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The map label for this gene is folP [H]

Identifier: 21910296

GI number: 21910296

Start: 814432

End: 815232

Strand: Direct

Name: folP [H]

Synonym: SpyM3_0760

Alternate gene names: 21910296

Gene position: 814432-815232 (Clockwise)

Preceding gene: 21910295

Following gene: 21910297

Centisome position: 42.85

GC content: 43.95

Gene sequence:

>801_bases
ATGAAAATTGGAAAGTTTGTGATTGAGGGCAATGCGGCTATCATGGGGATTTTAAATGTGACTCCAGATTCTTTTTCAGA
TGGGGGGTCTTACACTACTGTGCAAAAAGCATTAGATCACGTTGAGCAAATGATTGCTGATGGGGCTAAAATCATCGACG
TTGGTGGAGAATCAACACGTCCAGGTTGCCAATTTGTAAGCGCTACCGATGAAATTGACAGGGTGGTTCCTGTGATCAAG
GCCATCAAAGAAAACTATGATATTCTAATCAGCATTGATACCTATAAAACCGAAACAGCTAGAGCAGCTTTAGAGGCGGG
TGCCGATATTCTCAATGATGTTTGGGCAGGTTTGTACGACGGTCAAATGTTTGCCTTAGCAGCCGAGTACGATGCGCCTA
TCATCTTGATGCATAACCAAGACGAAGAAGTTTATCAAGAGGTAACACAAGACGTTTGTGATTTTCTAGGCAATAGAGCA
CAAGCAGCTCTTGATGCTGGCGTGCCAAAAAACAATATTTGGATTGATCCAGGATTTGGATTTGCCAAATCTGTTCAACA
GAATACGGAGTTATTAAAAAGATTGGACCGCGTCTGTCAGTTGGGTTATCCTGTCTTGTTTGGTATTTCGAGAAAGCGTG
TCGTAGATGCCTTGTTAGGTGGCAACACCAAAGCTAAAGAGCGAGACGGAGCGACAGCAGCCTTGTCTGCTTATGCCCTT
GGAAAAGGCTGTCAGATTGTACGCGTACACGATGTCAAGGCTAATCAAGACATTGTGGCTGTGTTGAGCCAGTTGATGTG
A

Upstream 100 bases:

>100_bases
GTAGTAAAACCATTACCACCACTGCCAGAGGCTTATATAAGGAAAGTCGTGCTGAGAGGCAAGAAGTTATTTCTCTAATG
ACAAAAGATTAGGAGAACTT

Downstream 100 bases:

>100_bases
GGACTTATGGATAAAATCGTATTAGAAGGTTGCCGTTTTTATGGCTACCATGGAGCCTTTAAAGAAGAACAGACCCTTGG
GCAAATTTTTCTGGTTGATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWIDPGFGFAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM

Sequences:

>Translated_266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWIDPGFGFAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM
>Mature_266_residues
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIK
AIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRA
QAALDAGVPKNNIWIDPGFGFAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
GKGCQIVRVHDVKANQDIVAVLSQLM

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=256, Percent_Identity=40.625, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=33.6448598130841, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28755; Mature: 28755

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTR
CCCCCEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYD
CCCEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAALDAGVPKNNIWIDPGFG
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCC
FAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GKGCQIVRVHDVKANQDIVAVLSQLM
CCCCEEEEEECCCCCCHHHHHHHHHC
>Mature Secondary Structure
MKIGKFVIEGNAAIMGILNVTPDSFSDGGSYTTVQKALDHVEQMIADGAKIIDVGGESTR
CCCCCEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
PGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAALEAGADILNDVWAGLYD
CCCEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCC
GQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAALDAGVPKNNIWIDPGFG
CEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEECCCCC
FAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGNTKAKERDGATAALSAYAL
HHHHHHHHHHHHHHHHHHHHCCCHHEECCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
GKGCQIVRVHDVKANQDIVAVLSQLM
CCCCEEEEEECCCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]