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The map label for this gene is htrB [H]

Identifier: 220917892

GI number: 220917892

Start: 3086798

End: 3087685

Strand: Reverse

Name: htrB [H]

Synonym: A2cp1_2793

Alternate gene names: 220917892

Gene position: 3087685-3086798 (Counterclockwise)

Preceding gene: 220917893

Following gene: 220917891

Centisome position: 61.39

GC content: 74.77

Gene sequence:

>888_bases
ATGCGCCTGCTCGGCTGGATCTTCGCCCGCCTCCCGTACCGCTGGATCATGGCGCTCGGCGCCGCGCTGGGCGCGCTGGT
CTGGGGGCTCGGCATCCGCCGGCGCGTGGTGCTGGAGAACCTGCGCCTCGCCTTCCCCGACCGCCCCGAGGCGGAGCGGC
GCGCCATCGCGCGCACCACGTACCGCAACCTGGGGCAGATGATCCCGGAGTTCCTGCGGGTCCCGGCGCTGGCGCCGGCG
GACCTGGAGCGGATCTTCGAGGTCGAGGGCTGGGACCGCTTCGAGGCGGCCCGCGCGCGGGGGAAGGGCGTCATCGCCTG
CACCGGGCACTTCGGCAACTTCGAGGTGCTCGCCGCCGCCATGACCCTGCGCGGCGTGCCCATCACCATGATCACGCGCC
CCATGGGCAAGTCGGGCGCCAACGACGCCTGGCGCAAGGCGCGCGAGCGGGCCGGGGTGGAGGACCTGGTGGTCCGGCGC
GGCCAGACGCTCCAGGCCGCCACCCGCTCGCTCAAGGCGGGCCGCGTGCTCGGCTACGTCATCGACCAGAACCAGCCGCG
CCGGCGCGCCGTCTTCCCCACCTTCTTCGGCGTGCCGGCGGCCACCGCGCCCACGCCGGCGGTGCTGGCCATGCGCACCG
GGGCGGCGGTGGTGTTCACGGTGTCGCTGCCGCTCGGCGACGGCCGGCACAAGGTGATCATCGAGGGCCCCATCGACCCG
CCCGACACCGGCGATCGCGACCGGGACGTGCTCGCGTTCCTGCAGGACCTGAACGACCGGTTGGAGCGGTACGTCCGCCT
GCACCCGGATCGCTGGTACTGGCTGCACCGACGGTGGAAGACGCGGCCGGACGGCGAGGGGGCCGGGAGCGCGGGCGCGG
TGGCCTGA

Upstream 100 bases:

>100_bases
TCCTGCGCGGCGCCGACGTCCTCGAGGCCGCGCTCGACGCGGCGCTCGCCGCCGCCGCCCCTCAACCCCGACCGGCGCCG
CGCGCCCCGGTGTCCTGATC

Downstream 100 bases:

>100_bases
CGCATCGTCGCGCCGCCGGCGCGCGCGTGTAGGGCACGCGGGCACCCGGCGCGGGCGGCGCGGCGGCGAGGTGCGCGATT
GACGGGCGAAACCCGCGCGC

Product: lipid A biosynthesis acyltransferase

Products: NA

Alternate protein names: Heat shock protein B [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MRLLGWIFARLPYRWIMALGAALGALVWGLGIRRRVVLENLRLAFPDRPEAERRAIARTTYRNLGQMIPEFLRVPALAPA
DLERIFEVEGWDRFEAARARGKGVIACTGHFGNFEVLAAAMTLRGVPITMITRPMGKSGANDAWRKARERAGVEDLVVRR
GQTLQAATRSLKAGRVLGYVIDQNQPRRRAVFPTFFGVPAATAPTPAVLAMRTGAAVVFTVSLPLGDGRHKVIIEGPIDP
PDTGDRDRDVLAFLQDLNDRLERYVRLHPDRWYWLHRRWKTRPDGEGAGSAGAVA

Sequences:

>Translated_295_residues
MRLLGWIFARLPYRWIMALGAALGALVWGLGIRRRVVLENLRLAFPDRPEAERRAIARTTYRNLGQMIPEFLRVPALAPA
DLERIFEVEGWDRFEAARARGKGVIACTGHFGNFEVLAAAMTLRGVPITMITRPMGKSGANDAWRKARERAGVEDLVVRR
GQTLQAATRSLKAGRVLGYVIDQNQPRRRAVFPTFFGVPAATAPTPAVLAMRTGAAVVFTVSLPLGDGRHKVIIEGPIDP
PDTGDRDRDVLAFLQDLNDRLERYVRLHPDRWYWLHRRWKTRPDGEGAGSAGAVA
>Mature_295_residues
MRLLGWIFARLPYRWIMALGAALGALVWGLGIRRRVVLENLRLAFPDRPEAERRAIARTTYRNLGQMIPEFLRVPALAPA
DLERIFEVEGWDRFEAARARGKGVIACTGHFGNFEVLAAAMTLRGVPITMITRPMGKSGANDAWRKARERAGVEDLVVRR
GQTLQAATRSLKAGRVLGYVIDQNQPRRRAVFPTFFGVPAATAPTPAVLAMRTGAAVVFTVSLPLGDGRHKVIIEGPIDP
PDTGDRDRDVLAFLQDLNDRLERYVRLHPDRWYWLHRRWKTRPDGEGAGSAGAVA

Specific function: Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA. Has 10 fold selectivity for lauroyl- ACP over myristoyl-ACP [H]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI1787292, Length=284, Percent_Identity=28.169014084507, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082094, Length=286, Percent_Identity=26.2237762237762, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788161, Length=259, Percent_Identity=25.4826254826255, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: 2.3.1.-

Molecular weight: Translated: 32892; Mature: 32892

Theoretical pI: Translated: 11.55; Mature: 11.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLGWIFARLPYRWIMALGAALGALVWGLGIRRRVVLENLRLAFPDRPEAERRAIARTT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YRNLGQMIPEFLRVPALAPADLERIFEVEGWDRFEAARARGKGVIACTGHFGNFEVLAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHH
MTLRGVPITMITRPMGKSGANDAWRKARERAGVEDLVVRRGQTLQAATRSLKAGRVLGYV
HHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCEEEEE
IDQNQPRRRAVFPTFFGVPAATAPTPAVLAMRTGAAVVFTVSLPLGDGRHKVIIEGPIDP
ECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCC
PDTGDRDRDVLAFLQDLNDRLERYVRLHPDRWYWLHRRWKTRPDGEGAGSAGAVA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLLGWIFARLPYRWIMALGAALGALVWGLGIRRRVVLENLRLAFPDRPEAERRAIARTT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
YRNLGQMIPEFLRVPALAPADLERIFEVEGWDRFEAARARGKGVIACTGHFGNFEVLAAA
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHCCCEEEEEECCCCCHHHHHHH
MTLRGVPITMITRPMGKSGANDAWRKARERAGVEDLVVRRGQTLQAATRSLKAGRVLGYV
HHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHCCCEEEEE
IDQNQPRRRAVFPTFFGVPAATAPTPAVLAMRTGAAVVFTVSLPLGDGRHKVIIEGPIDP
ECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCC
PDTGDRDRDVLAFLQDLNDRLERYVRLHPDRWYWLHRRWKTRPDGEGAGSAGAVA
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]