Click here to switch to the map view.

The map label for this gene is arlR [H]

Identifier: 220917915

GI number: 220917915

Start: 3114002

End: 3114397

Strand: Direct

Name: arlR [H]

Synonym: A2cp1_2816

Alternate gene names: 220917915

Gene position: 3114002-3114397 (Clockwise)

Preceding gene: 220917914

Following gene: 220917916

Centisome position: 61.92

GC content: 74.49

Gene sequence:

>396_bases
GTGAGGCGCAGCGTGCTCGTGGTGGAGGACGACCAGGACCTGTCGTCGCTCCTCGAGATGGTCCTCGCCGACGCGGGCCA
CCGGGTGCGCACCGCCCCGGACGGCCGGGCCGCGCTGGCGGCCGTGGCCGCGGAGATGCCGGGCGTCATCCTGCTCGACA
TGCGCATGCCGGTCATGAACGGGTGGGAGTTCGCGCGCGAGTTCCGCAGCCGCTACGGCCGGGCCTGCCCGATCGTGGTG
GTCACCGCGGCGGAGAACGCCCGCCTGCGGGCGGAGGAGATCGGCGCGGAGGACTGGCTGGCCAAGCCGTTCGACCTCGA
CGACGTGCTGTACACGGTCGAGCGCCAGCTCGGCGGCGGGGACGAGGGCGGCGCGCCCACGCGGTCGCTGCACTGA

Upstream 100 bases:

>100_bases
AGATCGTCACCCGCCACGGCGGCCGGATGTGGTTCGAGAGCGTCCCGGGTCAGGGCTCCACCTTCCACTTCAGCCTGCCG
CTCGCGGCGCAGGAGGCCTC

Downstream 100 bases:

>100_bases
CGCCCGGCCGTCGGCCGTCGCCGGACCGCGCGGGCGTCGGGGCCCCGGCCATCCGGTTGGGTCGTCGCCGCCCCGCGCAC
CCGATCCCACCGTCTGAGCG

Product: response regulator receiver protein

Products: NADP; 2 glutathione [C]

Alternate protein names: NA

Number of amino acids: Translated: 131; Mature: 131

Protein sequence:

>131_residues
MRRSVLVVEDDQDLSSLLEMVLADAGHRVRTAPDGRAALAAVAAEMPGVILLDMRMPVMNGWEFAREFRSRYGRACPIVV
VTAAENARLRAEEIGAEDWLAKPFDLDDVLYTVERQLGGGDEGGAPTRSLH

Sequences:

>Translated_131_residues
MRRSVLVVEDDQDLSSLLEMVLADAGHRVRTAPDGRAALAAVAAEMPGVILLDMRMPVMNGWEFAREFRSRYGRACPIVV
VTAAENARLRAEEIGAEDWLAKPFDLDDVLYTVERQLGGGDEGGAPTRSLH
>Mature_131_residues
MRRSVLVVEDDQDLSSLLEMVLADAGHRVRTAPDGRAALAAVAAEMPGVILLDMRMPVMNGWEFAREFRSRYGRACPIVV
VTAAENARLRAEEIGAEDWLAKPFDLDDVLYTVERQLGGGDEGGAPTRSLH

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence [H]

COG id: COG0784

COG function: function code T; FOG: CheY-like receiver

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=129, Percent_Identity=35.6589147286822, Blast_Score=76, Evalue=8e-16,
Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=35.6521739130435, Blast_Score=72, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=7e-13,
Organism=Escherichia coli, GI1787375, Length=108, Percent_Identity=34.2592592592593, Blast_Score=63, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=116, Percent_Identity=32.7586206896552, Blast_Score=62, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=34.9514563106796, Blast_Score=60, Evalue=4e-11,
Organism=Escherichia coli, GI1789809, Length=129, Percent_Identity=31.7829457364341, Blast_Score=60, Evalue=6e-11,
Organism=Escherichia coli, GI1786911, Length=108, Percent_Identity=34.2592592592593, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 14351; Mature: 14351

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSVLVVEDDQDLSSLLEMVLADAGHRVRTAPDGRAALAAVAAEMPGVILLDMRMPVMN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCC
GWEFAREFRSRYGRACPIVVVTAAENARLRAEEIGAEDWLAKPFDLDDVLYTVERQLGGG
CHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCC
DEGGAPTRSLH
CCCCCCCCCCC
>Mature Secondary Structure
MRRSVLVVEDDQDLSSLLEMVLADAGHRVRTAPDGRAALAAVAAEMPGVILLDMRMPVMN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCC
GWEFAREFRSRYGRACPIVVVTAAENARLRAEEIGAEDWLAKPFDLDDVLYTVERQLGGG
CHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHCCCHHHCCCCCCHHHHHHHHHHHHCCC
DEGGAPTRSLH
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA