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The map label for this gene is xapA [C]

Identifier: 220917885

GI number: 220917885

Start: 3075187

End: 3076068

Strand: Reverse

Name: xapA [C]

Synonym: A2cp1_2786

Alternate gene names: 220917885

Gene position: 3076068-3075187 (Counterclockwise)

Preceding gene: 220917886

Following gene: 220917868

Centisome position: 61.16

GC content: 72.56

Gene sequence:

>882_bases
ATGGCGCGCGCGATGGTCGGGGTGATCGGGGGGACGGGGCTGGGCGAGGCGCTGGGTGCCCTCGGCGGCGGCGAGGTCCG
CGCGCTGGACACGCCCTTCGGCAGGCCCTCCGCGCCGATCACGCTGACCGAGGTGGGCGGGGTGCCGGTGGCGCTCCTCC
CGCGGCACGGGGAGGGGCACATGCTCAACCCGTCGCAGGTCCCGTACCGCGCCAACATCTGGGCGCTGAAGTCGCTGGGC
GTCACGCACGTGCTCGCGAGCGGCGCCGTCGGCAGCCTCCGCGAGGAGGTCGCGCCGCGCAACCTGGTGATCCCGGACCA
GGTCATCGACAAGACCTTCCGCCGCGCCGGCACCTTCTTCGACGACCTCGCGGTCCACGTGGAGTTCGCGGCGCCGTTCT
GCACCACCCTCCGCAACGTCCTCGTGAAGGCGGGCACCGGGTTCCCGGCGCGCGTGCACCAGGGCGGGACCTACGTCTGC
ATGGAGGGCCCGCAGTTCTCGACTCGGGCCGAGAGCGAGCTGCACCGGAGCTGGGGCGCGTCGCTCATCGGGATGACGGT
GATGCCGGAGGCGAAGCTCGCCCGCGAGGCCGAGCTCTGCTACGCGCTCGTGGCGCTCCCGACCGACTACGACTGCTGGA
AGCCGCACCCGGCCTCGGTGGACCAGGCGAAGCTCATCGAGGAGATCCTGGCGAACGTGAAGTCCGCCACGCAGAACGCG
ATCGAGCTGATCCGGCGGGCGATCCCGCACGTCGCCGCGCTCGAGAAGCCGTGCGCGTGCCAGTCGGCGCTGGCGCTCGC
GATCTGGTCGGATCGCAGCCGGATCGCGCCGGCCACCCGCGAGAAGCTCCGCCCCATCCTGGAGAAGTACCTGGCCGGCT
GA

Upstream 100 bases:

>100_bases
CGACCGCCGGCGCGGTCCGGCGGGCTGAACGACGCCCGGCGCGGTGGGCCGGCCGGGTATACTCGCCCTTTCGCCGCAGC
CCGCGGCGACGGAGGGAACG

Downstream 100 bases:

>100_bases
GCCGGGCCGGTCAGGCGCCGGTGGCGGGGGGCTCCGGCGAACGGGGCCGGCGCAGCAGCTCCGCGACCCGCGCCAGATCC
GCCACCAGGCCCGCGAGCGC

Product: methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MARAMVGVIGGTGLGEALGALGGGEVRALDTPFGRPSAPITLTEVGGVPVALLPRHGEGHMLNPSQVPYRANIWALKSLG
VTHVLASGAVGSLREEVAPRNLVIPDQVIDKTFRRAGTFFDDLAVHVEFAAPFCTTLRNVLVKAGTGFPARVHQGGTYVC
MEGPQFSTRAESELHRSWGASLIGMTVMPEAKLAREAELCYALVALPTDYDCWKPHPASVDQAKLIEEILANVKSATQNA
IELIRRAIPHVAALEKPCACQSALALAIWSDRSRIAPATREKLRPILEKYLAG

Sequences:

>Translated_293_residues
MARAMVGVIGGTGLGEALGALGGGEVRALDTPFGRPSAPITLTEVGGVPVALLPRHGEGHMLNPSQVPYRANIWALKSLG
VTHVLASGAVGSLREEVAPRNLVIPDQVIDKTFRRAGTFFDDLAVHVEFAAPFCTTLRNVLVKAGTGFPARVHQGGTYVC
MEGPQFSTRAESELHRSWGASLIGMTVMPEAKLAREAELCYALVALPTDYDCWKPHPASVDQAKLIEEILANVKSATQNA
IELIRRAIPHVAALEKPCACQSALALAIWSDRSRIAPATREKLRPILEKYLAG
>Mature_292_residues
ARAMVGVIGGTGLGEALGALGGGEVRALDTPFGRPSAPITLTEVGGVPVALLPRHGEGHMLNPSQVPYRANIWALKSLGV
THVLASGAVGSLREEVAPRNLVIPDQVIDKTFRRAGTFFDDLAVHVEFAAPFCTTLRNVLVKAGTGFPARVHQGGTYVCM
EGPQFSTRAESELHRSWGASLIGMTVMPEAKLAREAELCYALVALPTDYDCWKPHPASVDQAKLIEEILANVKSATQNAI
ELIRRAIPHVAALEKPCACQSALALAIWSDRSRIAPATREKLRPILEKYLAG

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=256, Percent_Identity=43.75, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71980569, Length=245, Percent_Identity=43.265306122449, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6323045, Length=308, Percent_Identity=35.0649350649351, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=40.2930402930403, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI221459247, Length=259, Percent_Identity=37.8378378378378, Blast_Score=168, Evalue=4e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 31313; Mature: 31181

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAMVGVIGGTGLGEALGALGGGEVRALDTPFGRPSAPITLTEVGGVPVALLPRHGEGH
CCCCEEEECCCCCHHHHHHCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCCC
MLNPSQVPYRANIWALKSLGVTHVLASGAVGSLREEVAPRNLVIPDQVIDKTFRRAGTFF
CCCCCCCCCCCCHHHHHHCCHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
DDLAVHVEFAAPFCTTLRNVLVKAGTGFPARVHQGGTYVCMEGPQFSTRAESELHRSWGA
HHHHEEEEHHCHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCCCCHHHHHHHHHHHCC
SLIGMTVMPEAKLAREAELCYALVALPTDYDCWKPHPASVDQAKLIEEILANVKSATQNA
HHHCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IELIRRAIPHVAALEKPCACQSALALAIWSDRSRIAPATREKLRPILEKYLAG
HHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ARAMVGVIGGTGLGEALGALGGGEVRALDTPFGRPSAPITLTEVGGVPVALLPRHGEGH
CCCEEEECCCCCHHHHHHCCCCCCEEEECCCCCCCCCCEEEEECCCCCEEEECCCCCCC
MLNPSQVPYRANIWALKSLGVTHVLASGAVGSLREEVAPRNLVIPDQVIDKTFRRAGTFF
CCCCCCCCCCCCHHHHHHCCHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHH
DDLAVHVEFAAPFCTTLRNVLVKAGTGFPARVHQGGTYVCMEGPQFSTRAESELHRSWGA
HHHHEEEEHHCHHHHHHHHHHHHCCCCCCCEEECCCEEEEECCCCCCHHHHHHHHHHHCC
SLIGMTVMPEAKLAREAELCYALVALPTDYDCWKPHPASVDQAKLIEEILANVKSATQNA
HHHCEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IELIRRAIPHVAALEKPCACQSALALAIWSDRSRIAPATREKLRPILEKYLAG
HHHHHHHHHHHHHHCCCCHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]