Click here to switch to the map view.

The map label for this gene is phoR [H]

Identifier: 220917914

GI number: 220917914

Start: 3112767

End: 3114005

Strand: Direct

Name: phoR [H]

Synonym: A2cp1_2815

Alternate gene names: 220917914

Gene position: 3112767-3114005 (Clockwise)

Preceding gene: 220917913

Following gene: 220917915

Centisome position: 61.89

GC content: 73.85

Gene sequence:

>1239_bases
GTGGCCGCCTACGCCCTGGTCAGCCTGCTCTGGATCGCGTTCTCCGACGCGCTGCTGTTCCACCTCGTGCCCGATCCGGT
CCTGCGGGGCCGGGCGCAGACCGTGAAGGGCGCGTTCTTCGTGGTGGTCACCTCCGCGCTGCTGCTCGAGCTGATCCGGC
GCGGCGACCTGGGCCTGCGCACGCTGGGCGCCGAGGTGCGCGCCACCGTGGACAGCATGGTGGACGCGGTGCTCCTGGTG
GACGAGGAAGGTCGCATCGTGGAGACGAACCGCGCGGCCGTCGAGCTGCTCGGGGTCGCCTCGAAGGAGGACCTGCTCGT
CCCGCTCCGCGACTGGGGGCGACGCTTCGACCTGCGGTACCTGGACGGCACGCCGGTGCCCTACGAGCGCTACGCGGCGG
TGCGGGCGCTCTCCGGCGAGCGCATCAAGGCGTACGACGCGATGGCCCGGCGGGCCGACGGCGCCGACGTCTACTTCAGC
GTCTCGGCCGCGCCGGTGGAGGGCGCCGGGCACCGCGTGCTGGCGGTGGCGGTGCTGCGCGACGTCACCGCCGCCCGCCG
GCTCGACGAGATGCGCGAGGAGTTCCTCTCGACCGCCGCGCACGAGTTCAAGACCCCGCTCGCGGTCGTGAAGGCCTACG
CGCAGCTCATGCAGAAGCGCGCGCCCGGCGATCCGGGCCTGGCGGTGATCCAGCGGCAGGTGGACCGGCTCAACCGCCTG
GTGCAGCACCTGCTCGACACGTCGCGCCTGCGCCTCCAGGGTGGCGAGGGCCGCCGCGACACGTTCGACGTGTCCTCCCT
CGTCGCCGAGGCCATCGAGGAGGCGCGCCCGTCCACGCCCGGCCACGCGCTCGAGGCGGACGCGCCCGCGCCCGCGGTGG
TCCACGCGGATCGCGAGCGGATCCTGCGCGTGCTCACCAGCCTGCTCGACAACGCCATCCGGTTCTCGCCGGCGGGCGGC
CCGGTGCAGGTGCGGGTGGAGACGCTGAGCGGCGAGGTGGTCGTCTCGGTGGCGGACCACGGGCTGGGGATCCCACCCGA
GCGGCAGCCGCGCATCTTCGAGCGCTACTACCGCGCGCACGCCGGCACCGACCAGGACTACGGCGGCCTCGGCCTGGGGC
TCGACATGAGCCGCGAGATCGTCACCCGCCACGGCGGCCGGATGTGGTTCGAGAGCGTCCCGGGTCAGGGCTCCACCTTC
CACTTCAGCCTGCCGCTCGCGGCGCAGGAGGCCTCGTGA

Upstream 100 bases:

>100_bases
GGCCGGTGGTGACAGGCCCCTCGCCTCCCTGCCGGGGACGGAGCCCGCGCGAGCCTCGCGGTGGTGGCGCGGCCGGAGCG
CCTGGTCGCCGGGCCGCATC

Downstream 100 bases:

>100_bases
GGCGCAGCGTGCTCGTGGTGGAGGACGACCAGGACCTGTCGTCGCTCCTCGAGATGGTCCTCGCCGACGCGGGCCACCGG
GTGCGCACCGCCCCGGACGG

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MAAYALVSLLWIAFSDALLFHLVPDPVLRGRAQTVKGAFFVVVTSALLLELIRRGDLGLRTLGAEVRATVDSMVDAVLLV
DEEGRIVETNRAAVELLGVASKEDLLVPLRDWGRRFDLRYLDGTPVPYERYAAVRALSGERIKAYDAMARRADGADVYFS
VSAAPVEGAGHRVLAVAVLRDVTAARRLDEMREEFLSTAAHEFKTPLAVVKAYAQLMQKRAPGDPGLAVIQRQVDRLNRL
VQHLLDTSRLRLQGGEGRRDTFDVSSLVAEAIEEARPSTPGHALEADAPAPAVVHADRERILRVLTSLLDNAIRFSPAGG
PVQVRVETLSGEVVVSVADHGLGIPPERQPRIFERYYRAHAGTDQDYGGLGLGLDMSREIVTRHGGRMWFESVPGQGSTF
HFSLPLAAQEAS

Sequences:

>Translated_412_residues
MAAYALVSLLWIAFSDALLFHLVPDPVLRGRAQTVKGAFFVVVTSALLLELIRRGDLGLRTLGAEVRATVDSMVDAVLLV
DEEGRIVETNRAAVELLGVASKEDLLVPLRDWGRRFDLRYLDGTPVPYERYAAVRALSGERIKAYDAMARRADGADVYFS
VSAAPVEGAGHRVLAVAVLRDVTAARRLDEMREEFLSTAAHEFKTPLAVVKAYAQLMQKRAPGDPGLAVIQRQVDRLNRL
VQHLLDTSRLRLQGGEGRRDTFDVSSLVAEAIEEARPSTPGHALEADAPAPAVVHADRERILRVLTSLLDNAIRFSPAGG
PVQVRVETLSGEVVVSVADHGLGIPPERQPRIFERYYRAHAGTDQDYGGLGLGLDMSREIVTRHGGRMWFESVPGQGSTF
HFSLPLAAQEAS
>Mature_411_residues
AAYALVSLLWIAFSDALLFHLVPDPVLRGRAQTVKGAFFVVVTSALLLELIRRGDLGLRTLGAEVRATVDSMVDAVLLVD
EEGRIVETNRAAVELLGVASKEDLLVPLRDWGRRFDLRYLDGTPVPYERYAAVRALSGERIKAYDAMARRADGADVYFSV
SAAPVEGAGHRVLAVAVLRDVTAARRLDEMREEFLSTAAHEFKTPLAVVKAYAQLMQKRAPGDPGLAVIQRQVDRLNRLV
QHLLDTSRLRLQGGEGRRDTFDVSSLVAEAIEEARPSTPGHALEADAPAPAVVHADRERILRVLTSLLDNAIRFSPAGGP
VQVRVETLSGEVVVSVADHGLGIPPERQPRIFERYYRAHAGTDQDYGGLGLGLDMSREIVTRHGGRMWFESVPGQGSTFH
FSLPLAAQEAS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=358, Percent_Identity=27.3743016759777, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788549, Length=362, Percent_Identity=25.9668508287293, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=30.7017543859649, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=28.9592760180996, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=26.6129032258064, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790300, Length=361, Percent_Identity=27.9778393351801, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788713, Length=374, Percent_Identity=22.192513368984, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI48994928, Length=288, Percent_Identity=26.7361111111111, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI145693157, Length=313, Percent_Identity=23.6421725239617, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=31.0502283105023, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=26.7543859649123, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=268, Percent_Identity=26.1194029850746, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=234, Percent_Identity=28.2051282051282, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787894, Length=245, Percent_Identity=26.9387755102041, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=198, Percent_Identity=30.8080808080808, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786783, Length=103, Percent_Identity=36.8932038834951, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=212, Percent_Identity=30.188679245283, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45009; Mature: 44878

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYALVSLLWIAFSDALLFHLVPDPVLRGRAQTVKGAFFVVVTSALLLELIRRGDLGLR
CHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TLGAEVRATVDSMVDAVLLVDEEGRIVETNRAAVELLGVASKEDLLVPLRDWGRRFDLRY
HHHHHHHHHHHHHHCEEEEECCCCCEEECCHHHHHHHHCCCCCCCEEEHHHCCCEEEEEE
LDGTPVPYERYAAVRALSGERIKAYDAMARRADGADVYFSVSAAPVEGAGHRVLAVAVLR
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
DVTAARRLDEMREEFLSTAAHEFKTPLAVVKAYAQLMQKRAPGDPGLAVIQRQVDRLNRL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VQHLLDTSRLRLQGGEGRRDTFDVSSLVAEAIEEARPSTPGHALEADAPAPAVVHADRER
HHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHH
ILRVLTSLLDNAIRFSPAGGPVQVRVETLSGEVVVSVADHGLGIPPERQPRIFERYYRAH
HHHHHHHHHHHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
AGTDQDYGGLGLGLDMSREIVTRHGGRMWFESVPGQGSTFHFSLPLAAQEAS
CCCCCCCCCEECCCCCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
AAYALVSLLWIAFSDALLFHLVPDPVLRGRAQTVKGAFFVVVTSALLLELIRRGDLGLR
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TLGAEVRATVDSMVDAVLLVDEEGRIVETNRAAVELLGVASKEDLLVPLRDWGRRFDLRY
HHHHHHHHHHHHHHCEEEEECCCCCEEECCHHHHHHHHCCCCCCCEEEHHHCCCEEEEEE
LDGTPVPYERYAAVRALSGERIKAYDAMARRADGADVYFSVSAAPVEGAGHRVLAVAVLR
ECCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
DVTAARRLDEMREEFLSTAAHEFKTPLAVVKAYAQLMQKRAPGDPGLAVIQRQVDRLNRL
HHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
VQHLLDTSRLRLQGGEGRRDTFDVSSLVAEAIEEARPSTPGHALEADAPAPAVVHADRER
HHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCHHH
ILRVLTSLLDNAIRFSPAGGPVQVRVETLSGEVVVSVADHGLGIPPERQPRIFERYYRAH
HHHHHHHHHHHHEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
AGTDQDYGGLGLGLDMSREIVTRHGGRMWFESVPGQGSTFHFSLPLAAQEAS
CCCCCCCCCEECCCCCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]