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The map label for this gene is lpxK

Identifier: 220917893

GI number: 220917893

Start: 3087688

End: 3088827

Strand: Reverse

Name: lpxK

Synonym: A2cp1_2794

Alternate gene names: 220917893

Gene position: 3088827-3087688 (Counterclockwise)

Preceding gene: 220917894

Following gene: 220917892

Centisome position: 61.42

GC content: 82.19

Gene sequence:

>1140_bases
ATGAGCGGGCTCGAGGCGATCTGGTGGCGCGAGCGCCCGGGGCCCCTGGGGGCGCTGGCGGGCGCGCCGCTGCTGCTCGC
CGAGGCGCCGTTCCGCGCCGCCGCGGCGCTCCGGGGCGCGCTGTACGATCGCGGGGTCCTGCCGGCCGTCCGGGCGGGCG
CGCCGGTCGTCTCCATCGGGAACCTCGCGGTGGGCGGGGCCGGAAAGACGCCGGCGGCGCTGGCGGTGGCGGCGCGCCTG
GCCGGGCGCGGCCGCCGGGTCGCGATCCTCTCCCGCGGCTACGGCGCCGCGCGCGCGGACGCCCGGGTCGCCTCCGACGG
CGCGGGCGCGCTGCTGCCCGCGGCCGAGGCCGGCGACGAGCCGGCGCTGCTCGCGCGCCGCCTGCCCGGCGTGGCGGTGC
TGTGCGGGCCGCGCCGCGCCGAGCTGGCCCGCACCGCGGTGGAGGCGCTCGGCGCCGACGCCCTGGTGCTCGACGACGGC
TTCCAGCACCGCGCGCTCGCGCGCGACCTCGACGTGGTGGTGCTCGACGCGTCGAACCCGTTCGGCAACGGCCACCTCCT
GCCGCGCGGGCCCAACCGCGAGCCGCGGACCGCGCTGCGCCGCGCCGGGCTGGTCTGGCTCTCGCACGCGGACCGGGCCG
CGCCGGAGCGGCTGGAGGCGCTCCGCGCGCTCGCCCGCGACGCCACCGGCCGCGCGCCGGTGGAGTCGCGCCACGCGGCC
ACCGCGCTGCTCGACGGCGCCCTGCGGGAGGCGGGATCGCTGGAGGCGCTCCGGGGCCGCCGGGTCGCCGCGCTGTCCGG
CCTCGCCCGGCCGGCAGGGTTCCTGCGCACGCTCGAGGCGCTCGGCGCCGAGGTCGCGCTCGCGCGCGCCTTCCCCGACC
ACCACCGCTTCACCGCCGGCGAGCTCGAGGCGGTCCTCCGCGACGGCGACGCCGCGGGCTGCGCCTGGGTGGTCACCACG
GAGAAGGACGCGGTCCGCCTCGACCCCGCGCTGGCCGCGGGAGCGGCCGGCCGGCTCCGCGTGGTCCGCGTGGACGCGGA
GCTCCTGCGCGGCGCCGACGTCCTCGAGGCCGCGCTCGACGCGGCGCTCGCCGCCGCCGCCCCTCAACCCCGACCGGCGC
CGCGCGCCCCGGTGTCCTGA

Upstream 100 bases:

>100_bases
CGAACCACGGCGGCGACTACTGCCCCGAGGGCCACCACCGCTGCCTCGCGGACCTGGCGCCGCAGGCGGTGCTGGCCAGC
GCGCGAGAGATGCTGCGGCG

Downstream 100 bases:

>100_bases
TCATGCGCCTGCTCGGCTGGATCTTCGCCCGCCTCCCGTACCGCTGGATCATGGCGCTCGGCGCCGCGCTGGGCGCGCTG
GTCTGGGGGCTCGGCATCCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSGLEAIWWRERPGPLGALAGAPLLLAEAPFRAAAALRGALYDRGVLPAVRAGAPVVSIGNLAVGGAGKTPAALAVAARL
AGRGRRVAILSRGYGAARADARVASDGAGALLPAAEAGDEPALLARRLPGVAVLCGPRRAELARTAVEALGADALVLDDG
FQHRALARDLDVVVLDASNPFGNGHLLPRGPNREPRTALRRAGLVWLSHADRAAPERLEALRALARDATGRAPVESRHAA
TALLDGALREAGSLEALRGRRVAALSGLARPAGFLRTLEALGAEVALARAFPDHHRFTAGELEAVLRDGDAAGCAWVVTT
EKDAVRLDPALAAGAAGRLRVVRVDAELLRGADVLEAALDAALAAAAPQPRPAPRAPVS

Sequences:

>Translated_379_residues
MSGLEAIWWRERPGPLGALAGAPLLLAEAPFRAAAALRGALYDRGVLPAVRAGAPVVSIGNLAVGGAGKTPAALAVAARL
AGRGRRVAILSRGYGAARADARVASDGAGALLPAAEAGDEPALLARRLPGVAVLCGPRRAELARTAVEALGADALVLDDG
FQHRALARDLDVVVLDASNPFGNGHLLPRGPNREPRTALRRAGLVWLSHADRAAPERLEALRALARDATGRAPVESRHAA
TALLDGALREAGSLEALRGRRVAALSGLARPAGFLRTLEALGAEVALARAFPDHHRFTAGELEAVLRDGDAAGCAWVVTT
EKDAVRLDPALAAGAAGRLRVVRVDAELLRGADVLEAALDAALAAAAPQPRPAPRAPVS
>Mature_378_residues
SGLEAIWWRERPGPLGALAGAPLLLAEAPFRAAAALRGALYDRGVLPAVRAGAPVVSIGNLAVGGAGKTPAALAVAARLA
GRGRRVAILSRGYGAARADARVASDGAGALLPAAEAGDEPALLARRLPGVAVLCGPRRAELARTAVEALGADALVLDDGF
QHRALARDLDVVVLDASNPFGNGHLLPRGPNREPRTALRRAGLVWLSHADRAAPERLEALRALARDATGRAPVESRHAAT
ALLDGALREAGSLEALRGRRVAALSGLARPAGFLRTLEALGAEVALARAFPDHHRFTAGELEAVLRDGDAAGCAWVVTTE
KDAVRLDPALAAGAAGRLRVVRVDAELLRGADVLEAALDAALAAAAPQPRPAPRAPVS

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=285, Percent_Identity=34.3859649122807, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_ANAD2 (B8JE66)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002493197.1
- GeneID:   7298867
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2794
- HOGENOM:   HBG663914
- ProtClustDB:   CLSK946293
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 38825; Mature: 38694

Theoretical pI: Translated: 11.11; Mature: 11.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLEAIWWRERPGPLGALAGAPLLLAEAPFRAAAALRGALYDRGVLPAVRAGAPVVSIG
CCCCCCEEECCCCCCCCHHCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEEC
NLAVGGAGKTPAALAVAARLAGRGRRVAILSRGYGAARADARVASDGAGALLPAAEAGDE
CEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCEEECCCCCCC
PALLARRLPGVAVLCGPRRAELARTAVEALGADALVLDDGFQHRALARDLDVVVLDASNP
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCEEEEECCCC
FGNGHLLPRGPNREPRTALRRAGLVWLSHADRAAPERLEALRALARDATGRAPVESRHAA
CCCCEECCCCCCCCHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
TALLDGALREAGSLEALRGRRVAALSGLARPAGFLRTLEALGAEVALARAFPDHHRFTAG
HHHHHHHHHHCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ELEAVLRDGDAAGCAWVVTTEKDAVRLDPALAAGAAGRLRVVRVDAELLRGADVLEAALD
HHHHHHHCCCCCCEEEEEECCCCCEEECHHHHCCCCCCEEEEEECHHHHCCHHHHHHHHH
AALAAAAPQPRPAPRAPVS
HHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SGLEAIWWRERPGPLGALAGAPLLLAEAPFRAAAALRGALYDRGVLPAVRAGAPVVSIG
CCCCCEEECCCCCCCCHHCCCCEEEECCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEEC
NLAVGGAGKTPAALAVAARLAGRGRRVAILSRGYGAARADARVASDGAGALLPAAEAGDE
CEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEECCCCCCCEEECCCCCCC
PALLARRLPGVAVLCGPRRAELARTAVEALGADALVLDDGFQHRALARDLDVVVLDASNP
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCEEEEECCCC
FGNGHLLPRGPNREPRTALRRAGLVWLSHADRAAPERLEALRALARDATGRAPVESRHAA
CCCCEECCCCCCCCHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
TALLDGALREAGSLEALRGRRVAALSGLARPAGFLRTLEALGAEVALARAFPDHHRFTAG
HHHHHHHHHHCCCHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
ELEAVLRDGDAAGCAWVVTTEKDAVRLDPALAAGAAGRLRVVRVDAELLRGADVLEAALD
HHHHHHHCCCCCCEEEEEECCCCCEEECHHHHCCCCCCEEEEEECHHHHCCHHHHHHHHH
AALAAAAPQPRPAPRAPVS
HHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA