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The map label for this gene is guaB [C]

Identifier: 220918425

GI number: 220918425

Start: 3707565

End: 3709001

Strand: Direct

Name: guaB [C]

Synonym: A2cp1_3329

Alternate gene names: 220918425

Gene position: 3707565-3709001 (Clockwise)

Preceding gene: 220918422

Following gene: 220918427

Centisome position: 73.72

GC content: 74.39

Gene sequence:

>1437_bases
ATGCGCTTCCTCCACCCGGAGCACGACGAGGCGCTCGAGCTGTCGCTCGAGGACGTGTTCCTCGTCCCCAGCTACTTCGA
CGGCGGCTCGCGGCTGGAGGTGGACCTCCGGCCGGTGGACTTCGCGGGCGGCTCCCACCCGGTCGTCTCCGCCAACATGA
ACGCGGTCACCGGCAAGCGGATGGCCGAGACCATGGCGCGGCTGGGCGGGCTCGGCGTCCTGCCGCAGGACATGAGCCTC
GAGACCGCGGCGCGGATCATCCAGCACATCCGGTCCGTGGACCCGCGCCACGACACGCCGCTCTCCGTCTCGCCCCGCGC
CACGCTGCGCGACGTGCAGGGGATCATCCGGAAGCGCGCGCACGACATGGTGGTGGTGGTGGACGACGAGCGCCGCCCGG
TCGGCATCGTGACGCACGCCGACCTGCGCGACCAGGACCAGTACTCGCCGGCCGCGTCGTTCATGTCGTCGCGCCTCGTG
ACCCTCCCGGCGGGCACGCCGAACCGCGAGGCGTTCCTGCGGATGGAGGAGCAGCGGGTGAAGGCCGCGCCGGTGGTGGA
CGGCGCGGGCCGGCTGGTCGGCGTCCTCACCCGCGACGACGCCGTGCGCCTGGAGCTGCTCGCGCCGGCGCTCGACCCCG
CCGGCCGGCTCATGGTCGCTGCCGCGGTGGGGATCTCCGCCGACGCCGCCACCTCGGCCGCGCGGCTCGCCGAGCTGGGC
GTCGCGGCGATCGTGCTCGACACCGCGCACGGGCACCAGCGCCGCATGGTCGAGGCGATCCGCGAGGTGCGGCGGGCCAT
CGGCGACCGGCTGCCGCTGGTGGCAGGGAACGTGTGCACGCCGGAGGGCACCCGGGACCTGCTCGACGCCGGCGCGGACG
TGGTCAAGGTGAACGTGGGCCCGGGCGCGATGTGCACCACGCGCATGCAGACCGGCGCCGGGCGCCCGACGTTCACGTCC
GTGCTCGCGTGCGCCCGCGAGGCGCACCGGCGCGGGCGGCACGTGTGGGCCGACGGCGGCGTCCGCGATCCGCGCGACGT
GGCGCTGTACCTCGCGGCCGGCGCCTCGCGCGTCATGATCGGGACGGCGCTCGCCGGCACGTACGAGAGCCCCGGCGACG
TGAAGGAGGATCGCGAGGGGCGGCCGTACAAGGAGAACTACGGCATGGCGAGCGCGCGCGCGGTGAGCGATCGCACCGCC
GGCATCGATCCGTTCGAGCGCGCGAAGAAGGGCTTCTTCCGCGAGGGCATCTCCACCTCGCGCATCTACATCCGCGAGGG
CCGGGAGAGCGTGGGCGCGATCCTGGTGGACGTGATCACCGGGGTGCAGTCGGCGTTCACCTACGCCGGCGCGGCGTCGG
TGCCCGAGTTCCACCGCAAGGCGGTGGTGGGCGTGCAGACCGCGGGCGGCTACGTCGAGGGCAAGCCCCGCGGGTGA

Upstream 100 bases:

>100_bases
CGCGCGGGCACGGCGGCCGAGGGTGCGACCGACCGCCCACCTGCCCGCTCCGTCCGTCCTGGGATGGGCACGGCCCGCCC
GTCCGGCTTATCCGGTGGAC

Downstream 100 bases:

>100_bases
GCGGCCGCGGCCCGGGACGCATCCGGGCCGCTCGGCGCCCGCCCGTTCGTCGCGCCAGGTGCACCGAGCCGGCCGGCGTC
AGCGGGCGGCGTGCGTGCGG

Product: inosine 5-monophosphate dehydrogenase

Products: xanthosine 5'-phosphate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MRFLHPEHDEALELSLEDVFLVPSYFDGGSRLEVDLRPVDFAGGSHPVVSANMNAVTGKRMAETMARLGGLGVLPQDMSL
ETAARIIQHIRSVDPRHDTPLSVSPRATLRDVQGIIRKRAHDMVVVVDDERRPVGIVTHADLRDQDQYSPAASFMSSRLV
TLPAGTPNREAFLRMEEQRVKAAPVVDGAGRLVGVLTRDDAVRLELLAPALDPAGRLMVAAAVGISADAATSAARLAELG
VAAIVLDTAHGHQRRMVEAIREVRRAIGDRLPLVAGNVCTPEGTRDLLDAGADVVKVNVGPGAMCTTRMQTGAGRPTFTS
VLACAREAHRRGRHVWADGGVRDPRDVALYLAAGASRVMIGTALAGTYESPGDVKEDREGRPYKENYGMASARAVSDRTA
GIDPFERAKKGFFREGISTSRIYIREGRESVGAILVDVITGVQSAFTYAGAASVPEFHRKAVVGVQTAGGYVEGKPRG

Sequences:

>Translated_478_residues
MRFLHPEHDEALELSLEDVFLVPSYFDGGSRLEVDLRPVDFAGGSHPVVSANMNAVTGKRMAETMARLGGLGVLPQDMSL
ETAARIIQHIRSVDPRHDTPLSVSPRATLRDVQGIIRKRAHDMVVVVDDERRPVGIVTHADLRDQDQYSPAASFMSSRLV
TLPAGTPNREAFLRMEEQRVKAAPVVDGAGRLVGVLTRDDAVRLELLAPALDPAGRLMVAAAVGISADAATSAARLAELG
VAAIVLDTAHGHQRRMVEAIREVRRAIGDRLPLVAGNVCTPEGTRDLLDAGADVVKVNVGPGAMCTTRMQTGAGRPTFTS
VLACAREAHRRGRHVWADGGVRDPRDVALYLAAGASRVMIGTALAGTYESPGDVKEDREGRPYKENYGMASARAVSDRTA
GIDPFERAKKGFFREGISTSRIYIREGRESVGAILVDVITGVQSAFTYAGAASVPEFHRKAVVGVQTAGGYVEGKPRG
>Mature_478_residues
MRFLHPEHDEALELSLEDVFLVPSYFDGGSRLEVDLRPVDFAGGSHPVVSANMNAVTGKRMAETMARLGGLGVLPQDMSL
ETAARIIQHIRSVDPRHDTPLSVSPRATLRDVQGIIRKRAHDMVVVVDDERRPVGIVTHADLRDQDQYSPAASFMSSRLV
TLPAGTPNREAFLRMEEQRVKAAPVVDGAGRLVGVLTRDDAVRLELLAPALDPAGRLMVAAAVGISADAATSAARLAELG
VAAIVLDTAHGHQRRMVEAIREVRRAIGDRLPLVAGNVCTPEGTRDLLDAGADVVKVNVGPGAMCTTRMQTGAGRPTFTS
VLACAREAHRRGRHVWADGGVRDPRDVALYLAAGASRVMIGTALAGTYESPGDVKEDREGRPYKENYGMASARAVSDRTA
GIDPFERAKKGFFREGISTSRIYIREGRESVGAILVDVITGVQSAFTYAGAASVPEFHRKAVVGVQTAGGYVEGKPRG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=459, Percent_Identity=28.1045751633987, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI34328928, Length=463, Percent_Identity=28.0777537796976, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI217035146, Length=463, Percent_Identity=28.0777537796976, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI156616279, Length=463, Percent_Identity=28.0777537796976, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI34328930, Length=463, Percent_Identity=28.0777537796976, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI217035152, Length=459, Percent_Identity=28.1045751633987, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI50541954, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI50541952, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI50541948, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI50541956, Length=223, Percent_Identity=38.5650224215247, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI217035148, Length=463, Percent_Identity=28.0777537796976, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI156104880, Length=221, Percent_Identity=37.5565610859729, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI217035150, Length=462, Percent_Identity=27.0562770562771, Blast_Score=125, Evalue=8e-29,
Organism=Escherichia coli, GI1788855, Length=468, Percent_Identity=34.8290598290598, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1786293, Length=217, Percent_Identity=35.4838709677419, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17560440, Length=232, Percent_Identity=38.7931034482759, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71994385, Length=492, Percent_Identity=26.219512195122, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71994389, Length=437, Percent_Identity=26.7734553775744, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323585, Length=356, Percent_Identity=30.0561797752809, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6323464, Length=391, Percent_Identity=28.9002557544757, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322012, Length=395, Percent_Identity=29.1139240506329, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=26.6272189349112, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641071, Length=393, Percent_Identity=30.7888040712468, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24641073, Length=393, Percent_Identity=30.7888040712468, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI28571163, Length=352, Percent_Identity=30.6818181818182, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR018529
- InterPro:   IPR001093
- InterPro:   IPR005991 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: 1.1.1.205

Molecular weight: Translated: 51173; Mature: 51173

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLHPEHDEALELSLEDVFLVPSYFDGGSRLEVDLRPVDFAGGSHPVVSANMNAVTGKR
CCCCCCCCCCHHEEEECEEEEEECCCCCCCEEEEEEEEEECCCCCCCEEECCCCHHHHHH
MAETMARLGGLGVLPQDMSLETAARIIQHIRSVDPRHDTPLSVSPRATLRDVQGIIRKRA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
HDMVVVVDDERRPVGIVTHADLRDQDQYSPAASFMSSRLVTLPAGTPNREAFLRMEEQRV
CCEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHHH
KAAPVVDGAGRLVGVLTRDDAVRLELLAPALDPAGRLMVAAAVGISADAATSAARLAELG
HHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHC
VAAIVLDTAHGHQRRMVEAIREVRRAIGDRLPLVAGNVCTPEGTRDLLDAGADVVKVNVG
EEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCCEEEEECC
PGAMCTTRMQTGAGRPTFTSVLACAREAHRRGRHVWADGGVRDPRDVALYLAAGASRVMI
CCCEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHEEEEEECCCCEEEE
GTALAGTYESPGDVKEDREGRPYKENYGMASARAVSDRTAGIDPFERAKKGFFREGISTS
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RIYIREGRESVGAILVDVITGVQSAFTYAGAASVPEFHRKAVVGVQTAGGYVEGKPRG
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCEECCCCCC
>Mature Secondary Structure
MRFLHPEHDEALELSLEDVFLVPSYFDGGSRLEVDLRPVDFAGGSHPVVSANMNAVTGKR
CCCCCCCCCCHHEEEECEEEEEECCCCCCCEEEEEEEEEECCCCCCCEEECCCCHHHHHH
MAETMARLGGLGVLPQDMSLETAARIIQHIRSVDPRHDTPLSVSPRATLRDVQGIIRKRA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
HDMVVVVDDERRPVGIVTHADLRDQDQYSPAASFMSSRLVTLPAGTPNREAFLRMEEQRV
CCEEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHCCEEEECCCCCCHHHHHHHHHHHH
KAAPVVDGAGRLVGVLTRDDAVRLELLAPALDPAGRLMVAAAVGISADAATSAARLAELG
HHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHC
VAAIVLDTAHGHQRRMVEAIREVRRAIGDRLPLVAGNVCTPEGTRDLLDAGADVVKVNVG
EEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHCCCCEEEEECC
PGAMCTTRMQTGAGRPTFTSVLACAREAHRRGRHVWADGGVRDPRDVALYLAAGASRVMI
CCCEEEEHHHCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHEEEEEECCCCEEEE
GTALAGTYESPGDVKEDREGRPYKENYGMASARAVSDRTAGIDPFERAKKGFFREGISTS
EEEECCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
RIYIREGRESVGAILVDVITGVQSAFTYAGAASVPEFHRKAVVGVQTAGGYVEGKPRG
EEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHEEEEECCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: inosine 5'-phosphate; NAD+; H2O

Specific reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]