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The map label for this gene is bioF [C]

Identifier: 221230095

GI number: 221230095

Start: 1439941

End: 1441098

Strand: Direct

Name: bioF [C]

Synonym: MLBr_01217

Alternate gene names: 221230095

Gene position: 1439941-1441098 (Clockwise)

Preceding gene: 221230094

Following gene: 221230096

Centisome position: 44.06

GC content: 66.15

Gene sequence:

>1158_bases
ATGAAGGTCCCGATCGAGACGTCACCGCTGGCCTGGCTGGAAGCAGTGGAGCAACAGCGCCGCGGGGCCGGGCTGCGCCG
TTCGCTGCGGCCGCGCTCAGCCGTTGCCACCGAGCTGGATCTGGCCTCCAACGACTATCTCGGTCTCTCCCAACATCCCG
ACGTCATCGACGGCGGCGTTGCGGCGTTGCGGGTTTGGGGTGCAGGTGCCACCGGATCCCGCCTGGTCACCGGCGATACC
ATACTGCACCACGAATTGGAATGCGAGCTAGCTGAATTTGTCGGCGCCTGTGTCGGCCTACTGTTTTCTTCCGGTTATGC
CGCCAACCTCGGGGCTGTTGTCGGTTTGTCCGGCCCGGGTTCGCTGATCGTCTCCGATGCCTATTCGCACGCGTCCCTGG
TGGATGCTTGCCGGCTGTCGCGGGCGCGGGTGGTGGTGACACCGCACTGTGACGTTGACGCCGTGGACACCGCGCTGAGG
TCATGCCACGAGGAGCGTGCGGTTGTTGTCACTGAGTCGGTGTTCAGCGCTGATGGTGTGCTGGCCCCTGTTTCGGAGTT
GCACGATGTATGCCGTCGGCACGGCGCGTTGCTCCTCGTAGACGAGGCGCACGGCCTCGGTGTGCGTGGTGGTGGGCGCG
GGCTGGTATACGAGGTCGGGCTGGCGGGTGCACCTGACGTGGTGATTACGACTACCATGTCCAAGGCGCTCGGCAGCCAG
GGTGGTGCGGTTCTCGGGTCGTCCGCGGTGCGTGCTCACCTGATCAATACCGCCCGTCCGTTCATCTTCGACACTGGTTT
GGCGCCTGCGGCGGTAGGTGCCGCGCGGGCCGCGCTGCAAATACTGAAGGCCGAGACGTGGCGCCCAGAGGCGGTGTTGC
AGCACGCCCGAACCTTGGCTAAGATCTGCGATCTGTCCGAGCTGCCGCAGTCGGCGGTGGTCTCAGTAGTGTTGGGCGAT
CCGGAGGTAGCGTTGGCCGCCGCGATCGCCTGCCTGGACGCCGGCGTGCGGGTGGGCTGCTTCCGGCCTCCGACTGTGCC
GGCCGGGACGTCGCGGCTGCGGTTGACTGCGCACGCGTCTCTCGATAGCGCTAAGTTGGAAGTGGCCCGGCGGGTGTTGA
CGGACGTTCTTGGTGGCTGTTGTGTGGCGCGCCGTTGA

Upstream 100 bases:

>100_bases
TCTGGTTTATGCAATGCCGCCATATATTTGCCCGCCGGCCGAGATCGCCCAGATCACCTCCGCGATGGTCGAAGTCGCGG
GACTCGTAGGCTGAAGGCCC

Downstream 100 bases:

>100_bases
CTGTCGTGGTCGTTACCGGCACTGACACGGGGGTCGGCAAGACCGTCGCCTGTGCAGCGCTGGCGTGTCACGCGCGTCAA
GCTGGTATCGAAGTGGCAGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDT
ILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALR
SCHEERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQ
GGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLAKICDLSELPQSAVVSVVLGD
PEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDVLGGCCVARR

Sequences:

>Translated_385_residues
MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDT
ILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALR
SCHEERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQ
GGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLAKICDLSELPQSAVVSVVLGD
PEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDVLGGCCVARR
>Mature_385_residues
MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGVAALRVWGAGATGSRLVTGDT
ILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPGSLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALR
SCHEERAVVVTESVFSADGVLAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQ
GGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLAKICDLSELPQSAVVSVVLGD
PEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHASLDSAKLEVARRVLTDVLGGCCVARR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=328, Percent_Identity=32.9268292682927, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI284448556, Length=328, Percent_Identity=32.9268292682927, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI83977442, Length=326, Percent_Identity=34.6625766871166, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI83977444, Length=326, Percent_Identity=34.6625766871166, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI83977440, Length=326, Percent_Identity=34.6625766871166, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4502025, Length=333, Percent_Identity=33.9339339339339, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI40316939, Length=333, Percent_Identity=33.9339339339339, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI4758668, Length=246, Percent_Identity=27.6422764227642, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI119220554, Length=362, Percent_Identity=24.0331491712707, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI5454084, Length=257, Percent_Identity=26.4591439688716, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=37.5, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1790046, Length=331, Percent_Identity=32.6283987915408, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71994529, Length=331, Percent_Identity=33.5347432024169, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566772, Length=281, Percent_Identity=26.6903914590747, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17560912, Length=256, Percent_Identity=25.78125, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560914, Length=256, Percent_Identity=25.78125, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71982625, Length=270, Percent_Identity=24.8148148148148, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71982617, Length=270, Percent_Identity=24.8148148148148, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320438, Length=383, Percent_Identity=29.5039164490862, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323954, Length=260, Percent_Identity=29.2307692307692, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=23.224043715847, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24662918, Length=344, Percent_Identity=29.3604651162791, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17137420, Length=347, Percent_Identity=32.2766570605187, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24653280, Length=371, Percent_Identity=23.989218328841, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653276, Length=371, Percent_Identity=23.989218328841, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24653278, Length=371, Percent_Identity=23.989218328841, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17136286, Length=260, Percent_Identity=26.1538461538462, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_MYCLB (B8ZR84)

Other databases:

- EMBL:   FM211192
- RefSeq:   YP_002503511.1
- ProteinModelPortal:   B8ZR84
- SMR:   B8ZR84
- EnsemblBacteria:   EBMYCT00000085700
- GeneID:   7327261
- GenomeReviews:   FM211192_GR
- GeneTree:   EBGT00050000015340
- HOGENOM:   HBG649839
- OMA:   PARVIDH
- ProtClustDB:   PRK05958
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 39831; Mature: 39831

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 27-27 BINDING 130-130 BINDING 176-176 BINDING 345-345

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGV
CCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
AALRVWGAGATGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPG
EEEEEECCCCCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
SLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCHEERAVVVTESVFSADGV
CEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEHHHHCCCCC
LAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQ
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHHHHHCCC
GGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLA
CCEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KICDLSELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHAS
HHHCHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECC
LDSAKLEVARRVLTDVLGGCCVARR
CCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVPIETSPLAWLEAVEQQRRGAGLRRSLRPRSAVATELDLASNDYLGLSQHPDVIDGGV
CCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
AALRVWGAGATGSRLVTGDTILHHELECELAEFVGACVGLLFSSGYAANLGAVVGLSGPG
EEEEEECCCCCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCC
SLIVSDAYSHASLVDACRLSRARVVVTPHCDVDAVDTALRSCHEERAVVVTESVFSADGV
CEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCEEEEEHHHHCCCCC
LAPVSELHDVCRRHGALLLVDEAHGLGVRGGGRGLVYEVGLAGAPDVVITTTMSKALGSQ
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEEEHHHHHCCC
GGAVLGSSAVRAHLINTARPFIFDTGLAPAAVGAARAALQILKAETWRPEAVLQHARTLA
CCEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KICDLSELPQSAVVSVVLGDPEVALAAAIACLDAGVRVGCFRPPTVPAGTSRLRLTAHAS
HHHCHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEEECC
LDSAKLEVARRVLTDVLGGCCVARR
CCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA