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The map label for this gene is zraS [H]

Identifier: 220904834

GI number: 220904834

Start: 1883844

End: 1885547

Strand: Reverse

Name: zraS [H]

Synonym: Ddes_1567

Alternate gene names: 220904834

Gene position: 1885547-1883844 (Counterclockwise)

Preceding gene: 220904835

Following gene: 220904833

Centisome position: 65.62

GC content: 55.11

Gene sequence:

>1704_bases
ATGTCCGCAGTCGCTCCCGCGCCCCATCGCGGGTACAAGGTCATCTATCGCCGCCTGCTCGTTACGCTGCTGCTTATGGC
GCTCACGCCGCTGGTGGCTCTGGGGCTGTTCTGCCTGGACAGGCTGAGCGCCATCTATGACGAAAAGATCAGCGCGGGCA
TCGAGGCTGTAGCCAGCAGCAAACACCGCGCGCTGGATACATTTATGGTGGAGCGCATCGCCCAGATAAAAAATCTGGCC
TTCACCCATCCTTATGCAGAATTGAGCAATTCCGCGCGTCTGAGCGATATCTTCAGCATCATGCAGAACAACAGCCGCTC
CTTTGTGGATGTGGGTGTCATCGGCATGGACGGCCGCCATGTCTCCTATGTGGGACCATATGACCTCAGCGACAACAATT
ACTCCGACACTCCCTGGTTCAGAGAGGTGCTGCGCAAGGGTGTGTATGTGAGTGATGTGTTTATGGGCTACAGGAACGAG
CCTCATTTCATCATAGCGGTGCTGCGGCACGAGGGGGGGCGCAGCTACATAGTACGGGCTACCATTGATATGGACGCTAT
GGGGGCCTTGCTGCGTCGCGTGTATTCCGGTCCGCACAGCGATGCCTTTCTGGTCAATGCCAGAGGCGAGCTCCAGACGG
ATTCGCGCTATCACGGCAAAAGCATGGCGCGGTTTGGTGTGCCACTGCCGGATATGACCCGCAAAAATGTGTCCACCCAG
CATCTGACCACATCCAAAGGGCAGGAAATGCTGGCCGCCATGATGCCTCTGGAGTCCATGCCCTGGGCGCTTGTGGTGCT
TGATGATGTGCGTGACAGCCTCCAACCGTTACGGCAACTCAAAGCGCTGATTGTTTTTTTCATGATTCTGGGCAGCGGGC
TTATCTGTATGGGGGCCGAACTCTGCACCCGGCGGCTCGTGGCTTCGCTTGAAGAGTCTGACCAGAAACAGGCCCATATC
GATGCCCGCATGCTTCAGTCCAGCAAAATGGCGGCCCTTGGCAAAATGGCCGCCGGGGTGGCCCATGAGGTAAACAATCC
CCTTATGCTCATTCAGGAAAATGCGGGCTGGATACGTGACCTGCTGGACGATGAAAAACCCGAAGCAATGAAAAATTATC
AAGAAATACTGGAAAGTACAGAAAAAATTGACCAGCATGTCAAGCGCGCCAAAGGCATAACCCAGCGCATGCTCGGCTTT
GGCCGCCGCATGAACCCCGGCCGTACGGAAATACTGATCAACTCCCTGACGGATCAGGCTGCTGAAATGCTTAAAACAGA
AGCCACCAATCGCAATATTGACATTATCAGAGAGTATGATCCGCAGGTGCCGGTTATCCTGTCAGATCCCGCGCAGCTTG
AGCAGATTTTTATCAATATTATCGACAACGCCATTGATGCCATCGGCAAAAACGGCTCTCTGACCATTCGCACCCTTGCC
TGGAAGAAGGGTGTTCGCATATTGTTTACCGATAGCGGTCCCGGTATGGATCAGGAAACCGTAACCCGTATTTTTGATCC
TTTTTTTACTACCAAGAAGGTGGGCGAGGGTACGGGCCTTGGGCTGGCTATCTGTTATACCATACTTGAAAAGCTGGGCG
GCCGCATTGAGGTGCAGAGCCGGCTGGGAGAAGGAACCACCTTCAGCATAACCCTGCCCGCCGAACCGCCGCAGCTTCCG
CCGGAAGACGGTCTGCCAGCCTGA

Upstream 100 bases:

>100_bases
AGGTGGCCGCCCGGCGGGAGGAAATGCTCGAACACTGCCGTATGCTGTTCAAGGGCGAAAAATTGCCGCAGGCCGCAACC
GGCGTGGAGGAATCATAGCC

Downstream 100 bases:

>100_bases
GGCACGTACCGGCGAATGAAGTAATCTGATGATGCCGGGGGCGGCCTTGGGCCTGCCCTAACTATACGCTCCGGCGTCAC
TTGCTGCACGAGACACGTCA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSAVAPAPHRGYKVIYRRLLVTLLLMALTPLVALGLFCLDRLSAIYDEKISAGIEAVASSKHRALDTFMVERIAQIKNLA
FTHPYAELSNSARLSDIFSIMQNNSRSFVDVGVIGMDGRHVSYVGPYDLSDNNYSDTPWFREVLRKGVYVSDVFMGYRNE
PHFIIAVLRHEGGRSYIVRATIDMDAMGALLRRVYSGPHSDAFLVNARGELQTDSRYHGKSMARFGVPLPDMTRKNVSTQ
HLTTSKGQEMLAAMMPLESMPWALVVLDDVRDSLQPLRQLKALIVFFMILGSGLICMGAELCTRRLVASLEESDQKQAHI
DARMLQSSKMAALGKMAAGVAHEVNNPLMLIQENAGWIRDLLDDEKPEAMKNYQEILESTEKIDQHVKRAKGITQRMLGF
GRRMNPGRTEILINSLTDQAAEMLKTEATNRNIDIIREYDPQVPVILSDPAQLEQIFINIIDNAIDAIGKNGSLTIRTLA
WKKGVRILFTDSGPGMDQETVTRIFDPFFTTKKVGEGTGLGLAICYTILEKLGGRIEVQSRLGEGTTFSITLPAEPPQLP
PEDGLPA

Sequences:

>Translated_567_residues
MSAVAPAPHRGYKVIYRRLLVTLLLMALTPLVALGLFCLDRLSAIYDEKISAGIEAVASSKHRALDTFMVERIAQIKNLA
FTHPYAELSNSARLSDIFSIMQNNSRSFVDVGVIGMDGRHVSYVGPYDLSDNNYSDTPWFREVLRKGVYVSDVFMGYRNE
PHFIIAVLRHEGGRSYIVRATIDMDAMGALLRRVYSGPHSDAFLVNARGELQTDSRYHGKSMARFGVPLPDMTRKNVSTQ
HLTTSKGQEMLAAMMPLESMPWALVVLDDVRDSLQPLRQLKALIVFFMILGSGLICMGAELCTRRLVASLEESDQKQAHI
DARMLQSSKMAALGKMAAGVAHEVNNPLMLIQENAGWIRDLLDDEKPEAMKNYQEILESTEKIDQHVKRAKGITQRMLGF
GRRMNPGRTEILINSLTDQAAEMLKTEATNRNIDIIREYDPQVPVILSDPAQLEQIFINIIDNAIDAIGKNGSLTIRTLA
WKKGVRILFTDSGPGMDQETVTRIFDPFFTTKKVGEGTGLGLAICYTILEKLGGRIEVQSRLGEGTTFSITLPAEPPQLP
PEDGLPA
>Mature_566_residues
SAVAPAPHRGYKVIYRRLLVTLLLMALTPLVALGLFCLDRLSAIYDEKISAGIEAVASSKHRALDTFMVERIAQIKNLAF
THPYAELSNSARLSDIFSIMQNNSRSFVDVGVIGMDGRHVSYVGPYDLSDNNYSDTPWFREVLRKGVYVSDVFMGYRNEP
HFIIAVLRHEGGRSYIVRATIDMDAMGALLRRVYSGPHSDAFLVNARGELQTDSRYHGKSMARFGVPLPDMTRKNVSTQH
LTTSKGQEMLAAMMPLESMPWALVVLDDVRDSLQPLRQLKALIVFFMILGSGLICMGAELCTRRLVASLEESDQKQAHID
ARMLQSSKMAALGKMAAGVAHEVNNPLMLIQENAGWIRDLLDDEKPEAMKNYQEILESTEKIDQHVKRAKGITQRMLGFG
RRMNPGRTEILINSLTDQAAEMLKTEATNRNIDIIREYDPQVPVILSDPAQLEQIFINIIDNAIDAIGKNGSLTIRTLAW
KKGVRILFTDSGPGMDQETVTRIFDPFFTTKKVGEGTGLGLAICYTILEKLGGRIEVQSRLGEGTTFSITLPAEPPQLPP
EDGLPA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=32.2175732217573, Blast_Score=132, Evalue=8e-32,
Organism=Escherichia coli, GI1788549, Length=235, Percent_Identity=33.6170212765957, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790300, Length=250, Percent_Identity=29.2, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=284, Percent_Identity=27.8169014084507, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788393, Length=222, Percent_Identity=24.3243243243243, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=125, Percent_Identity=32.8, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=24.6696035242291, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63013; Mature: 62882

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVAPAPHRGYKVIYRRLLVTLLLMALTPLVALGLFCLDRLSAIYDEKISAGIEAVASS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHRALDTFMVERIAQIKNLAFTHPYAELSNSARLSDIFSIMQNNSRSFVDVGVIGMDGRH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCE
VSYVGPYDLSDNNYSDTPWFREVLRKGVYVSDVFMGYRNEPHFIIAVLRHEGGRSYIVRA
EEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEECCCCEEEEEE
TIDMDAMGALLRRVYSGPHSDAFLVNARGELQTDSRYHGKSMARFGVPLPDMTRKNVSTQ
EECHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCHH
HLTTSKGQEMLAAMMPLESMPWALVVLDDVRDSLQPLRQLKALIVFFMILGSGLICMGAE
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LCTRRLVASLEESDQKQAHIDARMLQSSKMAALGKMAAGVAHEVNNPLMLIQENAGWIRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
LLDDEKPEAMKNYQEILESTEKIDQHVKRAKGITQRMLGFGRRMNPGRTEILINSLTDQA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AEMLKTEATNRNIDIIREYDPQVPVILSDPAQLEQIFINIIDNAIDAIGKNGSLTIRTLA
HHHHHHHCCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
WKKGVRILFTDSGPGMDQETVTRIFDPFFTTKKVGEGTGLGLAICYTILEKLGGRIEVQS
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEHH
RLGEGTTFSITLPAEPPQLPPEDGLPA
HCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVAPAPHRGYKVIYRRLLVTLLLMALTPLVALGLFCLDRLSAIYDEKISAGIEAVASS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KHRALDTFMVERIAQIKNLAFTHPYAELSNSARLSDIFSIMQNNSRSFVDVGVIGMDGRH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCE
VSYVGPYDLSDNNYSDTPWFREVLRKGVYVSDVFMGYRNEPHFIIAVLRHEGGRSYIVRA
EEEECCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEEEECCCCEEEEEE
TIDMDAMGALLRRVYSGPHSDAFLVNARGELQTDSRYHGKSMARFGVPLPDMTRKNVSTQ
EECHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCHHCCCCHH
HLTTSKGQEMLAAMMPLESMPWALVVLDDVRDSLQPLRQLKALIVFFMILGSGLICMGAE
HHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LCTRRLVASLEESDQKQAHIDARMLQSSKMAALGKMAAGVAHEVNNPLMLIQENAGWIRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHH
LLDDEKPEAMKNYQEILESTEKIDQHVKRAKGITQRMLGFGRRMNPGRTEILINSLTDQA
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
AEMLKTEATNRNIDIIREYDPQVPVILSDPAQLEQIFINIIDNAIDAIGKNGSLTIRTLA
HHHHHHHCCCCCCEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
WKKGVRILFTDSGPGMDQETVTRIFDPFFTTKKVGEGTGLGLAICYTILEKLGGRIEVQS
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEHH
RLGEGTTFSITLPAEPPQLPPEDGLPA
HCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]