Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 220917728

GI number: 220917728

Start: 2903795

End: 2905246

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2629

Alternate gene names: 220917728

Gene position: 2905246-2903795 (Counterclockwise)

Preceding gene: 220917729

Following gene: 220917720

Centisome position: 57.77

GC content: 72.04

Gene sequence:

>1452_bases
ATGCCGAATGTGGGCGCCCGGCCGGGCAAGGAACGGATCCTGGTGGTGGACGACGAGCAGAACGCTCGCGTCGCGCTTCG
GACCATCCTGAGCGAGGAGGGGTACGAGATCGCCGAGGCCGCGGACGGCGAGGAGGCCCTGGCGCTGCTCCCCGGGTTCG
CGCCGGCGGCGGTGCTCGCCGACGTGCGGATGCCCCGCATGGACGGCATCAACCTGCTGCGCCGCGCGCGCGAGCAGGGC
TCCGACGCGGTGTTCGTGATGATGACCGCGTTCGCGAGCGTCGAGGCCGCCGTCGAGGCGATGCGCGCCGGCGCCGAGAA
CTACCTCGTCAAGCCGCTCGACGTGAACGCGGTCCTGGTGGTGCTGGAGAAGGCGCTCGAGAAGCTGCGCCTCCAGCGCG
ACACCGCGAACCTGCGCGAGCGCGTGCGCGAGCGGTACCGGTTCCACAACATCGTCGGCGACGCGCCCGAGCTGCACGCG
GTCTACGAGGTGGTGAAGCGCGCCGCGCCCACCCGCGCCACCGTCCTGATCCTGGGCGAGTCGGGCACCGGCAAGGAGCT
CTTCGCGCAGGCGCTGCACGAGGAGTCGCCGCGGGCCGACAAGGCCTTCATCAAGGTGAACTGCGCGGCGCTCTCCGAGA
CGCTGCTCGAGTCCGAGCTGTTCGGCCACGAGAAGGGCGCGTTCACCGGGGCCATCGGCCGCAAGGAGGGGCGGTTCGAG
CTCGCCGACGGCGGCACGCTGTTCCTGGACGAGATCGGCGACATCTCGCCGGCGCTCCAGATCAAGCTGCTCCGCGTGCT
CCAGCAGCGGGAGTTCGAGCGCGTCGGCGGGACGCAGACGCTCAAGGTGGACGTGCGCCTGGTCGCCGCCACCAACCGCG
ACCTCGCCGCCGAGGTGAAGAACGGGCGGTTCCGCGAGGACCTCTACTACCGGCTGAACGTGGTGGCGGTGACGCTGCCG
CCGCTGCGCCAGCGCAAGGGCGACATCCCGGCGCTGGTGAGCCACTTCATCGACAAGTACTCGAAGGCGTACGGCAAGGA
CATCCGCGGCCTCGCGCCCGGCACGCTCAACGCGGTGCTGAGCCACGACTGGCCCGGCAACGTGCGCGAGCTGGAGAACG
TGGTGGAGCGCGCGGTGGTGCTCTGCAAGGGCTCGGAGCTCACCGCCGACGACCTGCCGCCCACGCTGCGCGGCCCGCGC
CCGCGCGAGCGCGCGCCGGGCGCGCTCATCCCGGGCGCGACGCTCTACGAGATCGAGCGCGAGGCCATCCTGCGCACGCT
CGAGATGGTCGGCGGCTCCACCTCGCGCGCGGCCGAGATCCTCGGGATCAGCGTCCGCAAGATCCAGTACCGGCTGAAGG
AGTACGCCGCGGGCGGCCGGGAGGGCGGGGCCGGGCACGACCACTCCCACGACGGCGAGCACGAGCCCGAGAAGGCCGGC
GGGATGGAGTAG

Upstream 100 bases:

>100_bases
CTCAGCACTTGGCCTCGGGTAGTCACTGGACCTCGAGGCGAGAATGGTGCATAACCTGCGGACCGACGCAGGCTTTGCGC
AGGTCAGGAGCAGCATGAGC

Downstream 100 bases:

>100_bases
GGCGCGGCGCCGCGCGCGCTCACTGCGCGCGCGGGAGCCGCAGCACGAAGCGCGCGCCGCCCTCCGGGCTGTCCTCGATC
CGGATGGTGCCCCCGTGCTG

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MPNVGARPGKERILVVDDEQNARVALRTILSEEGYEIAEAADGEEALALLPGFAPAAVLADVRMPRMDGINLLRRAREQG
SDAVFVMMTAFASVEAAVEAMRAGAENYLVKPLDVNAVLVVLEKALEKLRLQRDTANLRERVRERYRFHNIVGDAPELHA
VYEVVKRAAPTRATVLILGESGTGKELFAQALHEESPRADKAFIKVNCAALSETLLESELFGHEKGAFTGAIGRKEGRFE
LADGGTLFLDEIGDISPALQIKLLRVLQQREFERVGGTQTLKVDVRLVAATNRDLAAEVKNGRFREDLYYRLNVVAVTLP
PLRQRKGDIPALVSHFIDKYSKAYGKDIRGLAPGTLNAVLSHDWPGNVRELENVVERAVVLCKGSELTADDLPPTLRGPR
PRERAPGALIPGATLYEIEREAILRTLEMVGGSTSRAAEILGISVRKIQYRLKEYAAGGREGGAGHDHSHDGEHEPEKAG
GME

Sequences:

>Translated_483_residues
MPNVGARPGKERILVVDDEQNARVALRTILSEEGYEIAEAADGEEALALLPGFAPAAVLADVRMPRMDGINLLRRAREQG
SDAVFVMMTAFASVEAAVEAMRAGAENYLVKPLDVNAVLVVLEKALEKLRLQRDTANLRERVRERYRFHNIVGDAPELHA
VYEVVKRAAPTRATVLILGESGTGKELFAQALHEESPRADKAFIKVNCAALSETLLESELFGHEKGAFTGAIGRKEGRFE
LADGGTLFLDEIGDISPALQIKLLRVLQQREFERVGGTQTLKVDVRLVAATNRDLAAEVKNGRFREDLYYRLNVVAVTLP
PLRQRKGDIPALVSHFIDKYSKAYGKDIRGLAPGTLNAVLSHDWPGNVRELENVVERAVVLCKGSELTADDLPPTLRGPR
PRERAPGALIPGATLYEIEREAILRTLEMVGGSTSRAAEILGISVRKIQYRLKEYAAGGREGGAGHDHSHDGEHEPEKAG
GME
>Mature_482_residues
PNVGARPGKERILVVDDEQNARVALRTILSEEGYEIAEAADGEEALALLPGFAPAAVLADVRMPRMDGINLLRRAREQGS
DAVFVMMTAFASVEAAVEAMRAGAENYLVKPLDVNAVLVVLEKALEKLRLQRDTANLRERVRERYRFHNIVGDAPELHAV
YEVVKRAAPTRATVLILGESGTGKELFAQALHEESPRADKAFIKVNCAALSETLLESELFGHEKGAFTGAIGRKEGRFEL
ADGGTLFLDEIGDISPALQIKLLRVLQQREFERVGGTQTLKVDVRLVAATNRDLAAEVKNGRFREDLYYRLNVVAVTLPP
LRQRKGDIPALVSHFIDKYSKAYGKDIRGLAPGTLNAVLSHDWPGNVRELENVVERAVVLCKGSELTADDLPPTLRGPRP
RERAPGALIPGATLYEIEREAILRTLEMVGGSTSRAAEILGISVRKIQYRLKEYAAGGREGGAGHDHSHDGEHEPEKAGG
ME

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=449, Percent_Identity=46.7706013363029, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1790437, Length=442, Percent_Identity=47.5113122171946, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1790299, Length=381, Percent_Identity=44.6194225721785, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1788905, Length=380, Percent_Identity=41.3157894736842, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI87082117, Length=258, Percent_Identity=52.7131782945737, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=47.5728155339806, Blast_Score=264, Evalue=9e-72,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=41.0094637223975, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI87082152, Length=236, Percent_Identity=50.4237288135593, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87081872, Length=317, Percent_Identity=44.4794952681388, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1786524, Length=342, Percent_Identity=39.4736842105263, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1787583, Length=319, Percent_Identity=40.4388714733542, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081858, Length=311, Percent_Identity=31.8327974276527, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=36.5461847389558, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1787487, Length=107, Percent_Identity=38.3177570093458, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=38.0165289256198, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=34.9593495934959, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787375, Length=108, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790863, Length=137, Percent_Identity=28.4671532846715, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52849; Mature: 52718

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNVGARPGKERILVVDDEQNARVALRTILSEEGYEIAEAADGEEALALLPGFAPAAVLA
CCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHCCCCCHHHHHH
DVRMPRMDGINLLRRAREQGSDAVFVMMTAFASVEAAVEAMRAGAENYLVKPLDVNAVLV
HCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHH
VLEKALEKLRLQRDTANLRERVRERYRFHNIVGDAPELHAVYEVVKRAAPTRATVLILGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
SGTGKELFAQALHEESPRADKAFIKVNCAALSETLLESELFGHEKGAFTGAIGRKEGRFE
CCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEE
LADGGTLFLDEIGDISPALQIKLLRVLQQREFERVGGTQTLKVDVRLVAATNRDLAAEVK
ECCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHH
NGRFREDLYYRLNVVAVTLPPLRQRKGDIPALVSHFIDKYSKAYGKDIRGLAPGTLNAVL
CCCHHHHHHEEEEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
SHDWPGNVRELENVVERAVVLCKGSELTADDLPPTLRGPRPRERAPGALIPGATLYEIER
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EAILRTLEMVGGSTSRAAEILGISVRKIQYRLKEYAAGGREGGAGHDHSHDGEHEPEKAG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCC
GME
CCC
>Mature Secondary Structure 
PNVGARPGKERILVVDDEQNARVALRTILSEEGYEIAEAADGEEALALLPGFAPAAVLA
CCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCHHHCCCCCHHHHHCCCCCHHHHHH
DVRMPRMDGINLLRRAREQGSDAVFVMMTAFASVEAAVEAMRAGAENYLVKPLDVNAVLV
HCCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHH
VLEKALEKLRLQRDTANLRERVRERYRFHNIVGDAPELHAVYEVVKRAAPTRATVLILGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEC
SGTGKELFAQALHEESPRADKAFIKVNCAALSETLLESELFGHEKGAFTGAIGRKEGRFE
CCCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCEE
LADGGTLFLDEIGDISPALQIKLLRVLQQREFERVGGTQTLKVDVRLVAATNRDLAAEVK
ECCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCHHHHHH
NGRFREDLYYRLNVVAVTLPPLRQRKGDIPALVSHFIDKYSKAYGKDIRGLAPGTLNAVL
CCCHHHHHHEEEEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
SHDWPGNVRELENVVERAVVLCKGSELTADDLPPTLRGPRPRERAPGALIPGATLYEIER
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EAILRTLEMVGGSTSRAAEILGISVRKIQYRLKEYAAGGREGGAGHDHSHDGEHEPEKAG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCC
GME
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]