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The map label for this gene is trxA [H]

Identifier: 220904469

GI number: 220904469

Start: 1411162

End: 1411485

Strand: Direct

Name: trxA [H]

Synonym: Ddes_1199

Alternate gene names: 220904469

Gene position: 1411162-1411485 (Clockwise)

Preceding gene: 220904468

Following gene: 220904470

Centisome position: 49.11

GC content: 54.01

Gene sequence:

>324_bases
ATGGCTGAACAGGTCACTGACGCCACCTTTGAAAGTGTTGTCCTCAAGTCCGATCTGCCGGTTCTGCTTGACTTTTGGGC
ACCCTGGTGCGGCCCCTGCCGCGCTGTTGGCCCTATCATTGACGAACTTGCCACCGAATATGCAGGCAAAGTGCGCATCG
TAAAGATGAACGTGGATGAAAATCCTGCCACTCCCACAAAATTCGGCATACGTGCTATCCCCACCCTCGTCCTTTTCAAA
AACGGCGAAACTGTCGAGCAGATCACCGGCGCTGTGACCAAGGCTGCCATGAAAGATCTGCTTGATACCAAGGCGCTGGC
ATGA

Upstream 100 bases:

>100_bases
TCAATACAGAGGCCTCGGAATCCATATCCCGAAGCTTCGGTTTTCCGCCTCTGCGCCCTTTCGGGCATGCAGTGCGCAAC
ATAAACCTAAGGAGATAGTT

Downstream 100 bases:

>100_bases
AAGCATACGATGCCGTTGTGATCGGTGGCGGCCCCGCCGGCGTTACCGCAGCCCTGTATCTGGCGCGGTCCGGTTGCAGC
GTTCTTATGCCGGAGCGTTT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAEQVTDATFESVVLKSDLPVLLDFWAPWCGPCRAVGPIIDELATEYAGKVRIVKMNVDENPATPTKFGIRAIPTLVLFK
NGETVEQITGAVTKAAMKDLLDTKALA

Sequences:

>Translated_107_residues
MAEQVTDATFESVVLKSDLPVLLDFWAPWCGPCRAVGPIIDELATEYAGKVRIVKMNVDENPATPTKFGIRAIPTLVLFK
NGETVEQITGAVTKAAMKDLLDTKALA
>Mature_106_residues
AEQVTDATFESVVLKSDLPVLLDFWAPWCGPCRAVGPIIDELATEYAGKVRIVKMNVDENPATPTKFGIRAIPTLVLFKN
GETVEQITGAVTKAAMKDLLDTKALA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=81, Percent_Identity=34.5679012345679, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI5031973, Length=96, Percent_Identity=30.2083333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=52.5252525252525, Blast_Score=127, Evalue=2e-31,
Organism=Escherichia coli, GI1788936, Length=101, Percent_Identity=49.5049504950495, Blast_Score=111, Evalue=1e-26,
Organism=Escherichia coli, GI87081747, Length=99, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=37.6344086021505, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71980562, Length=96, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=82, Percent_Identity=36.5853658536585, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=70, Percent_Identity=42.8571428571429, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=42.8571428571429, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=70, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17549970, Length=82, Percent_Identity=39.0243902439024, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=75, Percent_Identity=38.6666666666667, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=36, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=92, Percent_Identity=32.6086956521739, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=100, Percent_Identity=37, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=33.695652173913, Blast_Score=69, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=99, Percent_Identity=35.3535353535354, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=38.75, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=43.2432432432432, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=38.0281690140845, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=31.1827956989247, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11577; Mature: 11445

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQVTDATFESVVLKSDLPVLLDFWAPWCGPCRAVGPIIDELATEYAGKVRIVKMNVDE
CCCCHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPATPTKFGIRAIPTLVLFKNGETVEQITGAVTKAAMKDLLDTKALA
CCCCCCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEQVTDATFESVVLKSDLPVLLDFWAPWCGPCRAVGPIIDELATEYAGKVRIVKMNVDE
CCCHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPATPTKFGIRAIPTLVLFKNGETVEQITGAVTKAAMKDLLDTKALA
CCCCCCHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]