BacMap

Definition	Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774 chromosome, complete genome.
Accession	NC_011883
Length	2,873,437

Click here to switch to the map view.

The map label for this gene is gmk [H]

Identifier: 220904674

GI number: 220904674

Start: 1681356

End: 1681964

Strand: Direct

Name: gmk [H]

Synonym: Ddes_1406

Alternate gene names: 220904674

Gene position: 1681356-1681964 (Clockwise)

Preceding gene: 220904673

Following gene: 220904675

Centisome position: 58.51

GC content: 61.25

Gene sequence:

>609_bases
ATGCCCCGACAAGGCATTGCCCTGGTCTTGAGCGCCCCCTCCGGGGCTGGAAAAACGACATTGGTTCAACGCCTGCTGCG
GGCCTTCCCCCTGCTGGGCTACTCTGTTTCCTGCACCACGCGCCTGCCCCGGCAGGGCGAAGTGGACGGCAAGGACTATA
TATTCATCAGCCGTGAAGAATTTGAACAGCGCCGCGCCGAAGGCTATTTTGCCGAATGGGCCGAAGTGCACGGCAATCTT
TACGGCACGCCGCTGGCCCCGGTGAAGGAAAAACTGCGCCTTGGGCAGGACCTGCTTTTTGACATTGACGTGCAGGGCGC
CGCCCAGCTCAAGCTTTCCTTGACCGAGGCGGTCTTTGTTTTCATACTGCCGCCCGGCATGACCGAGCTTGAACGCCGCC
TGCGCAACCGGGGCCTGGATGATGAAAAAACCATTGAGCGCCGCCTGGCCAACGCCCGGCAGGAAATACTCGAAGCCCGC
TGGTATGATGCGCTTGTGGTCAATGACAACCTGGACGTGGCCTATGACGAGCTGCGCTCGGTTTTTGTGGCGGCAAGCCT
TGCCCCCGACCGCAACCCCGACCTGTCGGAAACAGTGCTGCGCGGCTGA

Upstream 100 bases:

>100_bases
AAACGCGCTCCATTCTTGTGACGGATTCCAACCACGTCATTCTTTCATCCATACAACCTGAAACCATCAGCCAGCGCTTT
GCGCAAGAGGAAGGAATCTG

Downstream 100 bases:

>100_bases
GCCGCTGCCGTACGGCAGCCATACCAGTACAGCAGGTACCTTTACTTTATTGACGCCACGAACCGGATTAAATCATGAAA
AGCGCAAATATCGCTCCACA

Product: Guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MPRQGIALVLSAPSGAGKTTLVQRLLRAFPLLGYSVSCTTRLPRQGEVDGKDYIFISREEFEQRRAEGYFAEWAEVHGNL
YGTPLAPVKEKLRLGQDLLFDIDVQGAAQLKLSLTEAVFVFILPPGMTELERRLRNRGLDDEKTIERRLANARQEILEAR
WYDALVVNDNLDVAYDELRSVFVAASLAPDRNPDLSETVLRG

Sequences:

>Translated_202_residues
MPRQGIALVLSAPSGAGKTTLVQRLLRAFPLLGYSVSCTTRLPRQGEVDGKDYIFISREEFEQRRAEGYFAEWAEVHGNL
YGTPLAPVKEKLRLGQDLLFDIDVQGAAQLKLSLTEAVFVFILPPGMTELERRLRNRGLDDEKTIERRLANARQEILEAR
WYDALVVNDNLDVAYDELRSVFVAASLAPDRNPDLSETVLRG
>Mature_201_residues
PRQGIALVLSAPSGAGKTTLVQRLLRAFPLLGYSVSCTTRLPRQGEVDGKDYIFISREEFEQRRAEGYFAEWAEVHGNLY
GTPLAPVKEKLRLGQDLLFDIDVQGAAQLKLSLTEAVFVFILPPGMTELERRLRNRGLDDEKTIERRLANARQEILEARW
YDALVVNDNLDVAYDELRSVFVAASLAPDRNPDLSETVLRG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=40.9090909090909, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI226874833, Length=176, Percent_Identity=40.9090909090909, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI4504221, Length=176, Percent_Identity=40.9090909090909, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI21361598, Length=204, Percent_Identity=29.9019607843137, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=32.183908045977, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI111154074, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI262118259, Length=188, Percent_Identity=28.1914893617021, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118255, Length=188, Percent_Identity=28.1914893617021, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4505237, Length=188, Percent_Identity=28.1914893617021, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118263, Length=188, Percent_Identity=28.1914893617021, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI52630447, Length=187, Percent_Identity=28.3422459893048, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI119943106, Length=170, Percent_Identity=27.6470588235294, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI21389483, Length=176, Percent_Identity=30.1136363636364, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI148539628, Length=172, Percent_Identity=30.8139534883721, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI148539578, Length=172, Percent_Identity=30.8139534883721, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI119943108, Length=160, Percent_Identity=28.125, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI261862237, Length=170, Percent_Identity=27.6470588235294, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI14780902, Length=197, Percent_Identity=26.9035532994924, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI186700627, Length=191, Percent_Identity=24.0837696335079, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI186700629, Length=191, Percent_Identity=24.0837696335079, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI186972120, Length=191, Percent_Identity=24.0837696335079, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI218156340, Length=173, Percent_Identity=30.635838150289, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI218156270, Length=177, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI218156338, Length=172, Percent_Identity=30.8139534883721, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=44.5026178010471, Blast_Score=161, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=37.5, Blast_Score=123, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=37.5, Blast_Score=123, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17557440, Length=186, Percent_Identity=23.6559139784946, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=181, Percent_Identity=43.0939226519337, Blast_Score=156, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21356141, Length=180, Percent_Identity=42.2222222222222, Blast_Score=136, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45554489, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45554481, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24640542, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI116007136, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI85724806, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161077626, Length=175, Percent_Identity=30.8571428571429, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI161077752, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554804, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161077754, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554813, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45554791, Length=167, Percent_Identity=31.1377245508982, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221330166, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330162, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330164, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816281, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551002, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85816106, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281360700, Length=177, Percent_Identity=30.5084745762712, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641280, Length=177, Percent_Identity=30.5084745762712, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641282, Length=177, Percent_Identity=30.5084745762712, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI45554818, Length=177, Percent_Identity=30.5084745762712, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22718; Mature: 22587

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRQGIALVLSAPSGAGKTTLVQRLLRAFPLLGYSVSCTTRLPRQGEVDGKDYIFISREE
CCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHH
FEQRRAEGYFAEWAEVHGNLYGTPLAPVKEKLRLGQDLLFDIDVQGAAQLKLSLTEAVFV
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHEEEEHHHEEEE
FILPPGMTELERRLRNRGLDDEKTIERRLANARQEILEARWYDALVVNDNLDVAYDELRS
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHH
VFVAASLAPDRNPDLSETVLRG
HHHHHHCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
PRQGIALVLSAPSGAGKTTLVQRLLRAFPLLGYSVSCTTRLPRQGEVDGKDYIFISREE
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEEHHH
FEQRRAEGYFAEWAEVHGNLYGTPLAPVKEKLRLGQDLLFDIDVQGAAQLKLSLTEAVFV
HHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHEEEEHHHEEEE
FILPPGMTELERRLRNRGLDDEKTIERRLANARQEILEARWYDALVVNDNLDVAYDELRS
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHH
VFVAASLAPDRNPDLSETVLRG
HHHHHHCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA