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The map label for this gene is merA [H]

Identifier: 220916845

GI number: 220916845

Start: 1943737

End: 1945116

Strand: Direct

Name: merA [H]

Synonym: A2cp1_1741

Alternate gene names: 220916845

Gene position: 1943737-1945116 (Clockwise)

Preceding gene: 220916839

Following gene: 220916846

Centisome position: 38.65

GC content: 78.19

Gene sequence:

>1380_bases
ATGGCAACGGATCTCGACGTGCTGGTCCTCGGCTCCGGCCAGGCCGGCGTGCCGCTCGCGGCGCGGCTCGCCGCCGCGGG
GCGGCGGGTGGCGCTGGTCGAGCGCGGCGACCTGGGTGGCACCTGCGTGAACGCCGGCTGCACGCCGACGAAGACGCTCA
TCGCGAGCGCGCGCGCCGCGCACGTGGCGAGGACCGCCGGGCGGCTCGGGATCCGCGCCGGCGAGGTGCAGGTGGACCTC
GGGGCGGCGATGGACCGCAAGGACGCGGTGGTGGCGCGCTGGCGCGAGGGCGTGCGCCAGCGGCTGGAGGCCGCCGCGCC
GCGGCTGCGGCTGGTGCACGGCCCCGCGCGCTTCGTGGCCCCGCGCGAGGTGGAGGTCGCGGGCGAGCGGCTCGCGGCGC
CGGTGGTGATCGTGAACGTGGGCGCGCGGCCGGCGGTGGCGCCCGTCCCCGGGCTGGACCGGGTCCCGTTCCTCACCAGC
ACGGGCGCGCTCGCGCTGCGGGCGCTCCCCGCGCACCTGGTGGTGCTCGGCGGCGGCTACGTCGGCTGCGAGCTCGCGCA
GCTGTTCCGGCGGTTCGGCGCCGGCGTGACGGTGATCGACCCCTCGCCGCACCTGCTCGCCCGCGAGGACGAGGCGGTGA
GCGCCGCGCTGGAGGAGGTGTTCCGGCGCGAGGGCATCCGGCTCGCGCTGGGCGCGGCGGCCGAGGCGGTCGAGGGCGGC
GCGGGTGCGGTGCGGGTGCGGCTCGCGGGCGGCGCGGTGGAGGAGGGCTCGCACCTGCTCGTCGCCACCGGACGCCGCCC
GAACACCGACGACCTCGGCTGCGACGCGGCCGGCGTGGCGCTGGATCGCCGCGGGTTCGTGGAGGTGGACGCGCGCTACT
GCACCAGCGCCGAGGGCGTGTACGCGGTGGGCGACGCGGCCGGCGGCCCGCAGTTCACCCACAGCGCCTGGGACGACCAC
CGCATCCTGTTCGACCTCCTGCTCGGCCGCGGCCGGCGGACGCGCGACGACCGGCTGGTGCCGCACGTGGTGTTCACCGA
TCCGCAGGTCGGGGTGGTCGGGCTGACCGAGCGGGAGGCGCGGGCGCGCGGCGTCCCGTTCGAGCTCGCCACGCTGCCGT
ACTCGGCGGTGGCGCGCGCCGTCGAGGTGGACGAGCCGGACGGGGTCGTGCGCGTGCTGGTGGACCCGCGCGACGAGCGG
ATCCTGGGCGCGGCGGTGGTGGGGGCGGAGGGAGGGGAGCTCGTGCACGTCCTCGCCGCGCTGATGCAGGCGGGCGCGAG
CGCGCGGGCGCTCGTGGACATGGAGATGGCCCACCCGACGTTCTGCGAGGGGCTCCAGTCCGCGGTGATGACGCTCGAGC
GCTTCGCGCTGCGGCCCTGA

Upstream 100 bases:

>100_bases
GAGGCGTCTTCTCGGGCGCGCGACACCTGGGAGCGGCCTGGCGCGGGCGCCCCGGCGGCGGCAGATCCGCGGGACGCCCA
CGCGGGCGCGGAGGTGGCGC

Downstream 100 bases:

>100_bases
TCGGAGCCCCTCGGGCGCGGCCGTTTCGCCCCGCGCAACGATCCGGTGCGCCCCCGGACATTGCGCCGGACCGGGCCGGC
CGGCACATCCCGGGGCAGGA

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation subunit

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MATDLDVLVLGSGQAGVPLAARLAAAGRRVALVERGDLGGTCVNAGCTPTKTLIASARAAHVARTAGRLGIRAGEVQVDL
GAAMDRKDAVVARWREGVRQRLEAAAPRLRLVHGPARFVAPREVEVAGERLAAPVVIVNVGARPAVAPVPGLDRVPFLTS
TGALALRALPAHLVVLGGGYVGCELAQLFRRFGAGVTVIDPSPHLLAREDEAVSAALEEVFRREGIRLALGAAAEAVEGG
AGAVRVRLAGGAVEEGSHLLVATGRRPNTDDLGCDAAGVALDRRGFVEVDARYCTSAEGVYAVGDAAGGPQFTHSAWDDH
RILFDLLLGRGRRTRDDRLVPHVVFTDPQVGVVGLTEREARARGVPFELATLPYSAVARAVEVDEPDGVVRVLVDPRDER
ILGAAVVGAEGGELVHVLAALMQAGASARALVDMEMAHPTFCEGLQSAVMTLERFALRP

Sequences:

>Translated_459_residues
MATDLDVLVLGSGQAGVPLAARLAAAGRRVALVERGDLGGTCVNAGCTPTKTLIASARAAHVARTAGRLGIRAGEVQVDL
GAAMDRKDAVVARWREGVRQRLEAAAPRLRLVHGPARFVAPREVEVAGERLAAPVVIVNVGARPAVAPVPGLDRVPFLTS
TGALALRALPAHLVVLGGGYVGCELAQLFRRFGAGVTVIDPSPHLLAREDEAVSAALEEVFRREGIRLALGAAAEAVEGG
AGAVRVRLAGGAVEEGSHLLVATGRRPNTDDLGCDAAGVALDRRGFVEVDARYCTSAEGVYAVGDAAGGPQFTHSAWDDH
RILFDLLLGRGRRTRDDRLVPHVVFTDPQVGVVGLTEREARARGVPFELATLPYSAVARAVEVDEPDGVVRVLVDPRDER
ILGAAVVGAEGGELVHVLAALMQAGASARALVDMEMAHPTFCEGLQSAVMTLERFALRP
>Mature_458_residues
ATDLDVLVLGSGQAGVPLAARLAAAGRRVALVERGDLGGTCVNAGCTPTKTLIASARAAHVARTAGRLGIRAGEVQVDLG
AAMDRKDAVVARWREGVRQRLEAAAPRLRLVHGPARFVAPREVEVAGERLAAPVVIVNVGARPAVAPVPGLDRVPFLTST
GALALRALPAHLVVLGGGYVGCELAQLFRRFGAGVTVIDPSPHLLAREDEAVSAALEEVFRREGIRLALGAAAEAVEGGA
GAVRVRLAGGAVEEGSHLLVATGRRPNTDDLGCDAAGVALDRRGFVEVDARYCTSAEGVYAVGDAAGGPQFTHSAWDDHR
ILFDLLLGRGRRTRDDRLVPHVVFTDPQVGVVGLTEREARARGVPFELATLPYSAVARAVEVDEPDGVVRVLVDPRDERI
LGAAVVGAEGGELVHVLAALMQAGASARALVDMEMAHPTFCEGLQSAVMTLERFALRP

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=462, Percent_Identity=30.3030303030303, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=26.9565217391304, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI291045266, Length=424, Percent_Identity=25, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI33519430, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33519428, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI33519426, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI148277071, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI148277065, Length=440, Percent_Identity=24.3181818181818, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI22035672, Length=456, Percent_Identity=28.0701754385965, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=35.3982300884956, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1786307, Length=470, Percent_Identity=30, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082354, Length=468, Percent_Identity=27.7777777777778, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=29.4930875576037, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1789065, Length=193, Percent_Identity=30.5699481865285, Blast_Score=62, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=31.0195227765727, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=28.0254777070064, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=448, Percent_Identity=27.2321428571429, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=448, Percent_Identity=27.2321428571429, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=447, Percent_Identity=23.9373601789709, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17559934, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=469, Percent_Identity=28.997867803838, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6325240, Length=472, Percent_Identity=26.9067796610169, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=470, Percent_Identity=25.531914893617, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21358499, Length=459, Percent_Identity=33.1154684095861, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24640553, Length=496, Percent_Identity=26.8145161290323, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24640549, Length=496, Percent_Identity=26.8145161290323, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24640551, Length=496, Percent_Identity=26.8145161290323, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17737741, Length=490, Percent_Identity=27.5510204081633, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 47908; Mature: 47776

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATDLDVLVLGSGQAGVPLAARLAAAGRRVALVERGDLGGTCVNAGCTPTKTLIASARAA
CCCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
HVARTAGRLGIRAGEVQVDLGAAMDRKDAVVARWREGVRQRLEAAAPRLRLVHGPARFVA
HHHHHHHHCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
PREVEVAGERLAAPVVIVNVGARPAVAPVPGLDRVPFLTSTGALALRALPAHLVVLGGGY
CCHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHCCEEEEEECCCH
VGCELAQLFRRFGAGVTVIDPSPHLLAREDEAVSAALEEVFRREGIRLALGAAAEAVEGG
HHHHHHHHHHHHCCCEEEECCCCCEEECCHHHHHHHHHHHHHHCCCEEEECCHHHHHCCC
AGAVRVRLAGGAVEEGSHLLVATGRRPNTDDLGCDAAGVALDRRGFVEVDARYCTSAEGV
CCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCEEECHHHCCCCCCE
YAVGDAAGGPQFTHSAWDDHRILFDLLLGRGRRTRDDRLVPHVVFTDPQVGVVGLTEREA
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEECCCHHH
RARGVPFELATLPYSAVARAVEVDEPDGVVRVLVDPRDERILGAAVVGAEGGELVHVLAA
HHCCCCEEEECCCHHHHHHEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHH
LMQAGASARALVDMEMAHPTFCEGLQSAVMTLERFALRP
HHHCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATDLDVLVLGSGQAGVPLAARLAAAGRRVALVERGDLGGTCVNAGCTPTKTLIASARAA
CCCEEEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
HVARTAGRLGIRAGEVQVDLGAAMDRKDAVVARWREGVRQRLEAAAPRLRLVHGPARFVA
HHHHHHHHCCEEECEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHCC
PREVEVAGERLAAPVVIVNVGARPAVAPVPGLDRVPFLTSTGALALRALPAHLVVLGGGY
CCHHHHCCHHHCCCEEEEECCCCCCCCCCCCCCCCCEEECCCHHHHHHCCEEEEEECCCH
VGCELAQLFRRFGAGVTVIDPSPHLLAREDEAVSAALEEVFRREGIRLALGAAAEAVEGG
HHHHHHHHHHHHCCCEEEECCCCCEEECCHHHHHHHHHHHHHHCCCEEEECCHHHHHCCC
AGAVRVRLAGGAVEEGSHLLVATGRRPNTDDLGCDAAGVALDRRGFVEVDARYCTSAEGV
CCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCCEEECHHHCCCCCCE
YAVGDAAGGPQFTHSAWDDHRILFDLLLGRGRRTRDDRLVPHVVFTDPQVGVVGLTEREA
EEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCEEECCCHHH
RARGVPFELATLPYSAVARAVEVDEPDGVVRVLVDPRDERILGAAVVGAEGGELVHVLAA
HHCCCCEEEECCCHHHHHHEEECCCCCCEEEEEECCCCCCEEEEEEECCCCCHHHHHHHH
LMQAGASARALVDMEMAHPTFCEGLQSAVMTLERFALRP
HHHCCCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037534 [H]