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The map label for this gene is 221229622

Identifier: 221229622

GI number: 221229622

Start: 553383

End: 554345

Strand: Reverse

Name: 221229622

Synonym: MLBr_00453

Alternate gene names: NA

Gene position: 554345-553383 (Counterclockwise)

Preceding gene: 221229623

Following gene: 221229621

Centisome position: 16.96

GC content: 62.41

Gene sequence:

>963_bases
GTGACAACCAGCACAGCGGGGCTGAAAATGATCAGGGCTCCGCATCGGCTAATGACCGGGCGGGCCATCGACTGGGCGTA
TGCGGCTGGCTGGAGGGCTGTGCGCGCGATGCCGGAATCTGCTGCGCGTTTCGCATTCAACACCGGAGCGCGCTACGCAG
CCCGCAACGGCGGACCGGATCAATTGCGCAAGAACCTGGCCCGCATCATCGGTGTGCAAGCTGCCGATGTACCGGACGCA
CTGATACGCACCTCGCTGGCGTCTTATGCCCGCTATTGGCGGGAAGCGTTTCGTCTGCCGACAATGAATCCCCACACGGT
GGCAAAGCAGGTCGAGGCTTATGGCATCGACCTGCACCGTGTCGGGGAGGCCTTGGATGCTGGGCGCGGCGTTGTGCTGG
CATTGCCGCACAGCGGCAATTGGGATATGGCCGGCGTGTGGCTGGTGCAATGCCACGGTACCTTCACCACCGTCGCGGAA
CGACTCAAACCCGAGTCGCTGTATCGGCGTTTCATCAACTACCGTGAAAACCTCGGTTTCGAAGTACTGCCAATGTCTGC
GAACAAGGATACTGGCTTCCAAGCCCTCTTTGAGCTGCTGTGCGAGCGGTTGCGGTCCAACCGCGTGGTGTGTCTGATGG
CCGAGCGTGACCTCACCCGCACCGGCGTTGAGGTCGATTTCTTCGGCGAACCCACTCGCATGCCTGCAGGCCCAGCGAAG
CTCGCAATCAAGACCGGGGCTGCACTACTGCCGGTTCACTGCTGGTTCCAGGGCAGCGGCTGGGGCTTTTCGGTACACCC
AGCGCTGGATTGCACCAGCGGTGACGTCGGTGACGTCACCCAGGCGCTGGCCGACCAGTTCGCCCAGGACATCGCCGCCA
ACCCCACCGACTGGCACATGCTTCAGCCGCAATGGTTGGCTGACTTGTCCGATGCCAAGCGAGCGCAGCTGAGACCGAAT
TGA

Upstream 100 bases:

>100_bases
CCGATCGCATTGCCAGACCAGGCTACCCTAGCGCTAGCGACAGGACTAACGCGACGAATGGGGGCCAACCCGGTCCCGGA
AACCTGGGAACAGGCGAGCC

Downstream 100 bases:

>100_bases
GGGAAGCCTATGCGGATCGGGATGATCTGTCCATACTCGTTCGATGTGCCAGGCGGGGTGCAATCGCACGTCTTGCAACT
GGCCGAGGTGATGCGCGCGC

Product: lipid A biosynthesis lauroyl acyltransferase

Products: NA

Alternate protein names: PIM acyltransferase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFAFNTGARYAARNGGPDQLRKNLARIIGVQAADVPDA
LIRTSLASYARYWREAFRLPTMNPHTVAKQVEAYGIDLHRVGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAE
RLKPESLYRRFINYRENLGFEVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTGVEVDFFGEPTRMPAGPAK
LAIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQALADQFAQDIAANPTDWHMLQPQWLADLSDAKRAQLRPN

Sequences:

>Translated_320_residues
MTTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFAFNTGARYAARNGGPDQLRKNLARIIGVQAADVPDA
LIRTSLASYARYWREAFRLPTMNPHTVAKQVEAYGIDLHRVGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAE
RLKPESLYRRFINYRENLGFEVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTGVEVDFFGEPTRMPAGPAK
LAIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQALADQFAQDIAANPTDWHMLQPQWLADLSDAKRAQLRPN
>Mature_319_residues
TTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFAFNTGARYAARNGGPDQLRKNLARIIGVQAADVPDAL
IRTSLASYARYWREAFRLPTMNPHTVAKQVEAYGIDLHRVGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAER
LKPESLYRRFINYRENLGFEVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTGVEVDFFGEPTRMPAGPAKL
AIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQALADQFAQDIAANPTDWHMLQPQWLADLSDAKRAQLRPN

Specific function: Catalyzes the acylation to the position 6 of the alpha- 1,2-linked mannose residue of the phosphatidyl-myo-inositol dimannoside (PIM2) or monomannoside (PIM1) [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35367; Mature: 35236

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFAFNTGARYAARNGGPD
CCCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHCCCCCHH
QLRKNLARIIGVQAADVPDALIRTSLASYARYWREAFRLPTMNPHTVAKQVEAYGIDLHR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
VGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAERLKPESLYRRFINYRENLGF
HHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCCCE
EVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTGVEVDFFGEPTRMPAGPAK
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCCEEEECCCCCCCCCCCHH
LAIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQALADQFAQDIAANPTDWHM
EEEECCCEEEEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
LQPQWLADLSDAKRAQLRPN
ECHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTSTAGLKMIRAPHRLMTGRAIDWAYAAGWRAVRAMPESAARFAFNTGARYAARNGGPD
CCCHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHCCCCCHH
QLRKNLARIIGVQAADVPDALIRTSLASYARYWREAFRLPTMNPHTVAKQVEAYGIDLHR
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
VGEALDAGRGVVLALPHSGNWDMAGVWLVQCHGTFTTVAERLKPESLYRRFINYRENLGF
HHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHCCCE
EVLPMSANKDTGFQALFELLCERLRSNRVVCLMAERDLTRTGVEVDFFGEPTRMPAGPAK
EEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCCEEEECCCCCCCCCCCHH
LAIKTGAALLPVHCWFQGSGWGFSVHPALDCTSGDVGDVTQALADQFAQDIAANPTDWHM
EEEECCCEEEEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEE
LQPQWLADLSDAKRAQLRPN
ECHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]