTTATGGCCGAGACAGCCAAGATCCTAAGCCCGAACAAGAC
CGTGCTCATCCCGGACCAGCGGGCGGGCTGTTCACTGGCCGATTCAATCACCCCCGACGAGCTGTGTGCCTGGAAAGACG
AGCACCCCGGCGCTGCTGTGGTGTCTTATGTCAACACCACGGCGGAAGTGAAGGCGCTCACCGATATCTGTTGCACCTCG
TCAAATGCAGTGGACGTCGTCGAGTCCATCGACCCCAGTCGCGAGGTGTTGTTCTGCCCAGACCAATTTCTGGGCGCTCA
TGTTCGTCGCGTGACCGGCCGCAAGAACGTGTATGTGTGGATGGGGGAATGCCACGTGCACGCCGGGATCAACGGCGACG
AGCTCGTTGATCAGGCTCGCGCAAATCCCGACGCCGAGCTCTTTGTACACCCGGAATGTGGTTGCTCGACCTCGGCGCTG
TACCTCGCTGGCGAAGGCGCGTTCCCGCCGGACCGAGTCAAGATCTTGTCCACTGGCGGCATGCTAACTGCCGCTAGGCA
GACGCAGTACCGCAAAATTTTGGTCGCCACTGAGGTCGGCATGTTGTATCAGCTGCGCCGGGCAGCACCGGAAATCGACT
TCCGCGCGGTCAACGACCGCGCGTCGTGCAAGTACATGAAGATGATCACCCCCGGTGCACTGTTGCGTTGTCTGGTCGAG
GGGACCGACGAGGTTCACGTCGACTCGGAAATCGCGGCGGCGGGCCGGCGCAGTGTGCAGCGTATGATCGAAATCGGGCT
GCCTGGCGGTGGCGAATGA

Upstream 100 bases:

>100_bases
GCGAACCTGGAACACGACAGCTAGCACTTCGTGTGCGGTGCTAGCATAGGCCATGTTTTCGATTATAAGTCGAAAACCTC
CTGTGCCGAAAGGAGCTGCC

Downstream 100 bases:

>100_bases
TGGCCGTTCCCGACTGGAAGCACGCGGCTGACGTGGTGGTAATAGGAACCGGCGTGGCGGGCTTGGCTGCCGCGCTTGCC
GCCCACCGCGCCGGTCGCAA

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLPAIQDIADYVGDSLALSRIAA
EVPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLADSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTS
SNAVDVVESIDPSREVLFCPDQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSAL
YLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDRASCKYMKMITPGALLRCLVE
GTDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE

Sequences:

>Translated_352_residues
MTVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLPAIQDIADYVGDSLALSRIAA
EVPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLADSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTS
SNAVDVVESIDPSREVLFCPDQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSAL
YLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDRASCKYMKMITPGALLRCLVE
GTDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE
>Mature_351_residues
TVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLPAIQDIADYVGDSLALSRIAAE
VPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLADSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTSS
NAVDVVESIDPSREVLFCPDQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSALY
LAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDRASCKYMKMITPGALLRCLVEG
TDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 2 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=333, Percent_Identity=33.033033033033, Blast_Score=168, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_MYCLB (B8ZR90)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503517.1
- ProteinModelPortal:   B8ZR90
- SMR:   B8ZR90
- EnsemblBacteria:   EBMYCT00000086888
- GeneID:   7327083
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000016402
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- GO:   GO:0005737
- HAMAP:   MF_00568
- InterPro:   IPR003473
- InterPro:   IPR023066
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 37919; Mature: 37787

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 72-72 BINDING 143-143 BINDING 160-160 BINDING 230-230 BINDING 258-258

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLP
CCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AIQDIADYVGDSLALSRIAAEVPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLA
HHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
DSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTSSNAVDVVESIDPSREVLFCP
CCCCHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECC
DQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSAL
HHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEE
YLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDR
EEECCCCCCCCCEEEEECCCEEEHHHHHHHHEEEEEHHHHHHHHHHHHCCCCCEEECCCC
ASCKYMKMITPGALLRCLVEGTDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE
CCCEEEEECCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TVLNGMEPLAGDMTVVIAGITDSPVGYAGVDGDEQWATEIRRLTRLRGATVLAHNYQLP
CCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCC
AIQDIADYVGDSLALSRIAAEVPEETIVFCGVHFMAETAKILSPNKTVLIPDQRAGCSLA
HHHHHHHHHCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEEECCCCCCCCCC
DSITPDELCAWKDEHPGAAVVSYVNTTAEVKALTDICCTSSNAVDVVESIDPSREVLFCP
CCCCHHHHHCCCCCCCCCEEEHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEECC
DQFLGAHVRRVTGRKNVYVWMGECHVHAGINGDELVDQARANPDAELFVHPECGCSTSAL
HHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHHHHHCCCCCEEEECCCCCCCCCEE
YLAGEGAFPPDRVKILSTGGMLTAARQTQYRKILVATEVGMLYQLRRAAPEIDFRAVNDR
EEECCCCCCCCCEEEEECCCEEEHHHHHHHHEEEEEHHHHHHHHHHHHCCCCCEEECCCC
ASCKYMKMITPGALLRCLVEGTDEVHVDSEIAAAGRRSVQRMIEIGLPGGGE
CCCEEEEECCHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA