Definition Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession NC_004070
Length 1,900,521

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The map label for this gene is prfA [H]

Identifier: 21910335

GI number: 21910335

Start: 850585

End: 851664

Strand: Direct

Name: prfA [H]

Synonym: SpyM3_0799

Alternate gene names: 21910335

Gene position: 850585-851664 (Clockwise)

Preceding gene: 21910334

Following gene: 21910336

Centisome position: 44.76

GC content: 36.94

Gene sequence:

>1080_bases
ATGAATATTTATGATCAATTGCAGGCAGTTGAAGATCGTTATGAAGAGTTAGGTGAGTTACTTAGTGATCCAGATGTTGT
TTCAGATACAAAGCGATTTATGGAATTATCACGTGAAGAAGCTAATACTCGAGAAACTGTCACAGCTTATAGAGAATATA
AGCAAGTCATTCAAACCATTTCAGATGCTGAAGAAATGATCAAAGATGCCAGTGGTGATCCTGAATTAGAAGAAATGGCT
AAAGAAGAACTTAAAGAATCAAAAGCAGCTAAAGAAGAGTATGAAGAAAAATTAAAAATTCTTCTATTACCTAAAGATCC
TAACGATGATAAAAATATTATTTTAGAAATTCGTGGTGCTGCTGGTGGCGATGAGGCAGCGCTTTTTGCTGGTGATCTTT
TAACAATGTATCAAAAATATGCTGAAACTCAAGGATGGCGTTTTGAAGTTATGGAATCATCCGTTAATGGTGTTGGTGGT
ATTAAAGAAGTGGTTGCCATGGTTTCTGGTCAGTCAGTTTATTCTAAGCTTAAATATGAATCAGGAGCTCATCGTGTTCA
ACGTGTCCCAGTGACAGAGAGTCAGGGTCGTGTTCATACTTCAACTGCAACTGTTTTGGTAATGCCAGAAGTTGAAGAAG
TAGAATACGACATTGATCCTAAAGACTTACGTATTGATATTTACCACGCGTCTGGTGCTGGTGGTCAGAACGTCAATAAA
GTTGCTACTGCAGTTCGTATGGTACACATTCCTACAGGAATCAAAGTTGAAATGCAAGAAGAGCGTACTCAGCAAAAAAA
CCGTGATAAAGCGATGAAAATCATTCGTGCTCGTGTTGCTGACCATTTTGCGCAAATTGCTCAAGATGAGCAAGATGCTG
AACGTAAATCAACAGTTGGTACTGGTGATCGTTCAGAACGTATTCGTACTTATAATTTCCCACAAAATCGTGTAACAGAT
CATCGTATTGGTTTGACACTTCAAAAATTAGATACTATTTTATCTGGAAAAATGGATGAAGTTATTGATGCACTCGTTAT
GTATGATCAGACAAAGAAATTAGAATCTCTCAATAACTAA

Upstream 100 bases:

>100_bases
CAAATTGGTGGTAATGAAACCTATATCCCAGTTTGTCGAAAACATTATTTTAATCCAGAGATTTAAAAGGTAATCAGTTT
TAAAGGAGATACAAAGAAAA

Downstream 100 bases:

>100_bases
TGAACTATGCTACATTAATCAGAACTTATGAAGATAAACTAGAACAAATAGATGAGGATCGCGAAAATCTCGCCTATGTT
TTTAGAGAAATCAAAGAATG

Product: peptide chain release factor 1

Products: NA

Alternate protein names: RF-1 [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMA
KEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGG
IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNK
VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTD
HRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN

Sequences:

>Translated_359_residues
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMA
KEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGG
IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNK
VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTD
HRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
>Mature_359_residues
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTISDAEEMIKDASGDPELEEMA
KEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGG
IKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNK
VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVGTGDRSERIRTYNFPQNRVTD
HRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN

Specific function: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA [H]

COG id: COG0216

COG function: function code J; Protein chain release factor A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic/mitochondrial release factor family [H]

Homologues:

Organism=Homo sapiens, GI166795303, Length=292, Percent_Identity=43.4931506849315, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI34577120, Length=349, Percent_Identity=37.8223495702006, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI166795305, Length=196, Percent_Identity=41.8367346938776, Blast_Score=174, Evalue=1e-43,
Organism=Escherichia coli, GI1787462, Length=360, Percent_Identity=49.4444444444444, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI2367172, Length=349, Percent_Identity=35.8166189111748, Blast_Score=195, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17542784, Length=288, Percent_Identity=39.2361111111111, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321295, Length=318, Percent_Identity=41.8238993710692, Blast_Score=247, Evalue=2e-66,
Organism=Drosophila melanogaster, GI19921226, Length=344, Percent_Identity=37.5, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005139
- InterPro:   IPR000352
- InterPro:   IPR004373 [H]

Pfam domain/function: PF03462 PCRF; PF00472 RF-1 [H]

EC number: NA

Molecular weight: Translated: 40583; Mature: 40583

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00745 RF_PROK_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTI
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECC
AGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYE
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHC
SGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNK
CCCHHHEECCCCCCCCEEEECCEEEEEECCHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVG
HHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
TGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIYDQLQAVEDRYEELGELLSDPDVVSDTKRFMELSREEANTRETVTAYREYKQVIQTI
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
SDAEEMIKDASGDPELEEMAKEELKESKAAKEEYEEKLKILLLPKDPNDDKNIILEIRGA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEEEEECC
AGGDEAALFAGDLLTMYQKYAETQGWRFEVMESSVNGVGGIKEVVAMVSGQSVYSKLKYE
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHCCHHHHHHHHHC
SGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRIDIYHASGAGGQNVNK
CCCHHHEECCCCCCCCEEEECCEEEEEECCHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
VATAVRMVHIPTGIKVEMQEERTQQKNRDKAMKIIRARVADHFAQIAQDEQDAERKSTVG
HHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
TGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKMDEVIDALVMYDQTKKLESLNN
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA