Definition | Streptococcus pyogenes MGAS315 chromosome, complete genome. |
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Accession | NC_004070 |
Length | 1,900,521 |
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The map label for this gene is folC.1 [H]
Identifier: 21910294
GI number: 21910294
Start: 812527
End: 813804
Strand: Direct
Name: folC.1 [H]
Synonym: SpyM3_0758
Alternate gene names: 21910294
Gene position: 812527-813804 (Clockwise)
Preceding gene: 21910293
Following gene: 21910295
Centisome position: 42.75
GC content: 40.22
Gene sequence:
>1278_bases ATGACTTATGAAGAGACTCTAGAATGGATTCATGATCACTTAGTTTTCGGCATCAAGCCAGGCTTAAAACGTATGCTTTG GGTTCTTGGACAGTTAGGAAATCCCCAAAAAAATGTCAAGGGAGTGCATATCGTTGGAACTAACGGAAAAGGTTCCACGG TCAATCATTTACAACACATTTTTACGACAGCTGGTTATGAAGTGGGGACCTTTACCTCTCCTTATATTATGGATTTCAAA GAACGTATTAGCATAAATGGTCGAATGATTTCAGAAAAAGATTTGGTTATTGCTGCTAATCGTATTCGTCCTTTGACAGA GCGTCTAGTTCAAGAGACTGATTTTGGAGAGGTAACTGAATTTGAAGTGATTACTTTGATCATGTTCCTCTATTTTGGAG ACATGCATCCTGTAGATATTGCTATTATTGAAGCAGGCCTTGGCGGTCTTTATGATTCGACCAATGTTTTTCAAGCAATG GTTGTGGTCTGTCCCTCAATTGGTTTAGATCACCAAGCTATTTTGGGCGAGACTTACGCTGATATTGCCGCCCAAAAAGC TGGTGTTTTAGAAGGGGGCGAGACCCTTGTTTTTGCCGTTGAAAACCCGTCAGCTCGAGAGGTTTTTTTAACAAAAGCTG AGCAGGTTGGTGCTTCAATCTGGGAATGGCAAGAGCAGTTTCAAATGGCTGAGAACGCATCTGGCTATCGTTTTACTAGT CCTTTAGGAGTTATTTCAGATATTCACATCGCTATGCCAGGACACCACCAAGTGTCTAATGCAGCTTTAGCTATTATGAC TTGCTTAACCTTGAAAGACCGCTATCCTAGGCTAACTTCAGATCATATAAGGGAAGGTCTAGCAAATAGTTTGTGGCTAG GCCGTACCGAATTATTAGCACCAAATCTAATGATTGATGGGGCTCATAACAATGAAAGCGTTGCTGCTTTGGTAGCCGTC TTAAAAAATAACTACAATGATAAAAAGCTTCATATTTTGTTTGGTGCGATCGACACCAAGCCTATTGCAGATATGTTGGT TGCTCTTGAGCAAATAGGTGACTTGCAGGTTACTAGCTTTCATTACCCTAACGCCTATCCATTGGAAAAATACCCAGAAC GTTTTGGTAGGGTTGCTGATTTCAAAGATTTCTTGGCCCTGCGTAAGCATGCTAAAGCAGATGACTTTTTCGTGATTACA GGGTCACTATATTTTATTTCAGAAATTAGACGGTATTGGAAAAAACATATTGAAAAAAGCGTTCTTTTAACCCATTAA
Upstream 100 bases:
>100_bases GTGTTTGGTGAGGATAATAAAAAAAAGGGTACTACTCTAGGTTATCTGCTGTCACTTTTTTTTTATATATGGTATACTAA AGATAGATGTGAGGTGTGAA
Downstream 100 bases:
>100_bases AAAAGAGAAAATGAAAATGAAAAGGAAAAAACTAATGAAAAGGGAAAGACTAATGTCTATTAATAAGGAAAAAGCAGAAG CAGCCATTTATCAGTTTTTA
Product: dihydrofolate synthase
Products: NA
Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase [H]
Number of amino acids: Translated: 425; Mature: 424
Protein sequence:
>425_residues MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFK ERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAM VVVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAV LKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVIT GSLYFISEIRRYWKKHIEKSVLLTH
Sequences:
>Translated_425_residues MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFK ERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAM VVVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAV LKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVIT GSLYFISEIRRYWKKHIEKSVLLTH >Mature_424_residues TYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKE RISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMV VVCPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTSP LGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVL KNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVITG SLYFISEIRRYWKKHIEKSVLLTH
Specific function: Conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10- formyltetrahydrofolate as folate substrate [H]
COG id: COG0285
COG function: function code H; Folylpolyglutamate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the folylpolyglutamate synthase family [H]
Homologues:
Organism=Homo sapiens, GI66932984, Length=318, Percent_Identity=29.559748427673, Blast_Score=124, Evalue=1e-28, Organism=Homo sapiens, GI66932990, Length=318, Percent_Identity=29.559748427673, Blast_Score=124, Evalue=1e-28, Organism=Escherichia coli, GI1788654, Length=399, Percent_Identity=25.31328320802, Blast_Score=120, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17553150, Length=344, Percent_Identity=25.5813953488372, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71984923, Length=344, Percent_Identity=25.5813953488372, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17553148, Length=344, Percent_Identity=25.5813953488372, Blast_Score=100, Evalue=1e-21, Organism=Saccharomyces cerevisiae, GI6323760, Length=447, Percent_Identity=26.8456375838926, Blast_Score=136, Evalue=6e-33, Organism=Saccharomyces cerevisiae, GI6324815, Length=302, Percent_Identity=28.476821192053, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI24641571, Length=335, Percent_Identity=26.5671641791045, Blast_Score=104, Evalue=1e-22, Organism=Drosophila melanogaster, GI24581568, Length=208, Percent_Identity=25.4807692307692, Blast_Score=72, Evalue=7e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR018109 - InterPro: IPR001645 - InterPro: IPR004101 - InterPro: IPR013221 [H]
Pfam domain/function: PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.17 [H]
Molecular weight: Translated: 47604; Mature: 47473
Theoretical pI: Translated: 6.16; Mature: 6.16
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.6 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHI CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHH FTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTE HHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEEHHCCHHHHHHHHCCCCCCCHH FEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVVCPSIGLDHQAILGETYA HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH DIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS HHHHHHCCCCCCCCEEEEEECCCCCCHHHEECHHHHCCHHHHHHHHHHHHHCCCCCEEEC PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLA CCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCC PNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSF CCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEE HYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVITGSLYFISEIRRYWKKHIEKS ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH VLLTH HCCCC >Mature Secondary Structure TYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIVGTNGKGSTVNHLQHI CHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHH FTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRPLTERLVQETDFGEVTE HHHCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCEEEEEHHCCHHHHHHHHCCCCCCCHH FEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVVCPSIGLDHQAILGETYA HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHH DIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWEWQEQFQMAENASGYRFTS HHHHHHCCCCCCCCEEEEEECCCCCCHHHEECHHHHCCHHHHHHHHHHHHHCCCCCEEEC PLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTSDHIREGLANSLWLGRTELLA CCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCC PNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTKPIADMLVALEQIGDLQVTSF CCEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCEEEEEE HYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVITGSLYFISEIRRYWKKHIEKS ECCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHH VLLTH HCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8419299; 9384377; 2553669 [H]