Definition Streptococcus pyogenes MGAS315 chromosome, complete genome.
Accession NC_004070
Length 1,900,521

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The map label for this gene is folE [H]

Identifier: 21910295

GI number: 21910295

Start: 813821

End: 814423

Strand: Direct

Name: folE [H]

Synonym: SpyM3_0759

Alternate gene names: 21910295

Gene position: 813821-814423 (Clockwise)

Preceding gene: 21910294

Following gene: 21910296

Centisome position: 42.82

GC content: 40.46

Gene sequence:

>603_bases
ATGAAAAGGAAAAAACTAATGAAAAGGGAAAGACTAATGTCTATTAATAAGGAAAAAGCAGAAGCAGCCATTTATCAGTT
TTTAGAGGCTATTGGTGAAAATCCAAATCGGGAAGGTCTTCTTGACACGCCTAAACGGGTTGCTAAAATGTATGCGGAGA
TGTTTTTGGGACTGGGAAAAGATCCTAAAGAGGAATTTACGGCTGTCTTTAAAGAACACCATGAGGATGTGGTGATTGTC
AAAGACATTAGTTTTTATTCTGTATGTGAGCACCACTTAGTTCCTTTTTATGGCAAGGCTCATATCGCTTACTTACCAAG
TGATGGTCGAGTAACAGGTTTGAGTAAATTAGCGCGAGCAGTTGAAGTAGCTAGTAAACGACCTCAACTCCAAGAGCGTT
TGACCTCTCAAATAGCGGATGCTTTAGTTGAAGCCCTCAATCCTAAAGGGACTTTAGTTATGGTAGAAGCAGAGCACATG
TGCATGACCATGCGAGGCATCAAAAAGCCAGGTAGTAAAACCATTACCACCACTGCCAGAGGCTTATATAAGGAAAGTCG
TGCTGAGAGGCAAGAAGTTATTTCTCTAATGACAAAAGATTAG

Upstream 100 bases:

>100_bases
ATTACAGGGTCACTATATTTTATTTCAGAAATTAGACGGTATTGGAAAAAACATATTGAAAAAAGCGTTCTTTTAACCCA
TTAAAAAAGAGAAAATGAAA

Downstream 100 bases:

>100_bases
GAGAACTTATGAAAATTGGAAAGTTTGTGATTGAGGGCAATGCGGCTATCATGGGGATTTTAAATGTGACTCCAGATTCT
TTTTCAGATGGGGGGTCTTA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 200; Mature: 200

Protein sequence:

>200_residues
MKRKKLMKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLGLGKDPKEEFTAVFKEHHEDVVIV
KDISFYSVCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHM
CMTMRGIKKPGSKTITTTARGLYKESRAERQEVISLMTKD

Sequences:

>Translated_200_residues
MKRKKLMKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLGLGKDPKEEFTAVFKEHHEDVVIV
KDISFYSVCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHM
CMTMRGIKKPGSKTITTTARGLYKESRAERQEVISLMTKD
>Mature_200_residues
MKRKKLMKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLGLGKDPKEEFTAVFKEHHEDVVIV
KDISFYSVCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHM
CMTMRGIKKPGSKTITTTARGLYKESRAERQEVISLMTKD

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=190, Percent_Identity=50, Blast_Score=180, Evalue=6e-46,
Organism=Homo sapiens, GI4503949, Length=190, Percent_Identity=50, Blast_Score=180, Evalue=6e-46,
Organism=Homo sapiens, GI66932970, Length=150, Percent_Identity=51.3333333333333, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI66932972, Length=150, Percent_Identity=51.3333333333333, Blast_Score=138, Evalue=3e-33,
Organism=Escherichia coli, GI1788476, Length=159, Percent_Identity=42.7672955974843, Blast_Score=113, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17560486, Length=183, Percent_Identity=47.5409836065574, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321706, Length=184, Percent_Identity=47.2826086956522, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24656782, Length=175, Percent_Identity=49.7142857142857, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656796, Length=175, Percent_Identity=49.7142857142857, Blast_Score=166, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24656791, Length=175, Percent_Identity=49.7142857142857, Blast_Score=166, Evalue=9e-42,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22652; Mature: 22652

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKKLMKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLGLGK
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPKEEFTAVFKEHHEDVVIVKDISFYSVCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARA
CCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
VEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTITTTAR
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHH
GLYKESRAERQEVISLMTKD
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRKKLMKRERLMSINKEKAEAAIYQFLEAIGENPNREGLLDTPKRVAKMYAEMFLGLGK
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
DPKEEFTAVFKEHHEDVVIVKDISFYSVCEHHLVPFYGKAHIAYLPSDGRVTGLSKLARA
CCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHH
VEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTITTTAR
HHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHH
GLYKESRAERQEVISLMTKD
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]