Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 21910377

GI number: 21910377

Start: 894904

End: 896466

Strand: Reverse

Name: ffh [H]

Synonym: SpyM3_0841

Alternate gene names: 21910377

Gene position: 896466-894904 (Counterclockwise)

Preceding gene: 21910378

Following gene: 21910375

Centisome position: 47.17

GC content: 40.5

Gene sequence:

>1563_bases
ATGGCTTTTGAAAGCTTAACCCAACGTTTGCAAGATGTGTTTAAACACATTCGCGGTAAAAAGAAATTATCAGAATCAGA
TGTTCAAGAAGTGACAAAAGAGATTCGTCTAGCTCTTTTAGAAGCCGATGTCGCTTTACCAGTTGTTAAAACCTTTATTA
AGCGCGTACGTGAGCGCGCTATTGGCCATGAGATTATTGATACTCTTGATCCAACACAACAAATTCTTAAGATTGTTAAT
GAAGAATTAACGAGTATTTTAGGCTCAGAAACCGCGGAGATTGATAAATCTCCAAAAATTCCAACTATTATCATGATGGT
CGGTTTGCAAGGGACTGGTAAAACCACTTTTGCAGGAAAACTCGCTAATAAATTAATTAAAGAAGAAAACGCGCGACCAC
TGATGATTGCTGCCGATATTTACCGTCCAGCGGCCATTGATCAGTTAAAAACACTGGGGCAACAAATCAATGTACCTGTT
TTTGATATGGGGACAGACCACTCAGCAGTCGATATTGTCAGAAAAGGTTTGGAACAAGCTCGTGAAAACCGCAATGACTA
TGTCTTGATTGATACTGCGGGTCGCTTGCAAATTGATGAAAAACTGATGGAAGAGCTGCGCGATGTCAAGGCTTTAGCAC
AACCAAATGAAATTCTTTTGGTTGTAGATAGCATGATTGGTCAAGAAGCTGCCAATGTAGCCTACGAGTTTAATCATCAG
TTGAGCATCACAGGGGTTGTGTTAACAAAGATTGATGGTGATACCCGTGGAGGTGCAGCACTATCTGTCCGTGAAATCAC
TGGAAAACCAATTAAATTTACAGGTATTGGTGAAAAAATCACAGATATTGAAACATTTCACCCAGACCGCATGTCCAGTC
GGATTTTGGGAATGGGTGACTTACTCACTCTTATTGAAAAAGCTAGCCAGGAATATGATGAGAAAAAATCCTTAGAGTTA
GCTGAAAAAATGCGTGAGAACACCTTTGATTTCAATGATTTCATTGAACAGTTAGATCAAGTGCAAAATATGGGGCCTAT
GGAAGACCTCTTGAAAATGATTCCAGGAATGGCTGGTAACCCAGCTTTGGCCAATATCAAAGTTGACGAAAACCAAATTG
CTCGCAAACGTGCTATTGTCTCTTCGATGACCCCCGCTGAACGTGAAAACCCTGACTTACTAAACCCGAGTCGTCGCCGT
CGTATTGCAGCTGGTTCCGGGAACAGCTTTGTGGAAGTTAATAAATTTATCAAAGACTTTAACCAAGCCAAAAGCATGAT
GCAAGGGGTTATGTCGGGCGATATGTCTAAGATGATGAAAGATATGGGCATTAATCCCAATAATCTTCCTAAAAACATGC
CTGCTGGTATGCCAGATATGTCTTCCTTAGAAGGGATGATGGGACAAGGTGGTATGCCTGATTTATCTGGCCTTGGTGGT
GATATGGATATGAGTCAACTATTTGGTAAAGGGTTCAAGGGGAAAATTGGACAATTTGCCATGAAACAGGCCATGAAACG
TCAAGCTAACAAACTAAAAAAAGCAAAGAAAAAACGAAAATAA

Upstream 100 bases:

>100_bases
TTGACGACATGATTGCTCACTACCCTCATGATGAGTATTTGCAAGAAAAAATTTCCATTCTAACCAGTATTGACAATAGA
GAGTAAGAGGAGTTTTGACT

Downstream 100 bases:

>100_bases
AAGAGACGGAAATTTTCGTCTCTTTTTGATGTGAAATTCATTTATCTTGTATACAAGATTATTAAAATTATGGAAGACCG
CGTTACATGCATGATGAGTT

Product: putative signal recognition particle -inhibited division protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGTGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Sequences:

>Translated_520_residues
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVN
EELTSILGSETAEIDKSPKIPTIIMMVGLQGTGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPV
FDMGTDHSAVDIVRKGLEQARENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLEL
AEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRR
RIAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
>Mature_519_residues
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERAIGHEIIDTLDPTQQILKIVNE
ELTSILGSETAEIDKSPKIPTIIMMVGLQGTGKTTFAGKLANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVF
DMGTDHSAVDIVRKGLEQARENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQL
SITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGDLLTLIEKASQEYDEKKSLELA
EKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGNPALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRR
IAAGSGNSFVEVNKFIKDFNQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGGD
MDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=452, Percent_Identity=30.7522123893805, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI226371618, Length=389, Percent_Identity=31.8766066838046, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI295424842, Length=308, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI23308697, Length=308, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI89061728, Length=146, Percent_Identity=36.3013698630137, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=420, Percent_Identity=48.0952380952381, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1789874, Length=269, Percent_Identity=33.457249070632, Blast_Score=148, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=494, Percent_Identity=27.3279352226721, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.4314381270903, Blast_Score=113, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=467, Percent_Identity=30.406852248394, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=26.031746031746, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17647949, Length=497, Percent_Identity=30.1810865191147, Blast_Score=196, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24641198, Length=311, Percent_Identity=30.5466237942122, Blast_Score=122, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57651; Mature: 57520

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CCHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGTGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFESLTQRLQDVFKHIRGKKKLSESDVQEVTKEIRLALLEADVALPVVKTFIKRVRERA
CHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGHEIIDTLDPTQQILKIVNEELTSILGSETAEIDKSPKIPTIIMMVGLQGTGKTTFAGK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCEEEEEEECCCCCCCHHHHH
LANKLIKEENARPLMIAADIYRPAAIDQLKTLGQQINVPVFDMGTDHSAVDIVRKGLEQA
HHHHHHHHCCCCCEEEEHHHHCCHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
RENRNDYVLIDTAGRLQIDEKLMEELRDVKALAQPNEILLVVDSMIGQEAANVAYEFNHQ
HHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHEECCE
LSITGVVLTKIDGDTRGGAALSVREITGKPIKFTGIGEKITDIETFHPDRMSSRILGMGD
EEEEEEEEEEECCCCCCCCEEEEHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHCCHHH
LLTLIEKASQEYDEKKSLELAEKMRENTFDFNDFIEQLDQVQNMGPMEDLLKMIPGMAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
PALANIKVDENQIARKRAIVSSMTPAERENPDLLNPSRRRRIAAGSGNSFVEVNKFIKDF
CCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCEEECCCCCCHHHHHHHHHHH
NQAKSMMQGVMSGDMSKMMKDMGINPNNLPKNMPAGMPDMSSLEGMMGQGGMPDLSGLGG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCC
DMDMSQLFGKGFKGKIGQFAMKQAMKRQANKLKKAKKKRK
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]