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The map label for this gene is uvrB [H]

Identifier: 220904694

GI number: 220904694

Start: 1706598

End: 1708634

Strand: Reverse

Name: uvrB [H]

Synonym: Ddes_1426

Alternate gene names: 220904694

Gene position: 1708634-1706598 (Counterclockwise)

Preceding gene: 220904696

Following gene: 220904693

Centisome position: 59.46

GC content: 56.7

Gene sequence:

>2037_bases
ATGGAAGACAAGTTAACCACCCCGTTCAGCCTGGAAACCGCCTATGCGCCTACGGGTGACCAGCCCGGGGCCATCAATGA
ACTGGTGGCCAACCTTCAGGCCGGAGTACCCGCTCAGGTGCTGCTGGGCGTTACCGGCTCGGGCAAAACGTTTACCATGG
CCAATGTCATTGCCCGTTGCAATCGCCCGGCGCTGGTGCTTGCGCCCAATAAAACCCTGGCGGCCCAGTTGTACGGTGAG
TTCCGCGCGCTTTTTCCCCACAACGCCGTAGAATATTTTGTCAGCTATTACGATTATTACCAGCCGGAAGCCTATGTGCC
TGCATCGGATACCTATATTGAGAAAGATTCTTCCATCAACGATAACATAGACAAGCTGCGCCATGCCGCCACGCATGCCC
TGCTGACCAGACGCGATGTGATCATTGTGGCCTCTGTTTCATGCATCTACGGTCTTGGTTCGCCGGAATATTACGCCAAG
ATGGTCGTTCCTGTTGAAGTGGGCCAGCATTTTTCCATGGACAGGCTCATCACGCGGTTGGTGGAAGTGCATTATGAGCG
TAATGACTATGACTTTCATCGCGGTACGTTCCGCGTGCGCGGCGATGCCCTTGAAATTATTCCGGCCTATCATCACGAAC
GCGCCCTGCGGCTGGAATTTTTTGGCGACGATATTGATTCCATGCGCGAAATAGATCCTCTCACGGGCGAGGTTCTGGCT
GATGTGAGTAAAACCGTTATCTACCCGGCCAGCCACTTCGTCTCCGCGCAGGACAATCTCAAGCGTGCCGCCGGCGACAT
TCGCGATGAACTGGCCGAGCGCCTGACCCTGTTCAGACAGCAGGGCAAGCTGGTGGAAGCCCAGCGCCTTGAGCAGCGCA
CACAGCTTGATCTTGAAATGATCGAAGAGCTTGGCTACTGCAACGGCATTGAAAACTACACCCGTCATCTGGACGGCCGT
GTGGCGGGTGAGCCGCCATCCTGCCTGCTCAACTATTTTCCTGAGGATTTTCTTCTTTTTGTGGACGAATCGCATATCAC
TATCCCCCAGGTGGGGGGCATGTACAAAGGCGACCGCTCACGCAAGCAGACGCTGGTTGACTACGGTTTTCGCTTGCCTT
CCGCTCTGGATAACCGCCCCCTGCAATTCAACGAATTTACGGCGCTGCTCAATCAGGTGGTTTACGTGTCGGCCACCCCC
GGAAAATACGAAATGGATCAGGCCCAGGGCATTGTGGCCGAGCAGATCATTCGCCCCACAGGCCTTGTGGACCCTATGGT
GGAAGTGCGCCCCACCAAGGGGCAGATGGAAGACCTGCTTGGCGAATGCCGGGGCTGCGTGAGCCGGGGCGAAAGGGTGC
TTGTGACTACCCTGACCAAACGCATGGCCGAAGATCTTACAGAGTACTGCTGCAATATGGGAGTGCGGGCGCGCTACCTG
CACTCGGATATTGATACCCTTGAGCGCATGCAGATCATCCGTGCCCTGCGCCTGGGCGAGTTCGACGTGCTGGTGGGCAT
CAACCTGCTGCGTGAAGGACTGGATATTCCCGAAGTTTCCCTGGTCTGCATTCTGGATGCGGACAAGGAAGGTTTCTTGC
GTTCCACCGGTTCGCTTATCCAGACATTTGGCCGCGCAGCCCGTAACGTTCAGGGGCGGGTCATCCTGTATGCCGACAAG
GTAACGGACTCTATGAAGGCCGCCATGAGCGAAACGGCGCGCCGCCGTACCCGGCAGACAGAGTATAATGAAGAACACGG
CATAACACCTGTAAGTACAAGAAAAAGCCTTGAATCCCCGCTGGATAGTTTGTATGTGGAAGATGGCGCCTCACGCGGGC
GCGGCAAGGGGCGGGGTAAGAGCAAAGGGCAGGATGCGGACGCAAGCCCGCTTACGGCCGAAGACACGGCCCTGCTGGTG
GCCAGGCTTGAAAAGGAAATGCGCCAGGCTGCCCGTGATCTGGAGTTTGAACAGGCGGCACAATTGCGTGACCGCATCCG
CGTCTTGCGGGCGCGTCTTATTGCATTACCGGATTAA

Upstream 100 bases:

>100_bases
CCAGCGGCAGGTCGAACTGCGTGGGTACAAGGATTGTTTCCATAGCACTTCCCGTTGTTAGTGTATTATTTCACACCCTC
TTACCCCAAAACGGAATATG

Downstream 100 bases:

>100_bases
GAGCCGGGTGTGCAACTTGGCTGCGCGTTTACCACATCCCCAATGCTGTCGGTTTGCCAGCTTTTGCAACGATACATCCC
CAATTTGACACGTTCCAGTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MEDKLTTPFSLETAYAPTGDQPGAINELVANLQAGVPAQVLLGVTGSGKTFTMANVIARCNRPALVLAPNKTLAAQLYGE
FRALFPHNAVEYFVSYYDYYQPEAYVPASDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIVASVSCIYGLGSPEYYAK
MVVPVEVGQHFSMDRLITRLVEVHYERNDYDFHRGTFRVRGDALEIIPAYHHERALRLEFFGDDIDSMREIDPLTGEVLA
DVSKTVIYPASHFVSAQDNLKRAAGDIRDELAERLTLFRQQGKLVEAQRLEQRTQLDLEMIEELGYCNGIENYTRHLDGR
VAGEPPSCLLNYFPEDFLLFVDESHITIPQVGGMYKGDRSRKQTLVDYGFRLPSALDNRPLQFNEFTALLNQVVYVSATP
GKYEMDQAQGIVAEQIIRPTGLVDPMVEVRPTKGQMEDLLGECRGCVSRGERVLVTTLTKRMAEDLTEYCCNMGVRARYL
HSDIDTLERMQIIRALRLGEFDVLVGINLLREGLDIPEVSLVCILDADKEGFLRSTGSLIQTFGRAARNVQGRVILYADK
VTDSMKAAMSETARRRTRQTEYNEEHGITPVSTRKSLESPLDSLYVEDGASRGRGKGRGKSKGQDADASPLTAEDTALLV
ARLEKEMRQAARDLEFEQAAQLRDRIRVLRARLIALPD

Sequences:

>Translated_678_residues
MEDKLTTPFSLETAYAPTGDQPGAINELVANLQAGVPAQVLLGVTGSGKTFTMANVIARCNRPALVLAPNKTLAAQLYGE
FRALFPHNAVEYFVSYYDYYQPEAYVPASDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIVASVSCIYGLGSPEYYAK
MVVPVEVGQHFSMDRLITRLVEVHYERNDYDFHRGTFRVRGDALEIIPAYHHERALRLEFFGDDIDSMREIDPLTGEVLA
DVSKTVIYPASHFVSAQDNLKRAAGDIRDELAERLTLFRQQGKLVEAQRLEQRTQLDLEMIEELGYCNGIENYTRHLDGR
VAGEPPSCLLNYFPEDFLLFVDESHITIPQVGGMYKGDRSRKQTLVDYGFRLPSALDNRPLQFNEFTALLNQVVYVSATP
GKYEMDQAQGIVAEQIIRPTGLVDPMVEVRPTKGQMEDLLGECRGCVSRGERVLVTTLTKRMAEDLTEYCCNMGVRARYL
HSDIDTLERMQIIRALRLGEFDVLVGINLLREGLDIPEVSLVCILDADKEGFLRSTGSLIQTFGRAARNVQGRVILYADK
VTDSMKAAMSETARRRTRQTEYNEEHGITPVSTRKSLESPLDSLYVEDGASRGRGKGRGKSKGQDADASPLTAEDTALLV
ARLEKEMRQAARDLEFEQAAQLRDRIRVLRARLIALPD
>Mature_678_residues
MEDKLTTPFSLETAYAPTGDQPGAINELVANLQAGVPAQVLLGVTGSGKTFTMANVIARCNRPALVLAPNKTLAAQLYGE
FRALFPHNAVEYFVSYYDYYQPEAYVPASDTYIEKDSSINDNIDKLRHAATHALLTRRDVIIVASVSCIYGLGSPEYYAK
MVVPVEVGQHFSMDRLITRLVEVHYERNDYDFHRGTFRVRGDALEIIPAYHHERALRLEFFGDDIDSMREIDPLTGEVLA
DVSKTVIYPASHFVSAQDNLKRAAGDIRDELAERLTLFRQQGKLVEAQRLEQRTQLDLEMIEELGYCNGIENYTRHLDGR
VAGEPPSCLLNYFPEDFLLFVDESHITIPQVGGMYKGDRSRKQTLVDYGFRLPSALDNRPLQFNEFTALLNQVVYVSATP
GKYEMDQAQGIVAEQIIRPTGLVDPMVEVRPTKGQMEDLLGECRGCVSRGERVLVTTLTKRMAEDLTEYCCNMGVRARYL
HSDIDTLERMQIIRALRLGEFDVLVGINLLREGLDIPEVSLVCILDADKEGFLRSTGSLIQTFGRAARNVQGRVILYADK
VTDSMKAAMSETARRRTRQTEYNEEHGITPVSTRKSLESPLDSLYVEDGASRGRGKGRGKSKGQDADASPLTAEDTALLV
ARLEKEMRQAARDLEFEQAAQLRDRIRVLRARLIALPD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=674, Percent_Identity=58.7537091988131, Blast_Score=793, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76066; Mature: 76066

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKLTTPFSLETAYAPTGDQPGAINELVANLQAGVPAQVLLGVTGSGKTFTMANVIARC
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHC
NRPALVLAPNKTLAAQLYGEFRALFPHNAVEYFVSYYDYYQPEAYVPASDTYIEKDSSIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCC
DNIDKLRHAATHALLTRRDVIIVASVSCIYGLGSPEYYAKMVVPVEVGQHFSMDRLITRL
CCHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHEEEEEEEECCCCCCHHHHHHHH
VEVHYERNDYDFHRGTFRVRGDALEIIPAYHHERALRLEFFGDDIDSMREIDPLTGEVLA
HHHHHCCCCCCCCCCEEEECCCCEEEEECHHCCCEEEEEECCCCHHHHHHCCCCHHHHHH
DVSKTVIYPASHFVSAQDNLKRAAGDIRDELAERLTLFRQQGKLVEAQRLEQRTQLDLEM
HHHHHEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IEELGYCNGIENYTRHLDGRVAGEPPSCLLNYFPEDFLLFVDESHITIPQVGGMYKGDRS
HHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCEECCCCCCCCCCCCH
RKQTLVDYGFRLPSALDNRPLQFNEFTALLNQVVYVSATPGKYEMDQAQGIVAEQIIRPT
HHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCEEEEEECCCCCCHHHHCCHHHHHHHCCC
GLVDPMVEVRPTKGQMEDLLGECRGCVSRGERVLVTTLTKRMAEDLTEYCCNMGVRARYL
CCCCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHH
HSDIDTLERMQIIRALRLGEFDVLVGINLLREGLDIPEVSLVCILDADKEGFLRSTGSLI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHH
QTFGRAARNVQGRVILYADKVTDSMKAAMSETARRRTRQTEYNEEHGITPVSTRKSLESP
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHH
LDSLYVEDGASRGRGKGRGKSKGQDADASPLTAEDTALLVARLEKEMRQAARDLEFEQAA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
QLRDRIRVLRARLIALPD
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEDKLTTPFSLETAYAPTGDQPGAINELVANLQAGVPAQVLLGVTGSGKTFTMANVIARC
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEHHHHHHHHC
NRPALVLAPNKTLAAQLYGEFRALFPHNAVEYFVSYYDYYQPEAYVPASDTYIEKDSSIN
CCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCC
DNIDKLRHAATHALLTRRDVIIVASVSCIYGLGSPEYYAKMVVPVEVGQHFSMDRLITRL
CCHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHEEEEEEEECCCCCCHHHHHHHH
VEVHYERNDYDFHRGTFRVRGDALEIIPAYHHERALRLEFFGDDIDSMREIDPLTGEVLA
HHHHHCCCCCCCCCCEEEECCCCEEEEECHHCCCEEEEEECCCCHHHHHHCCCCHHHHHH
DVSKTVIYPASHFVSAQDNLKRAAGDIRDELAERLTLFRQQGKLVEAQRLEQRTQLDLEM
HHHHHEEECHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IEELGYCNGIENYTRHLDGRVAGEPPSCLLNYFPEDFLLFVDESHITIPQVGGMYKGDRS
HHHCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCEECCCCCCCCCCCCH
RKQTLVDYGFRLPSALDNRPLQFNEFTALLNQVVYVSATPGKYEMDQAQGIVAEQIIRPT
HHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHCEEEEEECCCCCCHHHHCCHHHHHHHCCC
GLVDPMVEVRPTKGQMEDLLGECRGCVSRGERVLVTTLTKRMAEDLTEYCCNMGVRARYL
CCCCCCCEECCCCCHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHH
HSDIDTLERMQIIRALRLGEFDVLVGINLLREGLDIPEVSLVCILDADKEGFLRSTGSLI
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHH
QTFGRAARNVQGRVILYADKVTDSMKAAMSETARRRTRQTEYNEEHGITPVSTRKSLESP
HHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCHHHHHHHHH
LDSLYVEDGASRGRGKGRGKSKGQDADASPLTAEDTALLVARLEKEMRQAARDLEFEQAA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHH
QLRDRIRVLRARLIALPD
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA