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The map label for this gene is hisD [H]

Identifier: 220904324

GI number: 220904324

Start: 1230940

End: 1232244

Strand: Reverse

Name: hisD [H]

Synonym: Ddes_1051

Alternate gene names: 220904324

Gene position: 1232244-1230940 (Counterclockwise)

Preceding gene: 220904325

Following gene: 220904323

Centisome position: 42.88

GC content: 60.15

Gene sequence:

>1305_bases
ATGACATGCCGGACTTTGACTCTGCATAATGAGCAGGAGTGGCCCAAGCTTGCCCAATGGCTGCAAGGCCGCAATAACCC
CGGTGACGGGGTGGAAAGCGCTGTGCGCGACATCATCGCTGCTGTGCGCGAAAGGGGCGACGAAGCCCTGGTGGAATATA
CCCGTAATTTTGACTGCCCGGATTTTGCGCCCCCACTGCTCGTCAGCGAGCAGGAAATCGCGCGCGCGGCTGCTTCTGTT
TCCATTGAAAACAGAGAAATCATCAGTCAGGCGGCCACGTACATACGCTCTTTTCATGAAGCGCAGACGGAAAAATCCTG
GTTTACCACACGCCCTGACGGCAGCATTCTCGGCCAGCACGTTTTGCCCGTCGATGCTGCCGGGCTGTACGTGCCCGGCG
GACAAGGCGGCAATACACCGCTTATCTCAAGCCTGCTCATGACAGCCATTCCGGCGCAGGTCGCAGGTGTGCCGCGTCTT
GCCATCTGCACTCCGCCCCGCAAGGACGGCAGCGTCAACCCCCATATTCTTGCTGCGGCCCACCTGCTGGACATTGAAGA
AGTATACCGCGTTGGCGGGGCCTGGTCCGTGGCGGGCATGGCCTATGGCACGCAAAGCATGGCCCCGGTAGACGTCATCG
CCGGACCGGGCAACATCTTTGTCACCACAGCCAAACGCCTGGTGCAAGGCACAGTGGGTATCGACATGATCGCTGGTCCC
AGCGAAGTGCTGATCCTGGCCGACTCTTCCGCCAATGCCGAATGGCTCGCAGCGGACATGCTTTCTCAGGCCGAGCACGA
CACCCTGGCATCGGCAATCTGCGTTACTGACGATCAGCGCCTGGCCGACAATCTCTGGCAGGAGCTCAACAAACAGTGCG
CCGCCCTGCCCAGAGCCACCACCGCAGCCCGCTCGCTTGAAGACTGGGGGGCCATTGTGGTCACGCCCAACCTGAGTGTG
GCCGTAGCCGTGGCCAATATGGTCGCTCCCGAGCACCTGGAAATCTGCACTCGTGACCCTTGGGCCGTTCTGCCCCACAT
CCGCCATGCCGGGGCCATTTTTATGGGCCAGCATAGCCCCGAGGCAGTGGGGGACTATTTCGCCGGTCCGAACCATGTGC
TGCCCACATTGGGTACGGCCCGCTTTTCTTCTGCCCTTTCTGTGCAGACCTTTTGCAAGAGAACCAGCATCGTGGCAACG
TCCCCAACCTTTTTGCAGCAAAATATGCAATCCATTGCCGCCCTTGCACGCATGGAAGGGCTGGAAGCGCACGCGCGCAG
CGTTGAAGCGCGAGCCAAAAAATAA

Upstream 100 bases:

>100_bases
TTAAAAAAGCGCATGCCGGTTGTTCCCCTCAAGCCGCGGCAAGTCTCGACATTCATAGGCGCCTTCTGTATATTCCCTCA
ACCGAGGTGAGGAAAATACT

Downstream 100 bases:

>100_bases
TCGGGCCGACACACCAGGAGCACCCATGAAGGTTGTGGTCAAAACTGACATTACCGCCTACCCGCTGCTTTCACGCGGCA
AGGTGCGCGACATCTACAAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTCRTLTLHNEQEWPKLAQWLQGRNNPGDGVESAVRDIIAAVRERGDEALVEYTRNFDCPDFAPPLLVSEQEIARAAASV
SIENREIISQAATYIRSFHEAQTEKSWFTTRPDGSILGQHVLPVDAAGLYVPGGQGGNTPLISSLLMTAIPAQVAGVPRL
AICTPPRKDGSVNPHILAAAHLLDIEEVYRVGGAWSVAGMAYGTQSMAPVDVIAGPGNIFVTTAKRLVQGTVGIDMIAGP
SEVLILADSSANAEWLAADMLSQAEHDTLASAICVTDDQRLADNLWQELNKQCAALPRATTAARSLEDWGAIVVTPNLSV
AVAVANMVAPEHLEICTRDPWAVLPHIRHAGAIFMGQHSPEAVGDYFAGPNHVLPTLGTARFSSALSVQTFCKRTSIVAT
SPTFLQQNMQSIAALARMEGLEAHARSVEARAKK

Sequences:

>Translated_434_residues
MTCRTLTLHNEQEWPKLAQWLQGRNNPGDGVESAVRDIIAAVRERGDEALVEYTRNFDCPDFAPPLLVSEQEIARAAASV
SIENREIISQAATYIRSFHEAQTEKSWFTTRPDGSILGQHVLPVDAAGLYVPGGQGGNTPLISSLLMTAIPAQVAGVPRL
AICTPPRKDGSVNPHILAAAHLLDIEEVYRVGGAWSVAGMAYGTQSMAPVDVIAGPGNIFVTTAKRLVQGTVGIDMIAGP
SEVLILADSSANAEWLAADMLSQAEHDTLASAICVTDDQRLADNLWQELNKQCAALPRATTAARSLEDWGAIVVTPNLSV
AVAVANMVAPEHLEICTRDPWAVLPHIRHAGAIFMGQHSPEAVGDYFAGPNHVLPTLGTARFSSALSVQTFCKRTSIVAT
SPTFLQQNMQSIAALARMEGLEAHARSVEARAKK
>Mature_433_residues
TCRTLTLHNEQEWPKLAQWLQGRNNPGDGVESAVRDIIAAVRERGDEALVEYTRNFDCPDFAPPLLVSEQEIARAAASVS
IENREIISQAATYIRSFHEAQTEKSWFTTRPDGSILGQHVLPVDAAGLYVPGGQGGNTPLISSLLMTAIPAQVAGVPRLA
ICTPPRKDGSVNPHILAAAHLLDIEEVYRVGGAWSVAGMAYGTQSMAPVDVIAGPGNIFVTTAKRLVQGTVGIDMIAGPS
EVLILADSSANAEWLAADMLSQAEHDTLASAICVTDDQRLADNLWQELNKQCAALPRATTAARSLEDWGAIVVTPNLSVA
VAVANMVAPEHLEICTRDPWAVLPHIRHAGAIFMGQHSPEAVGDYFAGPNHVLPTLGTARFSSALSVQTFCKRTSIVATS
PTFLQQNMQSIAALARMEGLEAHARSVEARAKK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=406, Percent_Identity=39.6551724137931, Blast_Score=265, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6319819, Length=418, Percent_Identity=35.6459330143541, Blast_Score=234, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46428; Mature: 46297

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCRTLTLHNEQEWPKLAQWLQGRNNPGDGVESAVRDIIAAVRERGDEALVEYTRNFDCP
CCCEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DFAPPLLVSEQEIARAAASVSIENREIISQAATYIRSFHEAQTEKSWFTTRPDGSILGQH
CCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
VLPVDAAGLYVPGGQGGNTPLISSLLMTAIPAQVAGVPRLAICTPPRKDGSVNPHILAAA
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHH
HLLDIEEVYRVGGAWSVAGMAYGTQSMAPVDVIAGPGNIFVTTAKRLVQGTVGIDMIAGP
HHHHHHHHHHCCCCEEEHHHHCCCCCCCCEEEEECCCCEEEEEHHHHHHHCCCEEEECCC
SEVLILADSSANAEWLAADMLSQAEHDTLASAICVTDDQRLADNLWQELNKQCAALPRAT
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHH
TAARSLEDWGAIVVTPNLSVAVAVANMVAPEHLEICTRDPWAVLPHIRHAGAIFMGQHSP
HHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCEEEECCCCC
EAVGDYFAGPNHVLPTLGTARFSSALSVQTFCKRTSIVATSPTFLQQNMQSIAALARMEG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHH
LEAHARSVEARAKK
HHHHHHHHHHHCCC
>Mature Secondary Structure 
TCRTLTLHNEQEWPKLAQWLQGRNNPGDGVESAVRDIIAAVRERGDEALVEYTRNFDCP
CCEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCC
DFAPPLLVSEQEIARAAASVSIENREIISQAATYIRSFHEAQTEKSWFTTRPDGSILGQH
CCCCCCEECHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCC
VLPVDAAGLYVPGGQGGNTPLISSLLMTAIPAQVAGVPRLAICTPPRKDGSVNPHILAAA
CCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHH
HLLDIEEVYRVGGAWSVAGMAYGTQSMAPVDVIAGPGNIFVTTAKRLVQGTVGIDMIAGP
HHHHHHHHHHCCCCEEEHHHHCCCCCCCCEEEEECCCCEEEEEHHHHHHHCCCEEEECCC
SEVLILADSSANAEWLAADMLSQAEHDTLASAICVTDDQRLADNLWQELNKQCAALPRAT
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHCCCHH
TAARSLEDWGAIVVTPNLSVAVAVANMVAPEHLEICTRDPWAVLPHIRHAGAIFMGQHSP
HHHHHHHHCCEEEECCCCHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHCCEEEECCCCC
EAVGDYFAGPNHVLPTLGTARFSSALSVQTFCKRTSIVATSPTFLQQNMQSIAALARMEG
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHH
LEAHARSVEARAKK
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA