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The map label for this gene is moeA [H]

Identifier: 220917720

GI number: 220917720

Start: 2896862

End: 2898031

Strand: Reverse

Name: moeA [H]

Synonym: A2cp1_2621

Alternate gene names: 220917720

Gene position: 2898031-2896862 (Counterclockwise)

Preceding gene: 220917728

Following gene: 220917719

Centisome position: 57.62

GC content: 80.94

Gene sequence:

>1170_bases
ATGGACAGGCTCCTCCGCATCCGCGACGGCATCCTCGCCGCGCTGCTCCCGGTCGGCGCCGAGGACGTTCCCTCCGAGGA
GGCGCTCGGCCGCTGGCTCGCGTCCCCCGCGCTGGCGAGCGTTCCGGCCCCGCCGCACACGTGCGCCGCCATGGACGGCT
ACGCGGTGCGCGCGGGCGACGTGACCGGGCCGGCCGTGCTCCCGGTCCGGCAGACGATCTACGCCGGCGACGTGCCCGCC
GCGGCGCTCGCCCCCGGCGAGGCGGCGCGCATCTTCACCGGCGCGACGGTGCCCCAGGGCGCGGACGCGGTGGTGCGCGA
GGAGGCGACGCGCGAGGAGGGCGGCGGGGTCCGCTTCCTCGAGGCGGCGCGCCGCGGCGAGCACGTGCGCCAGGCCGGCG
AGGACGTGCCCGCCGGCGGGCTGGCGCTCGCGGCCGGCGTTCGCGTCGGCCCGCGGCAGGCGGCGCTGCTCCGGGCGGTG
GGCGGGCCGGTCGTGTCGGTGCGCCGTCGGCCGCGGGTGGCGGTGCTCTCCACCGGCGATGAGGTCGTGTCCGGCCGCAC
GCCGGACTCGAACGGCGAGGCGGTGGCGGGGCTGGTCCGCGCGCTGGGCGCGGAGGTCGAGCGGCGGCCGGTGCCGGACC
GGCTCGAGGCGGTGGTCGCCGCGATCCGCGACGCGCTCGCGAGCGCCGACGCGGCGGTGACCATCGGCGGGGTGTCGATC
GGCGCGCGCGACCTCGTCCCGGAGGCGCTCGCGCACCTGCAGGCCGACGTGCGCGTGCACGGCGTGCCCATGAAGCCGGG
GAAGCCGTTCCTGTTCGCGCTCGCCGGCGGCGCGCCGGTGCTGGGGCTGCCGGGCAGCCCGTCGGCGTGCCTGGTCGCGT
TCGAGGTGTTCGCGCGCCCGGCGCTGCTGGCGCTGTGCGGCGCGGCCCGGACCGAGCGGCGCGTGGTCCCGCTGCGGCTG
GCCGCGCCGGCGGAGGGGCGGCCGGGCCGGGCGCGGCTGCTGTGGGCCGCCGTGGAGCCCGGCGGGCGCGCGCGGCCGCT
GGGCCGCGACTCGGCGCAGGTGCGCGGGCCGGCGCTCGCCGACGCGCTGCTGTTCGTGCCCGCCGACGCCGGCGACCTGC
CGGAGGGCGCGGAGGTGGCGGCGTGGCTGCTCGAGGACTGCGCAGGGTGA

Upstream 100 bases:

>100_bases
CGCCGCAGACGTTGCGTTTTGGCCCGGATCAATACTCGCTCTGCGCACCTTTTGCGATCGGGCCGCCGCGGCCCCGGTAC
GTGGCATGATGCGGTCCACG

Downstream 100 bases:

>100_bases
CGCGGCGGGCGCCGCCCATCGTGGCGGTGAGCGGGCCGAGCGGCGTCGGGAAGACCCGGCTGCTGCGCCGGCTCGTGGCG
GAGCTGGCCCGGCGCGGCCT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDRLLRIRDGILAALLPVGAEDVPSEEALGRWLASPALASVPAPPHTCAAMDGYAVRAGDVTGPAVLPVRQTIYAGDVPA
AALAPGEAARIFTGATVPQGADAVVREEATREEGGGVRFLEAARRGEHVRQAGEDVPAGGLALAAGVRVGPRQAALLRAV
GGPVVSVRRRPRVAVLSTGDEVVSGRTPDSNGEAVAGLVRALGAEVERRPVPDRLEAVVAAIRDALASADAAVTIGGVSI
GARDLVPEALAHLQADVRVHGVPMKPGKPFLFALAGGAPVLGLPGSPSACLVAFEVFARPALLALCGAARTERRVVPLRL
AAPAEGRPGRARLLWAAVEPGGRARPLGRDSAQVRGPALADALLFVPADAGDLPEGAEVAAWLLEDCAG

Sequences:

>Translated_389_residues
MDRLLRIRDGILAALLPVGAEDVPSEEALGRWLASPALASVPAPPHTCAAMDGYAVRAGDVTGPAVLPVRQTIYAGDVPA
AALAPGEAARIFTGATVPQGADAVVREEATREEGGGVRFLEAARRGEHVRQAGEDVPAGGLALAAGVRVGPRQAALLRAV
GGPVVSVRRRPRVAVLSTGDEVVSGRTPDSNGEAVAGLVRALGAEVERRPVPDRLEAVVAAIRDALASADAAVTIGGVSI
GARDLVPEALAHLQADVRVHGVPMKPGKPFLFALAGGAPVLGLPGSPSACLVAFEVFARPALLALCGAARTERRVVPLRL
AAPAEGRPGRARLLWAAVEPGGRARPLGRDSAQVRGPALADALLFVPADAGDLPEGAEVAAWLLEDCAG
>Mature_389_residues
MDRLLRIRDGILAALLPVGAEDVPSEEALGRWLASPALASVPAPPHTCAAMDGYAVRAGDVTGPAVLPVRQTIYAGDVPA
AALAPGEAARIFTGATVPQGADAVVREEATREEGGGVRFLEAARRGEHVRQAGEDVPAGGLALAAGVRVGPRQAALLRAV
GGPVVSVRRRPRVAVLSTGDEVVSGRTPDSNGEAVAGLVRALGAEVERRPVPDRLEAVVAAIRDALASADAAVTIGGVSI
GARDLVPEALAHLQADVRVHGVPMKPGKPFLFALAGGAPVLGLPGSPSACLVAFEVFARPALLALCGAARTERRVVPLRL
AAPAEGRPGRARLLWAAVEPGGRARPLGRDSAQVRGPALADALLFVPADAGDLPEGAEVAAWLLEDCAG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=376, Percent_Identity=32.4468085106383, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI10880983, Length=376, Percent_Identity=32.4468085106383, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1787049, Length=335, Percent_Identity=34.0298507462687, Blast_Score=157, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI25147659, Length=317, Percent_Identity=31.8611987381703, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=335, Percent_Identity=25.3731343283582, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136978, Length=371, Percent_Identity=29.3800539083558, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24638841, Length=371, Percent_Identity=29.3800539083558, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 39551; Mature: 39551

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLLRIRDGILAALLPVGAEDVPSEEALGRWLASPALASVPAPPHTCAAMDGYAVRAGD
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCHHHHCCCCEEEECC
VTGPAVLPVRQTIYAGDVPAAALAPGEAARIFTGATVPQGADAVVREEATREEGGGVRFL
CCCCEEEHHHHHHCCCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHH
EAARRGEHVRQAGEDVPAGGLALAAGVRVGPRQAALLRAVGGPVVSVRRRPRVAVLSTGD
HHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEECCC
EVVSGRTPDSNGEAVAGLVRALGAEVERRPVPDRLEAVVAAIRDALASADAAVTIGGVSI
HHHCCCCCCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
GARDLVPEALAHLQADVRVHGVPMKPGKPFLFALAGGAPVLGLPGSPSACLVAFEVFARP
CHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHHH
ALLALCGAARTERRVVPLRLAAPAEGRPGRARLLWAAVEPGGRARPLGRDSAQVRGPALA
HHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHH
DALLFVPADAGDLPEGAEVAAWLLEDCAG
CEEEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRLLRIRDGILAALLPVGAEDVPSEEALGRWLASPALASVPAPPHTCAAMDGYAVRAGD
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCHHHHCCCCEEEECC
VTGPAVLPVRQTIYAGDVPAAALAPGEAARIFTGATVPQGADAVVREEATREEGGGVRFL
CCCCEEEHHHHHHCCCCCCHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCHHH
EAARRGEHVRQAGEDVPAGGLALAAGVRVGPRQAALLRAVGGPVVSVRRRPRVAVLSTGD
HHHHHHHHHHHCCCCCCCCCEEHHCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEECCC
EVVSGRTPDSNGEAVAGLVRALGAEVERRPVPDRLEAVVAAIRDALASADAAVTIGGVSI
HHHCCCCCCCCCHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCC
GARDLVPEALAHLQADVRVHGVPMKPGKPFLFALAGGAPVLGLPGSPSACLVAFEVFARP
CHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHHHH
ALLALCGAARTERRVVPLRLAAPAEGRPGRARLLWAAVEPGGRARPLGRDSAQVRGPALA
HHHHHHHCCCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHH
DALLFVPADAGDLPEGAEVAAWLLEDCAG
CEEEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8682795; 11759840 [H]