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The map label for this gene is alsR [H]

Identifier: 220916839

GI number: 220916839

Start: 1937132

End: 1938022

Strand: Direct

Name: alsR [H]

Synonym: A2cp1_1735

Alternate gene names: 220916839

Gene position: 1937132-1938022 (Clockwise)

Preceding gene: 220916837

Following gene: 220916845

Centisome position: 38.52

GC content: 78.45

Gene sequence:

>891_bases
ATGGAGCTCCGGCACCTGCGGTACTTCGTGGCGGTCGCGGAGGAGCTGCACTTCGGCCGCGCCGCCGCGCGGCTCGGGAT
CGCGCAGCCGCCGCTCAGCCAGCAGATCCGCCAGCTCGAGCGCGAGCTCGGCGTCGAGCTGTTCCTGCGGGCCCGCCGAC
GCGTCGAGCTCACCGAGCCGGGGCGGGTGCTGCTCGGGCACGCGCGCGCCGTCCTGCAGCGCGCGTCGCAGGCGGCGGAG
GACGTCCGGCGGGCGGCGCGGGGCGAGACCGGGGCCCTCTCGGTGGGCGTGGTGGCGTCCGCCACCTATGGCGTCGTGCC
GCGCGTGTTTCGCACGTTCCGCGCTCGCCACCCCGACGTGGCGCTCGGCGTGGCGGTGATGAGCACCGGCGCGCAGGTGG
CCGCGCTCCGGGCCGGGCAGCTCGACCTCGGGCTGGCGCGCACGCCGTTCGGGGACGAGACGCTGGTGGCCGAGACCGTG
CTGGAGGAGCCGGTGGTGGTGGCGCTGCCGGCGGGGCACCCGCTCTCGGCGCGCCGCGCGCTGCGCCTGGCGGCGCTGGC
GCCAGAGCCGTTCGTCCTGTTCCCGCGCGACCGCCGGCCGGGCTGGTACGACTTCGTGCTGGGGCTGTGCCGCGAGGCCG
GCTTCCGGCCCCGGGTGGCCGAGGACGCCCCCGAGCTCGCCACCGCCATGGCGCTGGTGGCGGCGGGGATCGGGGTGACG
CTGGTGCCGGCGTCGGTGAAGGACCTGCGGCGGAGCGGGGTGGACTACCGCCCCATCGCCGCGCCGCGGGCGCGCACGCG
CCTGGTGGCGCTGCGCCGCCCCGGCGAGCCGTCGCCGCTGGTGGTCCGCTTCGTCGAGGTGGTGCGCGAGGTGCTCCGCC
GCGGCGGGTAG

Upstream 100 bases:

>100_bases
GCGCGCGGCCTCGGGCATGGGCCCGGGAACATGCGGAAGGACCGTCGAGACGTCCAATATATCTTTGCTCTCGTGTCGAG
ACCTCGTAGATCTCGATGGC

Downstream 100 bases:

>100_bases
CCGGCGGGCGGCGCCGCCTCAGGTCGCGTACTGCGCCTCGCCGTTCCCGAAGGACCAGTTCTCCTTCGCCACCTCGACCA
GGCTGACGATGACGTCCTCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MELRHLRYFVAVAEELHFGRAAARLGIAQPPLSQQIRQLERELGVELFLRARRRVELTEPGRVLLGHARAVLQRASQAAE
DVRRAARGETGALSVGVVASATYGVVPRVFRTFRARHPDVALGVAVMSTGAQVAALRAGQLDLGLARTPFGDETLVAETV
LEEPVVVALPAGHPLSARRALRLAALAPEPFVLFPRDRRPGWYDFVLGLCREAGFRPRVAEDAPELATAMALVAAGIGVT
LVPASVKDLRRSGVDYRPIAAPRARTRLVALRRPGEPSPLVVRFVEVVREVLRRGG

Sequences:

>Translated_296_residues
MELRHLRYFVAVAEELHFGRAAARLGIAQPPLSQQIRQLERELGVELFLRARRRVELTEPGRVLLGHARAVLQRASQAAE
DVRRAARGETGALSVGVVASATYGVVPRVFRTFRARHPDVALGVAVMSTGAQVAALRAGQLDLGLARTPFGDETLVAETV
LEEPVVVALPAGHPLSARRALRLAALAPEPFVLFPRDRRPGWYDFVLGLCREAGFRPRVAEDAPELATAMALVAAGIGVT
LVPASVKDLRRSGVDYRPIAAPRARTRLVALRRPGEPSPLVVRFVEVVREVLRRGG
>Mature_296_residues
MELRHLRYFVAVAEELHFGRAAARLGIAQPPLSQQIRQLERELGVELFLRARRRVELTEPGRVLLGHARAVLQRASQAAE
DVRRAARGETGALSVGVVASATYGVVPRVFRTFRARHPDVALGVAVMSTGAQVAALRAGQLDLGLARTPFGDETLVAETV
LEEPVVVALPAGHPLSARRALRLAALAPEPFVLFPRDRRPGWYDFVLGLCREAGFRPRVAEDAPELATAMALVAAGIGVT
LVPASVKDLRRSGVDYRPIAAPRARTRLVALRRPGEPSPLVVRFVEVVREVLRRGG

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=286, Percent_Identity=41.6083916083916, Blast_Score=201, Evalue=3e-53,
Organism=Escherichia coli, GI1788887, Length=290, Percent_Identity=35.8620689655172, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI2367136, Length=264, Percent_Identity=38.6363636363636, Blast_Score=167, Evalue=5e-43,
Organism=Escherichia coli, GI1790399, Length=279, Percent_Identity=31.8996415770609, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI157672245, Length=272, Percent_Identity=31.6176470588235, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87081904, Length=202, Percent_Identity=32.6732673267327, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI145693105, Length=255, Percent_Identity=23.5294117647059, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787601, Length=299, Percent_Identity=25.0836120401338, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790208, Length=285, Percent_Identity=28.7719298245614, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=26.0330578512397, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1789204, Length=284, Percent_Identity=28.8732394366197, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788297, Length=250, Percent_Identity=27.2, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=25.8964143426295, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788296, Length=202, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787806, Length=286, Percent_Identity=25.5244755244755, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790262, Length=294, Percent_Identity=25.5102040816327, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788626, Length=262, Percent_Identity=31.2977099236641, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788481, Length=247, Percent_Identity=28.3400809716599, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787589, Length=125, Percent_Identity=34.4, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994962, Length=146, Percent_Identity=31.5068493150685, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=119, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786401, Length=143, Percent_Identity=29.3706293706294, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32157; Mature: 32157

Theoretical pI: Translated: 11.80; Mature: 11.80

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLRYFVAVAEELHFGRAAARLGIAQPPLSQQIRQLERELGVELFLRARRRVELTEP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GRVLLGHARAVLQRASQAAEDVRRAARGETGALSVGVVASATYGVVPRVFRTFRARHPDV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCH
ALGVAVMSTGAQVAALRAGQLDLGLARTPFGDETLVAETVLEEPVVVALPAGHPLSARRA
HHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHH
LRLAALAPEPFVLFPRDRRPGWYDFVLGLCREAGFRPRVAEDAPELATAMALVAAGIGVT
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
LVPASVKDLRRSGVDYRPIAAPRARTRLVALRRPGEPSPLVVRFVEVVREVLRRGG
EECHHHHHHHHCCCCCCCCCCCHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MELRHLRYFVAVAEELHFGRAAARLGIAQPPLSQQIRQLERELGVELFLRARRRVELTEP
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GRVLLGHARAVLQRASQAAEDVRRAARGETGALSVGVVASATYGVVPRVFRTFRARHPDV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCH
ALGVAVMSTGAQVAALRAGQLDLGLARTPFGDETLVAETVLEEPVVVALPAGHPLSARRA
HHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHH
LRLAALAPEPFVLFPRDRRPGWYDFVLGLCREAGFRPRVAEDAPELATAMALVAAGIGVT
HHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCE
LVPASVKDLRRSGVDYRPIAAPRARTRLVALRRPGEPSPLVVRFVEVVREVLRRGG
EECHHHHHHHHCCCCCCCCCCCHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]