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The map label for this gene is bioA

Identifier: 221230094

GI number: 221230094

Start: 1438624

End: 1439934

Strand: Direct

Name: bioA

Synonym: MLBr_01216

Alternate gene names: 221230094

Gene position: 1438624-1439934 (Clockwise)

Preceding gene: 221230091

Following gene: 221230095

Centisome position: 44.02

GC content: 63.62

Gene sequence:

>1311_bases
ATGTCTGGGGCGACTTCCGGGTTGACGCCTGAGCAGATCGGCGCGATCGATGCCGCCCATCTGTGGCATCCCTACAGCAC
CATTGGTGCTGCTACCGGCGTTATACCACCTGTGGTCGCGGTCGCCGCTCACGGCGCATGGCTGACGCTGATCCGCGACG
GCAAGCCGATCGAGGCGCTCGACGCGATGAGCTCTTGGTGGACCGCGATCCATGGTCACGGCCACTCAGTGTTGGACGCG
GCGCTGACTACCCAACTGGGTGCGATGAATCACGTCATGTTTGGCGGATTGACTCACGAACCTGCGGCCCGGTTGGCGCA
GTTGCTGGTGGACATCACCCCGGCGGGTTTGGAGACGGTCTTCTTCAGCGACTCCGGGTCGGTTTCAGTGCAGGTCGCGG
TGAAGATGGCGTTGCAGTACTGGCGCAGCCGCGGTCAGCCGGCTAAGCGGCGGCTGATGACCTGGCGTGGTGGCTACCAT
GGGGACACCTTGACGCCGATGAGTATCTGCGACCCCGATGGCGGCATGCACTCGCTGTGGACTGACATTTTGGCGCGGCA
GGTGTTTGCCCCGCAGGTGCCCCGCGACTACGACCCTGCCTACAGTAAGGCCTTTGAGACGCAGCTGGCGCAGCACACCC
CCGAACTTGCGGCTGTGGTCGTCGAGCCGGTAGTGCAGGGCGCCGGTGGGATGCGTTTCCACGACCCACGGTATTTGTGT
GATGTGCGCGACATATGCCGGCGGCACGACGTGTTGTTGATTTTCGACGAGATCGCGACTGGCTTCGGGCGTACCGGTGA
GCTTTTCGCCGCAGACCACTGCGGGGTGAGCCCGGACATCATGTGTGTCGGCAAAGCCCTCACCGGCGGATACCTGAGCT
TGGCCGCCACCTTGTGCACAACCGATATCGCACACGCCATAAGCGTCGGTGCGGCCGGCGCGCTGATGCATGGACCCACG
TTCATGGCCAATCCTCTGGCCTGTGCCGTGTCGGTGGCCAGCGTCGAGGTGCTTCTGGGCCAGGACTGGAGGTCCCGCGT
TGCCGAAATATCGGCTGGCCTAACAGCTGGGCTCGAAGCTGCCCAGGGTTTACCCGGTGTGATCGATGTGCGTGTGTGCG
GTGCTATCGGCGTTATCGAATGCGACCGGTCGGTCGACCTGGCCGTTGCCACCCCGGCGGCGTTGGACCGACGTGTTTGG
CTGCGTCCGTTCCGGAATCTGGTTTATGCAATGCCGCCATATATTTGCCCGCCGGCCGAGATCGCCCAGATCACCTCCGC
GATGGTCGAAGTCGCGGGACTCGTAGGCTGA

Upstream 100 bases:

>100_bases
TCCACGATTGTCGGGGTTTGCGCGACCCACAGCAGGACGGCTCGAGACGGTTCGGGTATGACCCCGGCTAATCCGCCTTC
TTGCTTTACCCTCGATCTTT

Downstream 100 bases:

>100_bases
AGGCCCATGAAGGTCCCGATCGAGACGTCACCGCTGGCCTGGCTGGAAGCAGTGGAGCAACAGCGCCGCGGGGCCGGGCT
GCGCCGTTCGCTGCGGCCGC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDA
ALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYH
GDTLTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLC
DVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPT
FMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVW
LRPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG

Sequences:

>Translated_436_residues
MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDA
ALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYH
GDTLTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLC
DVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPT
FMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVW
LRPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG
>Mature_435_residues
SGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEALDAMSSWWTAIHGHGHSVLDAA
LTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETVFFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHG
DTLTPMSICDPDGGMHSLWTDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLCD
VRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCTTDIAHAISVGAAGALMHGPTF
MANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEAAQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVWL
RPFRNLVYAMPPYICPPAEIAQITSAMVEVAGLVG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=329, Percent_Identity=30.3951367781155, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI284507298, Length=217, Percent_Identity=36.405529953917, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI13994255, Length=348, Percent_Identity=27.5862068965517, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI226442705, Length=439, Percent_Identity=22.7790432801822, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=24.1645244215938, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI37574042, Length=446, Percent_Identity=22.8699551569507, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=50, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI145693181, Length=348, Percent_Identity=32.4712643678161, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1788044, Length=302, Percent_Identity=35.0993377483444, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1789759, Length=267, Percent_Identity=36.7041198501873, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789016, Length=384, Percent_Identity=27.6041666666667, Blast_Score=121, Evalue=9e-29,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=26.4397905759162, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786349, Length=398, Percent_Identity=28.391959798995, Blast_Score=96, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=340, Percent_Identity=27.6470588235294, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=157, Percent_Identity=40.1273885350318, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=449, Percent_Identity=24.4988864142539, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=360, Percent_Identity=25, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=39.6514161220044, Blast_Score=331, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323470, Length=383, Percent_Identity=31.331592689295, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=249, Percent_Identity=28.5140562248996, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357415, Length=325, Percent_Identity=28.6153846153846, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=26.6821345707657, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574759, Length=431, Percent_Identity=26.6821345707657, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356575, Length=348, Percent_Identity=24.4252873563218, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOA_MYCLE (P45488)

Other databases:

- EMBL:   U00010
- EMBL:   AL583921
- PIR:   S72701
- RefSeq:   NP_301880.1
- ProteinModelPortal:   P45488
- SMR:   P45488
- EnsemblBacteria:   EBMYCT00000028898
- GeneID:   910321
- GenomeReviews:   AL450380_GR
- KEGG:   mle:ML1216
- NMPDR:   fig|272631.1.peg.752
- Leproma:   ML1216
- GeneTree:   EBGT00050000015339
- HOGENOM:   HBG725944
- OMA:   DSMSHVM
- ProtClustDB:   PRK05964
- BioCyc:   MLEP272631:ML1216-MONOMER
- BRENDA:   2.6.1.62
- GO:   GO:0005737
- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF8
- TIGRFAMs:   TIGR00508

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.62

Molecular weight: Translated: 46112; Mature: 45980

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 25-25 BINDING 256-256 BINDING 285-285 BINDING 318-318 BINDING 320-320 BINDING 402-402

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEAL
CCCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCHHHH
DAMSSWWTAIHGHGHSVLDAALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEE
FFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHGDTLTPMSICDPDGGMHSLW
EECCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHH
TDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
DVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCT
HHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEECHHHCCHHHHHHHHHHH
TDIAHAISVGAAGALMHGPTFMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEA
HHHHHHHHHCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVWLRPFRNLVYAMPPYICPPAE
HCCCCCEEEEEECCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IAQITSAMVEVAGLVG
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGATSGLTPEQIGAIDAAHLWHPYSTIGAATGVIPPVVAVAAHGAWLTLIRDGKPIEAL
CCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHCHHHHHHHHHCCCCEEEEEECCCCHHHH
DAMSSWWTAIHGHGHSVLDAALTTQLGAMNHVMFGGLTHEPAARLAQLLVDITPAGLETV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCEEE
FFSDSGSVSVQVAVKMALQYWRSRGQPAKRRLMTWRGGYHGDTLTPMSICDPDGGMHSLW
EECCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHH
TDILARQVFAPQVPRDYDPAYSKAFETQLAQHTPELAAVVVEPVVQGAGGMRFHDPRYLC
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHH
DVRDICRRHDVLLIFDEIATGFGRTGELFAADHCGVSPDIMCVGKALTGGYLSLAATLCT
HHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCCEEECHHHCCHHHHHHHHHHH
TDIAHAISVGAAGALMHGPTFMANPLACAVSVASVEVLLGQDWRSRVAEISAGLTAGLEA
HHHHHHHHHCCCHHHHCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AQGLPGVIDVRVCGAIGVIECDRSVDLAVATPAALDRRVWLRPFRNLVYAMPPYICPPAE
HCCCCCEEEEEECCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHH
IAQITSAMVEVAGLVG
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002