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The map label for this gene is gmk [H]

Identifier: 220917886

GI number: 220917886

Start: 3082199

End: 3082876

Strand: Reverse

Name: gmk [H]

Synonym: A2cp1_2787

Alternate gene names: 220917886

Gene position: 3082876-3082199 (Counterclockwise)

Preceding gene: 220917887

Following gene: 220917885

Centisome position: 61.3

GC content: 76.84

Gene sequence:

>678_bases
ATGTCGAGTGACGCCGCGCACGAGCGGCTCCCGGGGCTGCTGCTGGTGCTCTCGGCGCCGTCGGGGGCGGGGAAGACCAC
GCTCGCGCACCGGCTGCGGGACGCCTCGCCCGACGCCGTGTTCTCGATCTCGGCCACCACCCGCGCCCCGCGCGGCGCCG
AGCGCGAGGGCGTGGACTACCACTTCGTCACCGCGGAGCGGTTTGCCGATCTGGTGGCGCAGGGCGCGTTCGCGGAGTGG
GCCGAGGTGCACGGCCAGCGCTACGGCACGCTGCGCGCCACGGTGGAGCAGGCGCTCGCCGCCGGGAAGCTCGCGCTGTT
CGACATCGACGTGCAGGGCGGCGCGCAGATCAAGGCGGCGTGGCCGCAGCAGGCCGCCACCGTGCTCGTGCTGCCGCCGG
ACCAGGCGGAGCTGGAGCGGCGGCTGCGAGGGCGCGACACCGACAGCGACGAGACGATCCGCCGCCGGCTGGTGGCGGCG
CGCGCCGAGGTCGCGCGCGGCCTCGGCTCGTACGACTACGTGGTGGTGAACGACGTGCTGGAGGGCGCCCTCGCGCAGCT
CCAGGCGATCGTGCGGCACGAGCGGCTGCGCCACGCCGGGCGGTGGGATCCGGAGGCCGCGCGGGTGGCCGAGGCCTGCC
GCCGCAGCGCCGCGCCGCTCGGCGGCTGGGCGTCCTAG

Upstream 100 bases:

>100_bases
GAGACGAACACCATCGGCTCGAAGTCGCAGAGCGCCGAGGTAGCCGGCATCGTGGTGGCGCTCAAGGCGGAGATCGAGCG
CATGCGCGAGCAGGTGCAGA

Downstream 100 bases:

>100_bases
CGGGCCACGAGGCCACGCCGATCGGCGGGCGCGGATTCCGGTTGACGGCCGCCGGGGGCGAGGGTAGAAGTCGCGCCCCG
TCGGACGAGGGGCCGGGAAG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MSSDAAHERLPGLLLVLSAPSGAGKTTLAHRLRDASPDAVFSISATTRAPRGAEREGVDYHFVTAERFADLVAQGAFAEW
AEVHGQRYGTLRATVEQALAAGKLALFDIDVQGGAQIKAAWPQQAATVLVLPPDQAELERRLRGRDTDSDETIRRRLVAA
RAEVARGLGSYDYVVVNDVLEGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS

Sequences:

>Translated_225_residues
MSSDAAHERLPGLLLVLSAPSGAGKTTLAHRLRDASPDAVFSISATTRAPRGAEREGVDYHFVTAERFADLVAQGAFAEW
AEVHGQRYGTLRATVEQALAAGKLALFDIDVQGGAQIKAAWPQQAATVLVLPPDQAELERRLRGRDTDSDETIRRRLVAA
RAEVARGLGSYDYVVVNDVLEGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS
>Mature_224_residues
SSDAAHERLPGLLLVLSAPSGAGKTTLAHRLRDASPDAVFSISATTRAPRGAEREGVDYHFVTAERFADLVAQGAFAEWA
EVHGQRYGTLRATVEQALAAGKLALFDIDVQGGAQIKAAWPQQAATVLVLPPDQAELERRLRGRDTDSDETIRRRLVAAR
AEVARGLGSYDYVVVNDVLEGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=183, Percent_Identity=41.5300546448087, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4504221, Length=183, Percent_Identity=41.5300546448087, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI226874831, Length=183, Percent_Identity=41.5300546448087, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI262118259, Length=184, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262118263, Length=184, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262118255, Length=184, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4505237, Length=184, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI14780902, Length=204, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI38570142, Length=194, Percent_Identity=27.8350515463918, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI52630447, Length=201, Percent_Identity=30.3482587064677, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI21389483, Length=188, Percent_Identity=28.1914893617021, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=45.7446808510638, Blast_Score=160, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=35.1063829787234, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=35.1063829787234, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=40.4371584699454, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21356141, Length=185, Percent_Identity=38.3783783783784, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI116007136, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI85724806, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45554481, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45554489, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640542, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161077626, Length=192, Percent_Identity=30.2083333333333, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24249; Mature: 24118

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDAAHERLPGLLLVLSAPSGAGKTTLAHRLRDASPDAVFSISATTRAPRGAEREGVDY
CCCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCE
HFVTAERFADLVAQGAFAEWAEVHGQRYGTLRATVEQALAAGKLALFDIDVQGGAQIKAA
EEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEC
WPQQAATVLVLPPDQAELERRLRGRDTDSDETIRRRLVAARAEVARGLGSYDYVVVNDVL
CCCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SSDAAHERLPGLLLVLSAPSGAGKTTLAHRLRDASPDAVFSISATTRAPRGAEREGVDY
CCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCE
HFVTAERFADLVAQGAFAEWAEVHGQRYGTLRATVEQALAAGKLALFDIDVQGGAQIKAA
EEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEC
WPQQAATVLVLPPDQAELERRLRGRDTDSDETIRRRLVAARAEVARGLGSYDYVVVNDVL
CCCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EGALAQLQAIVRHERLRHAGRWDPEAARVAEACRRSAAPLGGWAS
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA