Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 220904323

GI number: 220904323

Start: 1230033

End: 1230914

Strand: Reverse

Name: purC [H]

Synonym: Ddes_1050

Alternate gene names: 220904323

Gene position: 1230914-1230033 (Counterclockwise)

Preceding gene: 220904324

Following gene: 220904321

Centisome position: 42.84

GC content: 54.88

Gene sequence:

>882_bases
ATGAAGGTTGTGGTCAAAACTGACATTACCGCCTACCCGCTGCTTTCACGCGGCAAGGTGCGCGACATCTACAACGTGGA
CGAAAAAACACTGCTCATCGTTACCACAGACAGAATGTCGGCCTTTGACGTGATCATGAACGAGCCTATCCCCTACAAGG
GGGTAATTCTGAACCAGATCACCCTGTTCTGGATGGAAAAGTTCAAGAGCATTATCCCCAACCATCTGCTGGAAAGCGAT
GTGAACCGCTTTCCAGACAGACTGGCCCCCTGGAAAGACGAGCTTGAAGGACGCGCAGTGCTTGTACGCAAGGCGGCCCC
CCTGCCTGTGGAATGCATCGTGCGCGGCTATATCACGGGGTCCGGCTGGAGCGACTATCAGACCACCGGCACCCTTTGCG
GCTATACGCTGCCCCCCGGTCTGCAGGAGTCCGACAAACTTGAGCCTGCCATCTTTACCCCCTCTACCAAGGCAGAACTG
GGCAAGCATGACGAAAACCTGAGCGTGGCCGAAGCTGCCCGCCTGCTGGGTGAAGACATGGCCCGTCAGGTTGAGCAGAC
CTCTCTGGCCATCTACGAAGCCGGACGAGCCTATGCTGCAAGCCGCGGCATTATCGTGGCAGACACCAAATTTGAATTTG
GTTTTATCGACGGCAGGTTGCACCTCATTGATGAAGTTCTCACTCCCGATTCCTCGCGCTTCTGGCCTGCGGATCAGTAC
AAGGCCGGGCAGGGGCAGCCCAGTTTTGACAAACAGTACCTGCGCGACTGGCTGAAAGCACAACCCTGGGATATGCAGCC
TCCACCGCCGCCCCTGCCTGAGGACATTATAAAAATCACTGCGGATAAATACAAAGAAGCCTACGAAATTATTACAAAAT
AA

Upstream 100 bases:

>100_bases
TCCATTGCCGCCCTTGCACGCATGGAAGGGCTGGAAGCGCACGCGCGCAGCGTTGAAGCGCGAGCCAAAAAATAATCGGG
CCGACACACCAGGAGCACCC

Downstream 100 bases:

>100_bases
ACAGTAGATATGCCCGTGCCGTCAACGGTGTGGGCTTGCGGCTTTGCATCTGCCGTGCGAAGGATCATCGCCGTATGTCA
CGCATGCCTGACATCAGCGC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MKVVVKTDITAYPLLSRGKVRDIYNVDEKTLLIVTTDRMSAFDVIMNEPIPYKGVILNQITLFWMEKFKSIIPNHLLESD
VNRFPDRLAPWKDELEGRAVLVRKAAPLPVECIVRGYITGSGWSDYQTTGTLCGYTLPPGLQESDKLEPAIFTPSTKAEL
GKHDENLSVAEAARLLGEDMARQVEQTSLAIYEAGRAYAASRGIIVADTKFEFGFIDGRLHLIDEVLTPDSSRFWPADQY
KAGQGQPSFDKQYLRDWLKAQPWDMQPPPPPLPEDIIKITADKYKEAYEIITK

Sequences:

>Translated_293_residues
MKVVVKTDITAYPLLSRGKVRDIYNVDEKTLLIVTTDRMSAFDVIMNEPIPYKGVILNQITLFWMEKFKSIIPNHLLESD
VNRFPDRLAPWKDELEGRAVLVRKAAPLPVECIVRGYITGSGWSDYQTTGTLCGYTLPPGLQESDKLEPAIFTPSTKAEL
GKHDENLSVAEAARLLGEDMARQVEQTSLAIYEAGRAYAASRGIIVADTKFEFGFIDGRLHLIDEVLTPDSSRFWPADQY
KAGQGQPSFDKQYLRDWLKAQPWDMQPPPPPLPEDIIKITADKYKEAYEIITK
>Mature_293_residues
MKVVVKTDITAYPLLSRGKVRDIYNVDEKTLLIVTTDRMSAFDVIMNEPIPYKGVILNQITLFWMEKFKSIIPNHLLESD
VNRFPDRLAPWKDELEGRAVLVRKAAPLPVECIVRGYITGSGWSDYQTTGTLCGYTLPPGLQESDKLEPAIFTPSTKAEL
GKHDENLSVAEAARLLGEDMARQVEQTSLAIYEAGRAYAASRGIIVADTKFEFGFIDGRLHLIDEVLTPDSSRFWPADQY
KAGQGQPSFDKQYLRDWLKAQPWDMQPPPPPLPEDIIKITADKYKEAYEIITK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=300, Percent_Identity=48.6666666666667, Blast_Score=277, Evalue=2e-75,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33095; Mature: 33095

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVVKTDITAYPLLSRGKVRDIYNVDEKTLLIVTTDRMSAFDVIMNEPIPYKGVILNQI
CEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCHHHHHH
TLFWMEKFKSIIPNHLLESDVNRFPDRLAPWKDELEGRAVLVRKAAPLPVECIVRGYITG
HHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHCCCCEEEEECCCCCCHHHHEEEEEEC
SGWSDYQTTGTLCGYTLPPGLQESDKLEPAIFTPSTKAELGKHDENLSVAEAARLLGEDM
CCCCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCHHHHHHHHHHHH
ARQVEQTSLAIYEAGRAYAASRGIIVADTKFEFGFIDGRLHLIDEVLTPDSSRFWPADQY
HHHHHHHHHHHHHCCCHHHHCCCEEEEECCEEEEEECCHHHHHHHHHCCCCCCCCCCCCC
KAGQGQPSFDKQYLRDWLKAQPWDMQPPPPPLPEDIIKITADKYKEAYEIITK
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVVVKTDITAYPLLSRGKVRDIYNVDEKTLLIVTTDRMSAFDVIMNEPIPYKGVILNQI
CEEEEECCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCHHHHHH
TLFWMEKFKSIIPNHLLESDVNRFPDRLAPWKDELEGRAVLVRKAAPLPVECIVRGYITG
HHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHCCCCEEEEECCCCCCHHHHEEEEEEC
SGWSDYQTTGTLCGYTLPPGLQESDKLEPAIFTPSTKAELGKHDENLSVAEAARLLGEDM
CCCCCCCCCCCEECCCCCCCCCCCCCCCCEEECCCCHHHHCCCCCCCCHHHHHHHHHHHH
ARQVEQTSLAIYEAGRAYAASRGIIVADTKFEFGFIDGRLHLIDEVLTPDSSRFWPADQY
HHHHHHHHHHHHHCCCHHHHCCCEEEEECCEEEEEECCHHHHHHHHHCCCCCCCCCCCCC
KAGQGQPSFDKQYLRDWLKAQPWDMQPPPPPLPEDIIKITADKYKEAYEIITK
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA