Click here to switch to the map view.

The map label for this gene is mutS2 [H]

Identifier: 220904359

GI number: 220904359

Start: 1274486

End: 1276939

Strand: Reverse

Name: mutS2 [H]

Synonym: Ddes_1087

Alternate gene names: 220904359

Gene position: 1276939-1274486 (Counterclockwise)

Preceding gene: 220904360

Following gene: 220904358

Centisome position: 44.44

GC content: 59.33

Gene sequence:

>2454_bases
ATGATTCACGCCCGTACGCTCCAGGCCCTGGAATATAATAATGTTACCGACTATCTTGCCTCGCTCTGTATTTCCGGCGT
GGGGCGCGATCGCGCACTGGCGCTTGCTCCGCTGCCCCAGGCCGAGGATGTAAACCTGGCGGCACGGGTCTATGAAGAGG
CGGCTGACTGGTCTTCCCGGCCTGCTGCCGGAGGGTCGATATTTATCCTTAACGCCTTTCCCGACGTCACAGGTTTTTTG
CACGCCGCACAAACCAGCCGCGGCCACGCTTTTCAGCCGGATGTGGACGCTTTCTGGGCGCTGCGTGAAGTTTTGCGTCT
GGCACGCGATGCCCACGCCGCCATTGCCGTACCCGAAGCACCAAGACAGTGGCCGCATTTGTTGGCCCTGGCCGACGGCA
CGCCTTTGCCTGTGCAGCTTACGGCGGCTCTTCTGCGCTGTCTTTCAGATGACGGCCTGCTGAAAGACGAAAGTTCGCCC
GAACTTTACCGCCTGCGCGGCGAGTTGCGCCGCCTGCATCAGGGCTGCATGCGCAAGGTCAAGGACTACGCGCTGCAGTA
CAATATGCTTGCCTATTTGCAGGACGAATTCATGACCCTTTCGTCCGACCGCTATGTGCTGCCCCTCAAGGCCAACTTCA
AGGGGCGCATGCAGGGCATCATTCACGACTGGTCGCAAACGGGCGAAACCTGCTACTTTGAACCCATGTTTCTGGTGGAA
ATCAACAACCGCCTACAAGAATTAAAACGCGAAGAGCGCGAAGAAGAACGCAAGGTTTTGCTATACCTGCGCACTTTGCT
TGAAGCAGAACTGCCTGGCGCTCAAGCTGCCCTTGAATTGCTGGCCCAGCTGGACCTGCTGCAGGCCAAACGCCGCCTGG
CAGCCCTTCTTGACGGCCGCTGCCTGCCGTTGACCCCCGTGGCCGAAGGCATACAGCTGCTCGACGCCCGCCATCCCCTG
CTCTTGCTCAACAGGGTTAAAAGCGCAGACAGCTCTGCCACGGATTCAGGGCATACCCAAAAATCCGCCGCACGGGCGGC
AGCAGCCGTAAAACCTCTTGATATCGTGCTGCGGCCTGGCGAACGCGCCCTGATTATCACAGGCGGCAATGCTGGCGGCA
AGACGGTCTGCCTGAAAACGCTGGGGCTTATCGCCGCCATGACCCTTAGTGGCCTGCCGGTTCCTGTGGGGGCTGGCTCC
CATCTGCCCTGGTTCAGCCGCATGGACGCCTTTATTGGCGACGAACAGAGTCTTGCGGACAATGTTTCTACCTTTACGGC
GCAGATCGAGCACCTTGCCAAAGCCTGGAAGCACCTTGACGCCAGCGGCATGGTGCTGCTTGATGAATTCGGCGCTGGCA
CAGACCCGGCCCAGGGCGCTGCTCTGGCCCAGGCGGTACTTGACGAATTGCTCGACAAGCATACCTTTGTACTGGCAGCC
ACACATTTTCCCGCGCTCAAGAGCTATGCCCTGACCAGGGAAGGAGCGCGCGCGGCCTCCATGCTGTTTGATCCGCAAAG
CAAAAAACCCCTGTTCAAACTGGCCTACGATCAGGTGGGGGCCAGCCAGGCCCTTGATGTGGCACGCGAACACGGGTTAC
CGGAAAGCATTGTGCGCCGTGCAGAGCATTATCTTTTGCAGGACGGACAAGATGCCACTGCCCTGCTTTCCAGGTTAAAC
GATCTGGCCGCAAAGCGCGAAGAAGAACTGGTTATTTTACGGCAGGAACAGGACAAAACCCGGTCTGCCGCCAGACACGA
GCGCGAAAAGCTGGAAAAAGAACGGTTGCGCCTGCACGATGAGGTGCGAACCAAAGCCTCCGAACTTATGCGCGCGTGGA
AAGAAGGCCGCGCAACCCACAAGCAGGCCCTGAAAGAAATGGCCCGCCTGCGGGCTTCGCTTGTTCCTGATGACACTGCG
GACAAAAGCGGTTCTGTTTTACCCATCGCTGAACATTTTGTGGTGGGCCAGCAGGTTCTGCACACTGTTTTCAATAAGCG
CGGCGTGGTCACCGATGTGGATGAGCGGCGTAACCGTGTGCGCCTCGAGATGAACGGCGTCAACCTGTGGGCCGAGATGA
AGGCCCTGCGTCTGCCCGGCAGCCAGGGAAACCCGCAGCCCGTTGGCAAGCCTTCTTCCATCTTGGCCGCAGCGCACGGC
TCGTCCTCCACAGGCGGAGGCGGCGCACGGCCCGCTGGAGCCGCCACTGGAGCCTCACTGCGCCTTGACATGCGCGGACT
TCGTGCTGATGTTGCCCTTGCAGAACTCGAGCAGTTCATGGATAAGGCTTTGCTGGCCGGTTTTCGGGAAGTCGAGGTGG
TCCACGGACGCGGTACGGGGGCTTTACGGCGCCAGGTTCATGAATTTTTGCGCACCTTTCCGGCAGTGGAAAATTTTTGT
CTGGCCCCCGAAGACAGAGGTGGCGATGGCATGACCATTGTAATCCTGCGATAG

Upstream 100 bases:

>100_bases
GGCAAAAACGCACTCTCCGGGGTACTCGGGCCTTCAGGTCCGCGGGGGGTTGCGTCCTTTTTTCTGCGACAAGCCATTTC
ATTGCTCCCGAGGCATCAGC

Downstream 100 bases:

>100_bases
TAACAGCTTACAGATAAAAAATTACCAAAAACGGATTCATCCGGCGTAATCACGGTGCAACAAAGATACCGGCAAGACCA
CGTATGCGGTACGGCAAGGC

Product: Smr protein/MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 817; Mature: 817

Protein sequence:

>817_residues
MIHARTLQALEYNNVTDYLASLCISGVGRDRALALAPLPQAEDVNLAARVYEEAADWSSRPAAGGSIFILNAFPDVTGFL
HAAQTSRGHAFQPDVDAFWALREVLRLARDAHAAIAVPEAPRQWPHLLALADGTPLPVQLTAALLRCLSDDGLLKDESSP
ELYRLRGELRRLHQGCMRKVKDYALQYNMLAYLQDEFMTLSSDRYVLPLKANFKGRMQGIIHDWSQTGETCYFEPMFLVE
INNRLQELKREEREEERKVLLYLRTLLEAELPGAQAALELLAQLDLLQAKRRLAALLDGRCLPLTPVAEGIQLLDARHPL
LLLNRVKSADSSATDSGHTQKSAARAAAAVKPLDIVLRPGERALIITGGNAGGKTVCLKTLGLIAAMTLSGLPVPVGAGS
HLPWFSRMDAFIGDEQSLADNVSTFTAQIEHLAKAWKHLDASGMVLLDEFGAGTDPAQGAALAQAVLDELLDKHTFVLAA
THFPALKSYALTREGARAASMLFDPQSKKPLFKLAYDQVGASQALDVAREHGLPESIVRRAEHYLLQDGQDATALLSRLN
DLAAKREEELVILRQEQDKTRSAARHEREKLEKERLRLHDEVRTKASELMRAWKEGRATHKQALKEMARLRASLVPDDTA
DKSGSVLPIAEHFVVGQQVLHTVFNKRGVVTDVDERRNRVRLEMNGVNLWAEMKALRLPGSQGNPQPVGKPSSILAAAHG
SSSTGGGGARPAGAATGASLRLDMRGLRADVALAELEQFMDKALLAGFREVEVVHGRGTGALRRQVHEFLRTFPAVENFC
LAPEDRGGDGMTIVILR

Sequences:

>Translated_817_residues
MIHARTLQALEYNNVTDYLASLCISGVGRDRALALAPLPQAEDVNLAARVYEEAADWSSRPAAGGSIFILNAFPDVTGFL
HAAQTSRGHAFQPDVDAFWALREVLRLARDAHAAIAVPEAPRQWPHLLALADGTPLPVQLTAALLRCLSDDGLLKDESSP
ELYRLRGELRRLHQGCMRKVKDYALQYNMLAYLQDEFMTLSSDRYVLPLKANFKGRMQGIIHDWSQTGETCYFEPMFLVE
INNRLQELKREEREEERKVLLYLRTLLEAELPGAQAALELLAQLDLLQAKRRLAALLDGRCLPLTPVAEGIQLLDARHPL
LLLNRVKSADSSATDSGHTQKSAARAAAAVKPLDIVLRPGERALIITGGNAGGKTVCLKTLGLIAAMTLSGLPVPVGAGS
HLPWFSRMDAFIGDEQSLADNVSTFTAQIEHLAKAWKHLDASGMVLLDEFGAGTDPAQGAALAQAVLDELLDKHTFVLAA
THFPALKSYALTREGARAASMLFDPQSKKPLFKLAYDQVGASQALDVAREHGLPESIVRRAEHYLLQDGQDATALLSRLN
DLAAKREEELVILRQEQDKTRSAARHEREKLEKERLRLHDEVRTKASELMRAWKEGRATHKQALKEMARLRASLVPDDTA
DKSGSVLPIAEHFVVGQQVLHTVFNKRGVVTDVDERRNRVRLEMNGVNLWAEMKALRLPGSQGNPQPVGKPSSILAAAHG
SSSTGGGGARPAGAATGASLRLDMRGLRADVALAELEQFMDKALLAGFREVEVVHGRGTGALRRQVHEFLRTFPAVENFC
LAPEDRGGDGMTIVILR
>Mature_817_residues
MIHARTLQALEYNNVTDYLASLCISGVGRDRALALAPLPQAEDVNLAARVYEEAADWSSRPAAGGSIFILNAFPDVTGFL
HAAQTSRGHAFQPDVDAFWALREVLRLARDAHAAIAVPEAPRQWPHLLALADGTPLPVQLTAALLRCLSDDGLLKDESSP
ELYRLRGELRRLHQGCMRKVKDYALQYNMLAYLQDEFMTLSSDRYVLPLKANFKGRMQGIIHDWSQTGETCYFEPMFLVE
INNRLQELKREEREEERKVLLYLRTLLEAELPGAQAALELLAQLDLLQAKRRLAALLDGRCLPLTPVAEGIQLLDARHPL
LLLNRVKSADSSATDSGHTQKSAARAAAAVKPLDIVLRPGERALIITGGNAGGKTVCLKTLGLIAAMTLSGLPVPVGAGS
HLPWFSRMDAFIGDEQSLADNVSTFTAQIEHLAKAWKHLDASGMVLLDEFGAGTDPAQGAALAQAVLDELLDKHTFVLAA
THFPALKSYALTREGARAASMLFDPQSKKPLFKLAYDQVGASQALDVAREHGLPESIVRRAEHYLLQDGQDATALLSRLN
DLAAKREEELVILRQEQDKTRSAARHEREKLEKERLRLHDEVRTKASELMRAWKEGRATHKQALKEMARLRASLVPDDTA
DKSGSVLPIAEHFVVGQQVLHTVFNKRGVVTDVDERRNRVRLEMNGVNLWAEMKALRLPGSQGNPQPVGKPSSILAAAHG
SSSTGGGGARPAGAATGASLRLDMRGLRADVALAELEQFMDKALLAGFREVEVVHGRGTGALRRQVHEFLRTFPAVENFC
LAPEDRGGDGMTIVILR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI26638666, Length=347, Percent_Identity=27.6657060518732, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI4505253, Length=347, Percent_Identity=27.6657060518732, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI26638664, Length=348, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI284813531, Length=460, Percent_Identity=23.9130434782609, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI262231786, Length=268, Percent_Identity=30.2238805970149, Blast_Score=75, Evalue=4e-13,
Organism=Homo sapiens, GI4504191, Length=371, Percent_Identity=22.911051212938, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1789089, Length=297, Percent_Identity=29.2929292929293, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539736, Length=369, Percent_Identity=25.4742547425474, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17534743, Length=316, Percent_Identity=24.0506329113924, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17508445, Length=319, Percent_Identity=25.705329153605, Blast_Score=74, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321109, Length=172, Percent_Identity=30.8139534883721, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324482, Length=138, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24664545, Length=205, Percent_Identity=26.3414634146341, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89556; Mature: 89556

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHARTLQALEYNNVTDYLASLCISGVGRDRALALAPLPQAEDVNLAARVYEEAADWSSR
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PAAGGSIFILNAFPDVTGFLHAAQTSRGHAFQPDVDAFWALREVLRLARDAHAAIAVPEA
CCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC
PRQWPHLLALADGTPLPVQLTAALLRCLSDDGLLKDESSPELYRLRGELRRLHQGCMRKV
CCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KDYALQYNMLAYLQDEFMTLSSDRYVLPLKANFKGRMQGIIHDWSQTGETCYFEPMFLVE
HHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCEEEEE
INNRLQELKREEREEERKVLLYLRTLLEAELPGAQAALELLAQLDLLQAKRRLAALLDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
CLPLTPVAEGIQLLDARHPLLLLNRVKSADSSATDSGHTQKSAARAAAAVKPLDIVLRPG
CCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCC
ERALIITGGNAGGKTVCLKTLGLIAAMTLSGLPVPVGAGSHLPWFSRMDAFIGDEQSLAD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
NVSTFTAQIEHLAKAWKHLDASGMVLLDEFGAGTDPAQGAALAQAVLDELLDKHTFVLAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEE
THFPALKSYALTREGARAASMLFDPQSKKPLFKLAYDQVGASQALDVAREHGLPESIVRR
CCCHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCHHHHHH
AEHYLLQDGQDATALLSRLNDLAAKREEELVILRQEQDKTRSAARHEREKLEKERLRLHD
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EVRTKASELMRAWKEGRATHKQALKEMARLRASLVPDDTADKSGSVLPIAEHFVVGQQVL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HTVFNKRGVVTDVDERRNRVRLEMNGVNLWAEMKALRLPGSQGNPQPVGKPSSILAAAHG
HHHHHCCCCEECHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECC
SSSTGGGGARPAGAATGASLRLDMRGLRADVALAELEQFMDKALLAGFREVEVVHGRGTG
CCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCH
ALRRQVHEFLRTFPAVENFCLAPEDRGGDGMTIVILR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MIHARTLQALEYNNVTDYLASLCISGVGRDRALALAPLPQAEDVNLAARVYEEAADWSSR
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCC
PAAGGSIFILNAFPDVTGFLHAAQTSRGHAFQPDVDAFWALREVLRLARDAHAAIAVPEA
CCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEECCCC
PRQWPHLLALADGTPLPVQLTAALLRCLSDDGLLKDESSPELYRLRGELRRLHQGCMRKV
CCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KDYALQYNMLAYLQDEFMTLSSDRYVLPLKANFKGRMQGIIHDWSQTGETCYFEPMFLVE
HHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEECCEEEEE
INNRLQELKREEREEERKVLLYLRTLLEAELPGAQAALELLAQLDLLQAKRRLAALLDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
CLPLTPVAEGIQLLDARHPLLLLNRVKSADSSATDSGHTQKSAARAAAAVKPLDIVLRPG
CCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCC
ERALIITGGNAGGKTVCLKTLGLIAAMTLSGLPVPVGAGSHLPWFSRMDAFIGDEQSLAD
CEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHH
NVSTFTAQIEHLAKAWKHLDASGMVLLDEFGAGTDPAQGAALAQAVLDELLDKHTFVLAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEE
THFPALKSYALTREGARAASMLFDPQSKKPLFKLAYDQVGASQALDVAREHGLPESIVRR
CCCHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHCCCCHHHHHH
AEHYLLQDGQDATALLSRLNDLAAKREEELVILRQEQDKTRSAARHEREKLEKERLRLHD
HHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EVRTKASELMRAWKEGRATHKQALKEMARLRASLVPDDTADKSGSVLPIAEHFVVGQQVL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
HTVFNKRGVVTDVDERRNRVRLEMNGVNLWAEMKALRLPGSQGNPQPVGKPSSILAAAHG
HHHHHCCCCEECHHHCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEECC
SSSTGGGGARPAGAATGASLRLDMRGLRADVALAELEQFMDKALLAGFREVEVVHGRGTG
CCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCH
ALRRQVHEFLRTFPAVENFCLAPEDRGGDGMTIVILR
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA